UGT1A1 is an enzyme involved in metabolizing Irinotecan, a DNA topoisomerase class I inhibitor chemotherapeutic drug. Polymorphisms within the UGT1A1 gene promoter reduce UGT1A1 mRNA express…
Artificial insemination relies on viable semen, the maintenance of which in the swine industry is a challenge due to the gradual decline in sperm quality during chilled storage. Previous stu…
To combat rising mortality due to cancer, it is necessary to develop early diagnostic techniques for the rapid identification of cancer before metastasis. Triple negative breast cancer (TNBC…
This study investigates Potato Virus Y (PVY) in potato crops, a virus that significantly impacts yields for farmers nationwide. PVY is an infectious virus transmitted from plant to plant thr…
Research Ampicillin and amoxicillin are two highly impactful penicillin antibiotics utilized to treat neonatal sepsis and other widespread diseases, improving the health of millions of young…
Several studies have shown that hydroelectric generation systems using an undershot water wheel can reach an efficiency of around 65%; however, making these generation systems out of Fused D…
Gastroparesis, characterized by slowed or absent gastric contractions, affects 1.8% of the population, presents with severe nausea, abdominal pain, a high mortality rate, and incurs high tre…
Arkansas for Medical Sciences A high incidence of hepatorenal impairment in cancer patients treated with cisplatin has been reported. Berberine, a plant alkaloid possesses wide range of medi…
This study examines the effects of trust in the patient -doctor relationship and the physician's empathetic approach on patient satisfaction. It proposes two hypotheses: first, there is a di…
Helmets are designed to protect against severe Traumatic Brain Injury (TBI). TBI can be prevented through impact force dissipation over a larger surface area, cranial deceleration over a len…
As global electricity demand increases, the majority of power is produced by thermoelectric plants using fossil and nuclear fuels, despite the rising role of renewables like solar and wind.…
Zero-knowledge rollups (ZKR), the best scalability solution for the cryptocurrency Ethereum, processes thousands of Ethereum transactions in a batch and uses zk -SNARKs (zero -knowledge succ…
Cancer is the second leading cause of death, behind heart disease, with chemotherapy as one of the primary forms of treatment. As a result, researchers are turning to drug combination therap…
Background: Myocardial ischemia-reperfusion (I/R) injury, a critical cardiac complication, is characterized by an excessive generation of reactive oxygen species (ROS) during heart reoxygena…
Aerodynamic drag and downforce are key factors in automotive design. To decrease drag and increase downforce, novel solutions are created and fluid flow around the vehicles’ bodies is analyz…
One in three people are affected by metabolic disorders including obesity, high cholesterol, and high blood pressure, leading to increased risk of stroke, diabetes, and heart disease. The st…
The deployment of autonomous vehicles (AVs) is rapidly expanding to numerous cities. At the heart of AVs, the object detection module assumes a paramount role, directly influencing all downs…
Arctic sea ice plays integral roles in both polar and global environmental systems, notably ecosystems, communities, and economies. As sea ice continues to decline due to climate change, it…
In patients with Chronic Lymphocytic Leukemia (CLL), there is an overgrowth of leukemic B -lymphocytes. This proliferation of B -cells requires inputs from the external microenvironment, whi…
Can different materials show greater photon propulsion, and what is the acceleration of the best performing material? If solar sailing was more efficient then it could be the new evolution o…
Halo expansions from the early years hide the mysteries of how the universe’s evolution allowed it to reach the point it currently is in. This is because its properties can be tracked from t…
Diabetes is the eighth leading cause of death in the United States, while about 1 in 5 patients are unaware that they have been affected. Being a diabetic, it is required to monitor blood gl…
Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer -related deaths worldwide. Despite therapeutic advances to treat the primary tumor, metastasis cau…
The increasing wildfire frequency and size have posed growing challenges for re -establishing plants after wildfires, making the study of post -wildfire plant regrowth essential for creating…
With an ever-rising plastic waste problem and increasing greenhouse gas emissions, a solution is needed to reduce the environmental impact of plastic while still benefiting from its function…
Heart disease is the leading cause of death in the United States since 1921. As heart failure (HF) is incurable and lethal, developing prediction models is crucial for prevention and early i…
School of Medicine Fusion proteins play a critical role in drug discovery by modeling protein complexes, facilitating protein purification, and allowing researchers to monitor expression. Pr…
Diabetic retinopathy (DR) is the leading cause of blindness among working -age adults. Early detection is crucial to reducing DR -related vision loss risk but is filled with challenges. Manu…
Colon cancer is affluent and greatly impacts the lives of many. Ginger is a common food, yet its health benefits as a whole food and 6-gingerol, as one of its bioactive compounds in preventi…
Glioblastoma (GBM) is the most predominant malignant brain cancer in adults without prognosis improvement in decades (average survival interval of 14 -17 months). Nevertheless, 83% of GBM ca…