Browse 1,236 real Cellular and Molecular Biology projects from CSEF, with abstracts, awards and links to the original entries.
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
CDK4/6 inhibitors are used to treat hormone receptor–positive (HR+), HER2-negative breast cancer by blocking cell-cycle progression. Although several CDK4/6 inhibitors are approved, further…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Resistant hypertension affects billions of people globally, however despite improvements in science and drug discover, hypertension remains one of the most deadly causing over 10 million dea…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Currently, small-molecule drug discovery for diseases such as Alzheimer’s (AD) remains challenging due to the inefficiency and costliness of traditional high-throughput screening (HTS), regu…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Rapid viral evolution continues to outpace conventional vaccine development, particularly for highly variable pathogens such as Influenza A, Norovirus, and HIV. Although epitope-based vaccin…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
This project sought to explore accessible means for extracting horseradish peroxidase (HRP), an enzyme commonly utilized in chemical and biological experiments. While purified HRP can be eas…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Interactomes provide a framework for mapping the cellular interactions that drive essential biological processes, revealing how their disruption leads to diseases like cancer. Analysis of su…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
By 2050, food production must rise to meet the needs of a global population of over nine billion people. However, plant-parasitic nematodes (PPNs) are a leading cause of annual agricultural…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Title: Blue in Orange Juice This project studied how quickly vitamin C degrades when oranges are stored in a freezer, refrigerator, or at room temperature. It was hypothesized that freezing…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
The vast number of mutations within a genome makes it a central challenge in genomics to determine the process behind how mutations result in phenotypic diversity. Humans have bred dogs over…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Acute Lymphoblastic Leukemia is the most common childhood cancer and has over 300,000 cases globablly, rapidly progressing in the blood and bone marrow. ALL affected cells often overexpress…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Medulloblastoma is a fast-growing brain tumor that mostly affects children. Current treatments like chemotherapy and radiation can hurt healthy cells and cause bad side effects, sometime lea…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Depression is a serious mental health disorder that affects individuals of all ages, including high school students. Social stress and ongoing emotional development contribute to a growing r…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Reliable characterization of cell states, which encompass a cell’s function, environment, and structure, is fundamental to comprehending healthy cell function and molecular pathways driving…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Many melanoma patients who initially respond to targeted BRAF-inhibitor therapies develop drug resistance that is often fatal. While current research has identified phenotype switching in ma…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Telomerase is a ribonucleoprotein reverse transcriptase that preserves chromosomal integrity by extending telomeres, yet it is upregulated in over 85% of cancers, enabling indefinite replica…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Biosensors are an innovative technology that use fluorescence to visualize protein expression and activity in eukaryotic cells primarily using a Forster Resonance Energy Transfer (FRET) syst…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Oxidative stress is linked to many human diseases, including aging, cancer, heart disease, and neurodegenerative disorders such as Alzheimer's disease. It occurs when too many reactive oxyge…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Diabetes is characterized by dysregulated glucose homeostasis due to reduced quantity and quality of functional insulin-producing beta-cells in the pancreas. Accumulation of DNA damage in pa…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
To combat cancer and address drug resistance, there is growing scientific interest in plants that produce compounds with therapeutic potential. CAM (Crassulacean Acid Metabolism) plant Kalan…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Vitamin C is a crucial variable needed in the human body in order for it to fruition accordingly. However, when food is cooked, the concentration level of vitamin C can be significantly decr…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Cervical cancer is the 2nd largest among all gynecological cancer cases reported worldwide and is a challenge to treat. Immunotherapy remains a widely recognized treatment option but suffers…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
This experiment tested yeast fermentation efficiency across four types of sugar: granulated sugar, brown sugar, corn syrup, and honey. To conduct the test, 10g of each sugar was dissolved in…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Protein glycosylation is a highly diverse and complex post-translational modification that is critical to many biological processes, such as intercellular communication and protein folding.…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Gelatin forms a strong three dimensional network during gelation, where protein chains trap water within a branching framework. This project investigates the biochemical effects of citric ac…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Medulloblastoma, the most common malignant pediatric brain tumor, is driven in ~30% of cases by aberrant Hedgehog signaling through GLI transcription factors. FDA-approved upstream inhibitor…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
This study examines the effect of Beta Vulgaris, or beetroot, a plant rich in antioxidants, on the stress resistance in mutations in the FOXO3 gene pathway. Using the model organism C. elega…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Yogurt is made using a process called milk fermentation. During fermentation, bacteria break down lactose and turn it into lactic acid. This buildup of acid lowers the pH which results in th…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
https://docs.google.com/document/d/1tn5tmgzB23CuLVm_JdctPO9ImQ3IXkAhN6UfprGVsMQ/edit?usp=drivesdk
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Hormone-driven cancers, such as prostate cancer, rely on hormone receptor signaling for growth and survival. While hormone deprivation therapies are initially effective, prolonged treatment…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Methylmercury, a bioaccumulative toxin linked to neurological damage, enters cells by mimicking essential nutrients. Its L-cysteine conjugate structurally resembles L-methionine, hijacking l…