Browse real student projects, abstracts, and awards.
ISEF · 2026
Translational Medical Science
The healing process for severe thermal skin burns is often impeded by inflammation in the wound site and apoptosis, or programmed cell death. Typical treatment for burn wounds revolves aroun…
ISEF · 2026
Biomedical and Health Sciences
Glioblastoma (GBM) is the most common malignant brain cancer in adults, and patient survival still remains low. However, 83% of GBM cases have Telomerase Reverse Transcriptase promoter (TERT…
ISEF · 2026
Biomedical and Health Sciences
Hepatitis B virus (HBV) infects 300 million people worldwide, causing 1.3 million annual deaths. Current treatments can suppress viral replication but fail to eliminate covalently closed cir…
ISEF · 2026
Biomedical and Health Sciences
This project aims to explore the mechanisms the rabies virus uses to evade the immune system while traveling through the nervous system. We are motivated by the challenge of comprehending ho…
ISEF · 2026
Translational Medical Science
Norovirus is the leading cause of gastroenteritis worldwide, causing over 685 million cases each year globally, yet rapid and sensitive detection tools remain limited. All diagnostic technol…
ISEF · 2026
Translational Medical Science
Peritoneal dialysis, one type of dialysis for patients with end-stage renal disease, can be complicated by peritonitis, a life-threatening inflammation of the peritoneum typically caused by…
ISEF · 2026
Biomedical and Health Sciences
Lung cancer is the leading cause of cancer-related deaths and is known to effectively colonize other parts of the body, often evading the immune system as it metastasizes or spreads. Pre-lim…
ISEF · 2026
Biomedical and Health Sciences
Dysregulated astrocytic Ca2+ signaling is a key driver of high-burden CNS disorders, including Alzheimer’s and stroke, yet existing neuromodulation strategies remain invasive and neuron-cent…
ISEF · 2026
Translational Medical Science
Retinal diseases are the major causes of permanent vision loss worldwide, affecting tens of millions of people and making early, accurate detection essential for timely intervention and pres…
ISEF · 2026
Translational Medical Science
GLP-1 drugs address diabetes-obesity crisis that claims 12 lives per minute from associated complications, yet their uncharacterized off-targets may pose long-term health risks. Current safe…
ISEF · 2026
Biomedical and Health Sciences
The skin, the body's largest organ, consists of three layers: the epidermis, dermis, and hypodermis, each with distinct roles. Skin hyperpigmentation disorders, such as Post-inflammatory hyp…
ISEF · 2026
Translational Medical Science
AI-powered breast cancer diagnostics remain inaccessible in low-resource settings due to patient privacy constraints, high hardware costs, and bandwidth limitations. This project designed an…
ISEF · 2026
Biomedical and Health Sciences
Evolution has shaped primates to develop two key advanced traits in comparison with lower mammalian species: first higher intelligence with increased brain size and cortical complexity and s…
ISEF · 2026
Translational Medical Science
Sepsis, responsible for 11,000,000+ deaths globally and 270,000+ annually in the U.S., is very time-sensitive. Mortality increases by 7.6% per hour of delayed antibiotic treatment. Bedside t…
ISEF · 2026
Biomedical and Health Sciences
Breast cancer (BC) is the most expensive cancer to treat in the United States and a leading cause of cancer-related mortality worldwide. Nuclear enlargement is a well-established histopathol…
ISEF · 2026
Translational Medical Science
Purpose: Age-Related Macular Degeneration (AMD) causes a central scotoma that destroys reading ability. Static edge-enhancement aids exist but lack dynamic adaptation. This study developed a…
ISEF · 2026
Translational Medical Science
Malaria is among the earliest documented infectious diseases in humans and remains a major global health challenge. In malaria-endemic regions, anemia substantially worsens outcomes, and sev…
ISEF · 2026
Translational Medical Science
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide, necessitating targeted therapeutic strategies. Curcumin, a natural compound, demonstrates anti-cancer…
ISEF · 2026
Translational Medical Science
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss and limited therapeutic options due to its complex, multifactorial pa…
ISEF · 2026
Translational Medical Science
Endocrine therapy resistance affects ~40% of patients with estrogen receptor-positive (ER+) breast cancer, limiting treatment efficacy and contributing to relapse. The Aryl Hydrocarbon Recep…
ISEF · 2026
Translational Medical Science
Mesenchymal stem cells (MSCs) have differentiation and anti-inflammatory properties, making them effective treatments for diseases including diabetes and osteoarthritis that affect approxima…
ISEF · 2026
Translational Medical Science
Chemotherapy remains the foundation for cancer treatments but is limited by significant side effects resulting from its nonspecific cytotoxicity. In order to counteract this, delivery system…
ISEF · 2026
Biomedical and Health Sciences
Over 200,000 children in the United States live with Juvenile Arthritis (JA), an autoimmune condition that causes chronic inflammation as well as muscle and tissue atrophy. The human GSTT1 (…
ISEF · 2026
Biomedical and Health Sciences
This study aimed to investigate the impact of Phoenix dactylifera (dates) on the progression of Alzheimer’s disease (AD) in Drosophila melanogaster. AD is a prevalent neurodegenerative disor…
ISEF · 2026
Biomedical and Health Sciences
Although hypothyroidism has been extensively studied for its effect on human health, its impact on skeletal development remains insufficiently explored. Thyroid hormones are regulators of bo…
ISEF · 2026
Biomedical and Health Sciences
This study investigated whether red light therapy increases the regeneration rate of planaria. 12 planaria were cut in half and randomly divided into two groups: a red light treatment group…
ISEF · 2026
Biomedical and Health Sciences
Many people think that antioxidants can slow aging and improve overall health, but scientists are not sure that they actually work. In this project, we tested how timing and dose of an antio…
ISEF · 2026
Biomedical and Health Sciences
A goal of this experiment was to add to the limited studies on the connection between E.Coli and colon cancer, specifically, the E. Coli B 2 strain. This experiment used a harmless strain, E…
ISEF · 2026
Translational Medical Science
Neonatal brachial plexus injury (BPI) can lead to significant and lasting motor and sensory impairments, particularly because the brachial plexus is directly connected to the spinal cord. In…
ISEF · 2026
Translational Medical Science
Purpose. Osteosarcoma (OS) is an especially aggressive bone cancer disproportionately affecting children. Current treatments like surgery, chemotherapy, and radiation suffer from high recurr…