fairfolio
Saved Projects

Exosome-Packed Phenyl Boronate, a Redox Scavenger as an Effective Sensitizer for Immunotherapy in Cervical Cancer

CSEF · 2026 Biochemistry/ Molecular Biology (Senior Division)

Annika Chatterjee

Overview

Cervical cancer is the 2nd largest among all gynecological cancer cases reported worldwide and is a challenge to treat. Immunotherapy remains a widely recognized treatment option but suffers from challenges such as T cell exhaustion. Redox intermediates released by tumor cells were reported to limit the effectiveness of T cell therapy. Based on the above, I devised a bioengineering strategy to construct a T cell prototype involving packing of a peroxynitrite inhibitor in endogenous exosome vehicles and loading them into CD8+ve T cells. My results showed that the PBA-packed exosome construct inserted into CD8+ve T cells decreased peroxynitrite release from cancer cells and induced apoptosis as determined by staining if Annexin-V and Propidium Iodide, thus leading to effective cancer cell killing. My results have far-reaching implications in cancer immunotherapy as they provide a new paradigm to overcome the limitations of immunotherapy that involve T cells.

Competition history

  • CSEF 2026 Biochemistry/ Molecular Biology (Senior Division) · Entry S-04-04

Related projects

Closest projects by meaning, across every fair and year in the corpus.

Browse more like this

Source: California Science & Engineering Fair public projects

Save projects to your library

Sign in with Google to keep track of projects you find interesting, organized into folders. An account also raises your daily allowance for “Has this been done?”, and lets you create a key for the MCP server with a much higher limit than anonymous use. Browsing stays public.

Continue with Google