ISEF · 2023
Fever Care
Biomedical and Health Sciences
This proposal is made of 4 separate parts, each with their own functions, the first one is “the Headset”, it’s a small squishy box which contains the temperature sensor, and will be tied up…
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38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2023
From Gene to Syndrome: Understanding the Relationship Between Alternative Splicing in Elastin and ASD Development
Biomedical and Health Sciences
Alternative splicing is a process that occurs during gene expression, in which a gene codes for multiple proteins by including or excluding segments (exons) from the mRNA transcript. The spl…
ISEF · 2023
Haloperidol Inhibits Inflammasome Activation via LAMTOR1 and Reduces the Risk of Rheumatoid Arthritis
Translational Medical Science Second Award
Rheumatoid arthritis (RA) is an autoimmune joint disease that affects nearly 1% of people worldwide. RA disproportionately affects women, indigenous peoples, and those of lower socioeconomic…
ISEF · 2023
HDformer: A Higher Dimensional Transformer With a Novel Time Square Attention Mechanism Utilizing Long Range Vascular Signals for Diabetes Detection, and an AI-Based PPG Wearable
Translational Medical Science Second Award
Diabetes mellitus is a global concern, and early detection can prevent serious complications. 50% of people live with undiagnosed diabetes, disproportionately afflicting low-income groups. N…
ISEF · 2023
Higher Serum Testosterone Level Was Associated With Lower Risk of Prediabetes in US Adults: Findings From Nationally Representative Data
Translational Medical Science
Low testosterone may be a novel risk factor for prediabetes. We assessed associations between prediabetes and total serum testosterone (TT), and whether the associations were modified by pop…
ISEF · 2023
Hypothalamic EZH2: A Key Regulator of Leptin Sensitivity in Obesity
Biomedical and Health Sciences Second Award
Obesity is a severe health problem predicted to affect one in two U.S. adults by 2030. Leptin, an adipocyte-derived satiety-inducing peptide hormone, plays a critical role in mediating food…
ISEF · 2023
Identification and Analysis of Metabolic Inhibitors in Ctnnb1-Driven Hepatocellular Carcinoma (HCC)
Translational Medical Science Fourth Award
Liver cancer is the third leading cause of cancer deaths worldwide, resulting in over 800,000 deaths each year. About 90% of all primary liver cancers are characterized as hepatocellular car…
ISEF · 2023
Identification of Biomarkers for Cartilage Damage in Osteoarthritis by RNA-Seq and Proteomic Analysis
Biomedical and Health Sciences
Osteoarthritis (OA) is the most common joint disease, with over 527 million patients worldwide reported in 2019. The diagnosis of OA is mainly based on clinical findings and imaging studies.…
ISEF · 2023
Identification of Cell-Free DNA Methylation Signatures as a Potential Genomic Biomarker of Alzheimer's Disease
Translational Medical Science
Alzheimer’s Disease (AD) is a progressive, neurodegenerative disease that leads to brain atrophy and neuronal apoptosis and is the leading cause of dementia worldwide. Minimal insight has be…
ISEF · 2023
Identification of Environmental Risk Factors Triggering Amyotrophic Lateral Sclerosis in Veterans
Biomedical and Health Sciences
A systematic review of the research literature addressing risk factors for ALS was completed for the years 2011 to 2022. The strongest research articles were then reviewed for the highest po…
ISEF · 2023
Identification of Novel Diagnostic Neuroimaging Biomarkers for Autism Spectrum Disorder Through Convolutional Neural Network-Based Analysis of Functional, Structural, and Diffusion Tensor Imaging Data Towards Enhanced Autism Diagnosis
Translational Medical Science Third Award
Autism Spectrum Disorder is one of the leading neurodevelopmental disorders in our world, present in over 1% of the population and rapidly increasing in prevalence, yet the condition lacks a…
ISEF · 2023
Identifying and Mitigating Renal Toxicity of Lithium on Bipolar Disorder Using HEK293 Cells
Biomedical and Health Sciences Fourth Award
Lithium, the first-line treatment for bipolar disorder (BD), reportedly causes chronic kidney disease (CKD) in at least 20% of patients. To manage BD, physicians prescribe lithium carbonate…
ISEF · 2023
Identifying Novel Drugs to Inhibit APOE4 as a Therapeutic Intervention for Treating Alzheimer's
Translational Medical Science Fourth Award
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impacts memory by destroying the neurons of the brain cells. AD is characterized by the presence of two types of prot…
ISEF · 2023
Identifying Relationships Between the Gut Microbiome and Melanoma Patients' Responses to Immunotherapy Using Machine Learning Techniques
Translational Medical Science
Melanoma is a rapidly metastasizing deadly cancer making it crucial to find the most effective treatment immediately. This year in the US, it is expected to be diagnosed in 97,610 patients a…
ISEF · 2023
Identifying the Molecular Mechanisms of a Safer Neuroblastoma Cure Using the Native Hawaiian 'Awapuhi (Zingiber zerumbet) Herb
Translational Medical Science Fourth Award
Neuroblastoma is one of the most severe tumors in young children with nearly 500 new cases reported each year. Currently, the only treatments available for this cancer are chemotherapy and r…
