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AI-Integrated Multi-scale Modeling of Baroreceptor Restoration

CSEF · 2026 Biochemistry/ Molecular Biology (Senior Division)

Aman Nalem

Overview

Resistant hypertension affects billions of people globally, however despite improvements in science and drug discover, hypertension remains one of the most deadly causing over 10 million deaths yearly. My project aims double blood pressure control by aiming to reactivate baroreceptors. Baroreceptors are sensors in our bloodstream that stretch depending on the amount of blood passing through the blood vessels. The baroreceptors then send signals to the brain, which then tells the heart to pump faster or slower. My research involves creating a compound to activate the PIEZO1 and PIEZO2 proteins in baroreceptors. These proteins are the main protein that turns these fluctuation readings into ions which the brain then can read. However as humans age, these proteins become less effective. So my goal is to create a targeted therapy to activate the two proteins potentially lowering hypertension or hypotension cases. I have created 175 compounds using scaffolds and discovered a novel compound Comp_52789 that reaches a binding free energy of -9.84 ± 0.42 kcal/mol.

Competition history

  • CSEF 2026 Biochemistry/ Molecular Biology (Senior Division) · Entry S-04-03

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