Browse real student projects, abstracts, and awards.
ISEF · 2025
Microbiology
Staphylococcus aureus is a gram-positive pathogenic bacteria that causes community-onset and nosocomial infections, making it a global healthcare threat. Its ability to evade host responses…
ISEF · 2025
Mathematics
This study delves into the computation and classification of combinatorial invariants associated with stable curves in genus 4. The work builds upon Zhang's decomposition formula, emphasizin…
ISEF · 2025
Translational Medical Science
Oral cancer kills over 300,000 lives across the world every year, and oral squamous cell carcinoma (OSCC) is a dominant type of oral cancer. Current diagnosis steps for OSCC typically involv…
ISEF · 2025
Plant Sciences
The parasitic plant, Striga hermonthica, threatens food security in Africa and affects the income of smallholder farmers, with impacts between $7-10 billion USD annually. A newly emerging st…
ISEF · 2025
Biomedical and Health Sciences
Chimeric Antigen Receptor (CAR) T Cells and Bispecific T Cell Engagers (BiTEs) have revolutionized the treatment of relapsed/refractory hematologic cancers. However, there are no head-to-hea…
ISEF · 2025
Energy: Sustainable Materials and Design
First-generation biofuel crops, like corn and peanuts, are effective for biodiesel production, but compete with food crops and require arable land use. Third-generation biofuels, such as bee…
ISEF · 2025
Translational Medical Science
Psoriasis is a chronic immune-mediated inflammatory disorder affecting over 125 million individuals worldwide, characterized by keratinocyte hyperproliferation and dysregulated inflammatory…
ISEF · 2025
Chemistry
Antibiotic-resistant bacteria cause over 2 million infections annually in the US, driving the need for new antimicrobials. Zinc oxide nanoparticles (ZnONPs) are a promising solution, but con…
ISEF · 2025
Plant Sciences
Sallyqueen is a rice variety derived from a Nipponbare × BASMATI370 cross. Its grain length and width are approximately 1.15 and 0.73 times that of Nipponbare, respectively. Some grains were…
ISEF · 2025
Energy: Sustainable Materials and Design
This science fair project is about Peltier Tiles and Piezoelectric Harvesters and determining which renewable energy source serves as a better source of electricity and applications for both…
ISEF · 2025
Robotics and Intelligent Machines
The citrus industry in Florida has been devastated with multiple diseases - greening, canker, and blackspot - leading to tree death, orchard closure, and lost orange production. Traditional…
ISEF · 2025
Microbiology
Tardigrades are one of the many organisms that have the capability of surviving extreme environments. They do this by going into a stasis known as cryptobiosis including the lack of water kn…
ISEF · 2025
Earth and Environmental Sciences
This project investigated the correlation between solar indices (AE, By, Bz, SYM_H, and F10.7), aurora activity, and TIMt layers. This research was motivated by the findings of Chu et al. 20…
ISEF · 2025
Computational Biology and Bioinformatics
Competitive target-mediated drug disposition (competitive TMDD) has been used to describe the behavior of two different types of ligands competing for a common receptor. Due to the complexit…
ISEF · 2025
Engineering Technology: Statics & Dynamics
At the moment, there are over 60,000 km² of mined areas around the world and approximately 110 million landmines remaining, while their manual removal is not feasible at the current rate of…
ISEF · 2025
Energy: Sustainable Materials and Design
In this project our goal was to create a machine capable of heating water with compost. The machine uses a process called hot composting. This occurs when a compost pile is made with the cor…
ISEF · 2025
Environmental Engineering
Food wastes are a major environmental pollutant due to the greenhouse gases that are emitted by them, like: methane. It should be notice that Food loss and waste is estimated to be roughly o…
ISEF · 2025
Microbiology
Plant-based natural products are utilized as active ingredients in herbal medicines, and studying their bioactivities is necessary for evaluating their medicinal value. The present study aim…
ISEF · 2025
Translational Medical Science
Malaria is a devastating disease that kills over half a million people annually. Research shows the Plasmodium falciparum protozoan disrupts iron regulation by degrading ferroportin, allowin…
ISEF · 2025
Earth and Environmental Sciences
Surface water is decreasing in the Rio Grande as a consequence of climate change, intensifying the vulnerability of our aquifers due to higher demand for groundwater pumping. Agricultural pr…
ISEF · 2025
Computational Biology and Bioinformatics
This study aimed to identify potential inhibitors of meso-diaminopimelate decarboxylase (LYASE), a bacterial enzyme crucial for lysine biosynthesis, using molecular docking simulations. The…
ISEF · 2025
Microbiology
Antibiotic resistance is a major global health threat projected by the World Health Organization to cause 10 million deaths annually by 2050. Autolysins like AtlA, essential for bacterial ce…
ISEF · 2025
Computational Biology and Bioinformatics
Every year, approximately 90,000 people in the United States are diagnosed with lymphoma, a cancer impacting white blood cells called lymphocytes. The CD30 receptor, overexpressed in Hodgkin…
ISEF · 2025
Computational Biology and Bioinformatics
Cannabinoid receptor subtype 2 (CB2), a G protein-coupled receptor within the endocannabinoid system (ECS), has shown promise as a therapeutic target in cancer and inflammatory diseases due…
ISEF · 2025
Systems Software
Sabre fencing is a sport of split-second decisions, where in 60% of points, both fencers land touches within milliseconds of each other. In such cases, determining who earns the point is ent…
ISEF · 2025
Physics and Astronomy
A planet is an object that moves through space in a fixed path, orbiting a star or remnants of a star. An exoplanet is a planet outside our solar system. The TESS space telescope has identif…
ISEF · 2025
Physics and Astronomy
Neutron stars are remnants of the cores of massive stars after they undergo supernovae at the end of their lives. They were theoretically predicted in the 1930s and first observed in the 196…
ISEF · 2025
Earth and Environmental Sciences
This experiment was performed to significantly cut down the amount of polluted freshwater bodies in the world. This experiment has findings that make this much faster, easier, and cheaper th…
ISEF · 2025
Biomedical Engineering
Pneumonia, an infection of the lungs where air sacs fill with fluid, causes 2.5 million annual deaths and is the leading cause of death in children under five. From scratch, we developed a c…
ISEF · 2025
Translational Medical Science
This project presents the development of three AI-powered diagnostic tools capable of identifying malaria, leukemia, and anemia from peripheral blood smear (PBS) images using convolutional n…