Browse real student projects, abstracts, and awards.
ISEF · 2026
Chemistry
Aromatic amino acids phenylalanine (Phe), tryptophan (Trp), and tyrosine (Tyr) show increased plasma concentrations in cases of phenylketonuria, tryptophanemia, and tyrosinemia type I that o…
ISEF · 2026
Embedded Systems
Modern semiconductors are typically closed-source and lack transparency in design and production. The resulting inability to verify chips allows the introduction of undetectable hardware bac…
ISEF · 2026
Computational Biology and Bioinformatics
The incurable nature of Amyotrophic Lateral Sclerosis (ALS) is compounded by a diagnostic lag, where symptoms emerge only after irreversible motor neuron attrition. Rather than viewing ALS s…
ISEF · 2026
Biochemistry
Around the world, 15% of adolescents struggle with mental illnesses affecting mood and behavior. Depression, one of the most common conditions, is diagnosed primarily through clinical evalua…
ISEF · 2026
Computational Biology and Bioinformatics
G protein-coupled receptors (GPCRs) are one of the most therapeutically important receptor families, being the target of >30% of FDA-approved drugs. Activating a GPCR changes its shape, allo…
ISEF · 2026
Robotics and Intelligent Machines
Global waste is increasing every year, and despite awareness campaigns, recycling rates remain low. Current systems rely heavily on human participation, which is often inconsistent and error…
ISEF · 2026
Behavioral and Social Sciences
Pedestrian-vehicle conflict at intersections is a major safety challenge, as conventional fixed-time traffic signals do not adapt to real-time pedestrian crossing behavior and drivers often…
ISEF · 2026
Engineering Technology: Statics & Dynamics
Outdoor pets face risks from sudden flooding and extreme heat when owners are away. This project addresses engineering problem of designing an off-grid shelter that monitors and maintains a…
ISEF · 2026
Environmental Engineering
Non-Polar Organic Contaminants (NPOCs) such as Micro/Nano-sized Microplastics (MNMPs), oils and Benzene, Toluene, Ethyl Benzene, Xylene (BTEX) are emerging contaminants that are critical thr…
ISEF · 2026
Biomedical Engineering
Peripheral neuropathy is a progressive condition that reduces sensation in the feet, leading to impaired balance, altered plantar pressure distribution, and increased risk of falls or injuri…
ISEF · 2026
Translational Medical Science
Purpose: Age-Related Macular Degeneration (AMD) causes a central scotoma that destroys reading ability. Static edge-enhancement aids exist but lack dynamic adaptation. This study developed a…
ISEF · 2026
Cellular and Molecular Biology
Modern nucleic acid sequencing enables rapid and cost-effective genomic analysis, but for low-input samples, amplification via polymerase chain reaction (PCR) remains a critical bottleneck.…
ISEF · 2026
Chemistry
Current organic photovoltaics (OPV) have narrow light absorbance, inefficient electron transport, and low energy output. This project aims to solve these efficiency issues by designing an or…
ISEF · 2026
Energy: Sustainable Materials and Design
In arid climates, they face extreme temperatures, water scarcity, and high energy demands for irrigation. At the same time, the aluminum industry generates carbon-rich waste, creating enviro…
ISEF · 2026
Mathematics
An equation f(x)=a, where f is a complex meromorphic function and a is a parameter, is solvable in elementary functions if the inverse map x=f^{-1}(a) can be expressed as a finite compositio…
ISEF · 2026
Biomedical Engineering
Ultrasound(US)-guided vascular access requires a high level of expertise as the clinician must understand the spatial relationship between US probe, imaging, and the patient’s anatomy. Furth…
ISEF · 2026
Environmental Engineering
Every year, approximately 400 million tons of plastic are produced worldwide, yet only 9% is recycled. Meanwhile, heavy metal contamination of water poses significant risks to human health,…
ISEF · 2026
Animal Sciences
Numerous factors can affect avian biodiversity including air temperature, precipitation, wind, and air quality. This study aimed to determine how these meteorological and wildfire-related fa…
ISEF · 2026
Cellular and Molecular Biology
Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the United States, with metastasis responsible for the majority of CRC deaths. Emerging research suggests that micro…
ISEF · 2026
Computational Biology and Bioinformatics
Lung cancer remains the leading cause of cancer-related mortality, primarily due to its high metastatic potential and difficulty of early detection. Current clinical approaches rely on low-s…
ISEF · 2026
Translational Medical Science
Malaria is among the earliest documented infectious diseases in humans and remains a major global health challenge. In malaria-endemic regions, anemia substantially worsens outcomes, and sev…
ISEF · 2026
Computational Biology and Bioinformatics
Whole-slide histopathology images(WSIs) form the backbone of AI development in cancer research. However, their high curation cost, gigapixel complexity, and limited availability across insti…
ISEF · 2026
Software Design
Instantly forecasting a table tennis ball’s trajectory—including spin and landing spot—before it crosses the net while matching elite athlete performance, is a key challenge in spatial intel…
ISEF · 2026
Software Design
Nonverbal autistic individuals depend on Augmentative and Alternative Communication (AAC) systems, yet existing tools limit expressive flexibility and require time-consuming card navigation.…
ISEF · 2026
Physics and Astronomy
Determining stellar ages at the scale of modern spectroscopic surveys is hindered by the extreme computational cost of professional Bayesian isochrone-fitting pipelines, which limits large-s…
ISEF · 2026
Chemistry
In recent years, functional nanostructured materials with high catalytic stability, low cost, and tunable catalytic properties have become excellent alternatives to natural enzymes used as b…
ISEF · 2026
Chemistry
Spent coffee ground (SCG) is a globally available powder form waste derived from coffee extraction with a production of 42,000 tons daily. 700,000 tons of synthetic dyes are produced annuall…
ISEF · 2026
Physics and Astronomy
Gate-all-around (GAA) transistors are central to the development of next-generation 2 nm-node semiconductor technologies, but their operation is strongly governed by quantum confinement, req…
ISEF · 2026
Materials Science
Foodborne illness affects approximately 10% of the global population each year, highlighting the need for accessible, real-time tools for monitoring food spoilage at the consumer level. Amon…
ISEF · 2026
Biomedical Engineering
Background: Parkinson's Disease significantly impairs quality of life through motor deficits like tremors. Current pharmacological treatments often carry side effects, while physical therapy…