Search past science fair projects

Designing Peptide Inhibitors to Prevent Amyloid Beta Aggregation

Computational Biology and Bioinformatics

In Alzheimer’s disease, a progressive neurodegenerative disease, a key pathological feature of the is the accumulation of amyloid-ß peptides in the brain, which aggregate to form plaques tha…

Designing Safer Microbial Plastic Degraders: CasTune — An Optimized dCas13d-IF3 Framework for Higher PETase Production in E. coli

Computational Biology and Bioinformatics

Global PET levels contribute significantly to the world's plastic pollution. A promising biotechnological solution that minimizes harmful byproduct release is utilizing enzymatic degradation…

Design of a Multi-Mechanistic Triple Therapy to Overcome Biofilm-Associated Resistance in Pseudomonas aeruginosa

Microbiology

Biofilm-mediated resistance is a major barrier to treating Pseudomonas aeruginosa infections. Biofilms are estimated to contribute to over 65% of microbial infections, allowing bacteria to p…

Design of a Novel Dual-Functional Photocatalyst Based on Metal Oxides and Carbon Dot–Modified MOF-5 for CO2 Capture and Conversion

Chemistry

The limitations of traditional CO2 capture technologies and the rapid rise in CO2 emissions necessitate efficient methods and materials for CO2 capture and conversion under mild conditions.…

Design of a Novel, Dual-Functioning, T-Cell-Engaging and Cytarabine-Based Nanotherapeutic for Acute Myeloid Leukemia Treatment

Biomedical and Health Sciences

Leukemia remains a leading cause of global cancer mortality, with Acute Myeloid Leukemia (AML) presenting the most aggressive clinical profile with frequent relapse even after treatment. Ove…

Design, Synthesis, and Testing of a Novel 3,5-Dimethoxycinnamic Acid-based Cathepsin C Inhibitor for the Treatment of Inflammatory Bowel Disease

Translational Medical Science

Inflammatory bowel disease (IBD), which encompasses Crohn's disease and ulcerative colitis, affects about 5 million people worldwide and is caused by the inflammation of the gastrointestinal…

Design Synthesis, Dynamic Modeling, and Machine Learning–Enhanced Control of a Dual-Axis Thrust Vectoring Gimbal for Active Stabilization in Small-Scale Rocket Systems

Engineering Technology: Statics & Dynamics

Thrust vector control (TVC) enables rockets to adjust their trajectory by redirecting engine thrust, providing active stabilization during powered flight when aerodynamic fins are less effec…

CYSF · 2026

Dessert time! What is the cost of having cookies for dessert?

We are tracking the cost of a package cookies at multiple stores over a 20-week period to observe any pricing trends within and between stores.

Detecting Causality in (2+1)-Dimensional Globally Hyperbolic Spacetimes Using Conjugation Quandles Over Dihedral Groups

Mathematics

I investigated whether quandle colorings (homomorphisms) can detect causality for links realized as skies in a (2+1)-dimensional globally hyperbolic spacetime X. I built on the Allen–Swenber…

Detecting Damage in Strings Using Acoustic Inharmonicity and Damping Coefficients

Technology Enhances the Arts

Damage to musical strings can degrade sound quality or even cause sudden failure during a musical performance. For large wire-cables, complex methods measuring the propagation of vibrations…

Detecting Outliers in 3D Point Clouds Using Higher-Order Geometric Cycles for Accurate 3D Reconstruction

Robotics and Intelligent Machines

3D point clouds are fundamental to robot perception and 3D reconstruction. However, due to interference, they often contain outliers which distort surface geometry and degrade the performanc…

Detecting Perfluoroalkyl Chemicals in Heuchera Utilizing Infrared Spectroscopy

Chemistry

PFAS chemicals, or perfluorinated substances, are commonly found in household products, like non-stick cookware, waterproof materials, and fabrics. PFAS, or perfluorinated substances, are co…

Detection of Trifluoroacetic Acid in Commercial Water Filters and Its Toxicological Impacts on Keystone Aquatic Species

Earth and Environmental Sciences

Polyfluoroalkyl substances are present in 45% of U.S. drinking water, threatening human and environmental health due to their high polarity and persistence. Trifluoroacetic acids (TFAs), a t…

Determining If Phenethyl Isothiocyanate (PEITC) Is an Effective Tumor Suppressant in Yki-S168A Drosophila melanogaster Mutants

Animal Sciences

Cruciferous vegetables, commonly consumed vegetables, contain a cancer fighting compound, phenethyl isothiocyanate (PEITC). PEITC has been found to inhibit cell proliferation and induce apop…