ISEF · 2023
Immune Checkpoint Regulation in Molecular Subtypes of Endometrial Cancer: Expression of PD-L1 and PD-1
Biomedical and Health Sciences
Endometrial cancer is the 4th commonest cancer in women. The current treatment options show inconsistent results. There is a newer treatment option called targeted therapy. One example uses…
ISEF · 2023
Influences of a Maternal High-Fat Diet (HFD) and Serotonin Transporter (SERT) Deficiencies on Cognitive Flexibility
Biomedical and Health Sciences Third Award
The rising cases of children with autism spectrum disorders (ASD), having restrictive repetitive and impaired social behaviors, can be linked to maternal factors during fetal development. Ad…
ISEF · 2023
Innovative Combination Therapy for Treating Brain Tumors: Using Avatar Models to Help Improve Patient Outcomes
Translational Medical Science
Glioblastoma (GBM), the most malignant brain tumor, remains nearly universally fatal despite aggressive cancer treatment involving surgery, radiation and temozolomide (TMZ) chemotherapy. TMZ…
ISEF · 2023
In silico Accelerated Drug Discovery and Development Utilizing Human Physiological Modeling and Simulation
Biomedical and Health Sciences
The research and development of new medicine are expensive and time-consuming: the entire process from discovery to distribution takes up to 12 years, costing as much as $2.5 billion USD. Hu…
ISEF · 2023
IntelliBind: A Novel Deep-Learning Framework for High-Affinity Antibody Design
Translational Medical Science
The development of therapeutic antibodies with high binding affinities is essential for various in vivo applications, including passive immunization, antigen-presence diagnostics, and cancer…
ISEF · 2023
Investigating Anatomical Connectivity in Individuals With Autism Spectrum Disorder Using Magnetic Resonance Imaging
Biomedical and Health Sciences
Autism spectrum disorder (ASD) is characterized by difficulties in processing sensorimotor information and general cortical excitability. Symptoms are likely attributable to impairments in c…
ISEF · 2023
Investigating Connections Between Sensorimotor Impairment and Resting-State Functional MRI of the Spinal Cord in Multiple Sclerosis
Translational Medical Science
In multiple sclerosis (MS), existing diagnostic tools, including clinical magnetic resonance imaging (MRI) and neurological status scales, do not reliably represent disease severity or progr…
ISEF · 2023
Investigating the Anti-Inflammatory Effects of Famotidine
Biomedical and Health Sciences
Recent research on the drug famotidine suggests it may be an affordable, accessible, safe, and effective treatment against COVID-19. Famotidine is a histamine 2 receptor (H2R) antagonist tha…
ISEF · 2023
Investigating the Effect of Traumatic Brain Injury and THIP on Short-Term Memory in Drosophila melanogaster Using Aversive Phototaxic Suppression
Translational Medical Science
This study aimed to determine whether traumatic brain injury (TBI) causes learning and short-term memory (STM) deficits in Drosophila melanogaster, and if THIP, a GABA-A receptor agonist, wi…
ISEF · 2023
Investigating the Effects of Vinblastine Sulfate Combined With Alpha Tocopheryl Succinate on A549 Lung Cancer Cells and Prostate Cancer Cells
Translational Medical Science
Vinblastine is a cytotoxic drug that has been proven to stunt the growth of cancer cells by binding to the mitotic spindle during anaphase. Studies have shown that Alpha Tocopheryl, a type o…
ISEF · 2023
Investigating the Efficacy of Hyperbaric Oxygen in Modulating IL-6 and EPO in Stem Cell Transplant Patients
Biomedical and Health Sciences
Although stem cell transplants have made promising clinical progress as a treatment for leukemia and other blood cancers, their safety and the severe complications they pose have significant…
ISEF · 2023
Investigating the Impact of Pyruvate Kinase Muscle Isoform 2 (PKM2) Knockout on Cardiac Murine Cellular Hypertrophy
Biomedical and Health Sciences
Myocardial infarction (MI), or heart attack, is the death of cardiac tissue to improper blood and oxygen flow. MI is a form of cardiovascular disease, the current leading cause of death, acc…
ISEF · 2023
Investigating the Potential for Vitamin D3 to Serve as a Therapeutic Against the Degenerative Effects of Diabetes Using Drosophila melanogaster as a Model Organism
Biomedical and Health Sciences Fourth Award
Type two Diabetes is an epidemic. Because there is no cure for diabetes and the current treatments can be expensive and inaccessible, exploration for more affordable management tools for the…
CSEF · 2023
Investigating the proliferation, invasion, and resistance to chemotherapy-induced apoptosis of A549 lung cancer cells in relation to synthetic nicotine exposure
Toxicology Second Award
Marketed as the tobacco-free alternative to traditional rolled cigarettes, e-cigarettes use synthetic nicotine to bypass FDA standards for tobacco products. Synthetic nicotine (TFN), a racem…
ISEF · 2023
Investigating the Role of Rev1 in Maintaining Accurate DNA Replication Past G4 Containing Regions in the Leading and Lagging Strands
Translational Medical Science Fourth Award
G-quadruplex structures (G4s) are one of many secondary structures that genomic DNA adopts, apart from its canonical B-form, and they are a vital part of cellular regulation. Sequences that…