Determining the Concentration of Sugar Within a Liquid Using the Refraction of Light

Physics and Astronomy

When light travels from one medium into another, it bends. This phenomenon is called light refraction. The angle at which the light bends is determined by the density of the medium it travel…

Determining the in vitro Post-Antimicrobial Effect in Staphylococcus epidermidis With Piperine Incorporation

Microbiology

Staphylococcus epidermidis is a leading cause of infections associated with indwelling medical devices and accounts for over 20% of bloodstream infections in U.S. intensive care units. Altho…

Determining the Potential Toxicity of Fracking Surfactants: An Assessment of Product Viability to Reduce Environmental Water Contamination

Earth and Environmental Sciences

Fracking is the process of extraction through injection of liquids containing chemicals at high pressures to force open pre-existing fissures. Surfactants provide a protective layer for the…

Developing a CNP-Based Therapy to Strengthen Dysregulated Connective Tissue Signaling in Hypermobile Ehlers-Danlos Syndrome

Biochemistry

Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by collagen disorganization and impaired extracellular matrix signaling (ECM), resulting in chronic jo…

Developing a Colorimetric Patch and Toxicity Index for Detecting Components in Secondhand Smoke

Environmental Engineering

Secondhand smoke (SHS) is a major public health concern, causing over 1.3 million deaths globally each year. Despite its links to cancer and respiratory disease, SHS is difficult to detect i…

Developing a Human-Computer Interface to Assist Patients With Parkinson’s Disease to Improve Motor Function

Biomedical Engineering

Parkinson’s disease is a common progressive neurodegenerative disorder that is known to affect movement and coordination. It causes debilitating motor symptoms, including tremor, bradykinesi…

Developing a Method to Evaluate Skin Aging Using Proteomics Technology

Translational Medical Science

Background: Skin aging is a natural biological process that was cause by a comprehensive combination of intrinsic and extrinsic factors. This process varies a lot among individuals and often…

Developing an Enhancement Tool for Arabic Speaking Children at Risk of Dyslexia

Behavioral and Social Sciences

Dyslexia is a neurodevelopmental disorder that primarily affects reading abilities. Early identification of dyslexia is crucial because early intervention can improve reading skills. However…

Developing an Open Source WLAN Driver and Stack for the ESP32

Embedded Systems

WLAN is used by pretty much everyone, and often carries sensitive data. However, the hardware is pretty much always very locked down and limited. This means, that it can't be audited for sec…

Developing a Novel Adaptive Tuning Module for Real-Time Frequency Correction in Radiofrequency Coils During Concurrent TMS-fMRI

Embedded Systems

Concurrent transcranial magnetic stimulation-functional magnetic resonance imaging (TMS-fMRI) is a promising neuroimaging approach to visualize brain activity during TMS, improving targeting…

Developing a Novel Superhydrophobic GO–Ni/PAN Membrane for Interfacial Solar Steam Generation

Environmental Engineering

Interfacial solar steam generation systems offer a promising solution to freshwater scarcity and energy-intensive desalination. However, most current research uses hydrophilic membranes that…

Developing a Novel Sustainable Bio-Adsorbent Derived From Agricultural Biomass and Iron-Functionalized Biochar for the Removal of Algal Toxin From Water

Earth and Environmental Sciences

Harmful algal blooms caused by cyanobacteria have become a growing global concern due to their release of potent toxins, one of which includes microcystin (MC-LR). This toxin threatens drink…

Developing a Platinum Fractal Microneedle Biosensor for Uric Acid Monitoring

Biomedical Engineering

Chronic kidney disease (CKD) is a major global health problem affecting over 850 million people, with direct costs exceeding 372 billion USD annually. Uric acid is an important renal biomark…

Developing a Rapid Screening Approach for Milk Counterfeiting Risks Using Infrared Spectroscopy Combined With Chemometrics

Chemistry

Counterfeit milk accounts for up to 14% of food fraud cases globally, severely impacting the economic, consumers health, and manufacturers reputation, particularly in solid-state milk produc…

Developing a Real-Time Forecasting Model and Evaluating the Potential for Improving Pollution Levels in the Cau Bay River, Hanoi

Chemistry

Introduction: The Cau Bay River is an important drainage waterway for the Long Bien-Gia Lam area (Hanoi). Effective water quality monitoring and real-time predictive modeling are critical fo…

Developing Sustainable Glycerol-Based Monomers for Polymer Blends Using 3D Printing

Materials Science

Glycerol has become an ideal candidate for bio-polymer synthesis with the growth of the biodiesel industry. Glycerol’s molecular structure allows for easy modification with functional groups…