Browse real student projects, abstracts, and awards.
ISEF · 2026
Translational Medical Science
Triple-negative breast cancer (TNBC) is one of the deadliest breast cancer subtypes because it lacks the receptors targeted by most therapies, leaving patients with few treatment options. Th…
ISEF · 2026
Software Design
Photodynamic Therapy (PDT) is a non-invasive treatment for esophageal, skin, and non-small-cell lung cancers that relies on light-activated drugs called photosensitizers to generate cytotoxi…
ISEF · 2026
Earth and Environmental Sciences
According to UNEP, Sand is the most mined solid natural resource in the world, with up to 50 billion tons used annually. This high demand results in unmonitored illegal mining. It is a $350…
ISEF · 2026
Software Design
MANTIS is the first entirely computerized muon-based subsurface imaging system. Its goal is to deliver a fully non-invasive and remote method for underground imaging that eliminates the need…
ISEF · 2026
Materials Science
Moon colonization would benefit from manufacturing using local materials such as moon dust, a basaltic volcanic ash (BVA). We investigate the feasibility of additive 3D printing (FDM) with a…
ISEF · 2026
Microbiology
Manuka honey is known for its antimicrobial properties, but it is unclear how heating affects its ability to inhibit bacterial growth. This experiment tested whether increasing the temperatu…
ISEF · 2026
Behavioral and Social Sciences
This study examined the lack of access to Brazil’s Unified Health System (SUS) for People with Disabilities (PWDs) in Sao Paulo’s Paraisopolis favela. It aimed to map and characterize PWD re…
ISEF · 2026
Mathematics
This project investigates how player market value in professional soccer is shaped by long-term ability and short-term seasonal performance. Transfer markets often show inconsistencies betwe…
ISEF · 2026
Robotics and Intelligent Machines
Kenyan Sign Language (KSL) remains absent from AI research despite serving 600,000 Deaf Kenyans. Existing recognition systems, including those for ASL and BSL, fail under real-world conditio…
ISEF · 2026
Computational Biology and Bioinformatics
Glioblastoma (GBM) is the most aggressive type of primary brain tumor, with limited response to standard temozolomide (TMZ) therapy due to resistance. Thus, the search for alternative treatm…
ISEF · 2026
Robotics and Intelligent Machines
In fields such as exploration or inspection in hazardous environments, the ability to navigate terrain safely is crucial. This is often done through robotics; however, traditional systems (r…
ISEF · 2026
Translational Medical Science
Diagnosing drug-resistant strains Mycobacterium tuberculosis (Mtb) is critical for informing treatment plans and limiting infections. However, existing diagnostics are slow and cover a narro…
ISEF · 2026
Physics and Astronomy
Purpose: Entanglement determines how quantum information is stored and processed, but measurements impact entanglement behavior in open quantum circuits. This project studies entanglement ph…
ISEF · 2026
Materials Science
Artificial turf systems are essential for modern sports infrastructure; however, their long-term safety and playability are often compromised by the mechanical qualities of traditional polym…
ISEF · 2026
Materials Science
This study investigates the effects of environmental temperature fluctuations and ultrasonic cleaning on the mechanical properties of two polymers: polyethylene terephthalate glycol (PETG) a…
ISEF · 2026
Animal Sciences
Although fish skin is widely recognized as an important physical and chemical barrier against infection, the specific defensive mechanisms mediated by skin mucus have been insufficiently cat…
ISEF · 2026
Computational Biology and Bioinformatics
Spinal Cord Injuries (SCI) generally cause permanent functional loss due to the accumulation of inhibitory molecules, such as chondroitin sulfate proteoglycans (CSPGs), synthesized by a mult…
ISEF · 2026
Biomedical and Health Sciences
Chemoresistance remains a primary cause of cancer treatment failure and is increasingly attributed to non-genetic regulatory mechanisms. Emerging evidence suggests that three-dimensional chr…
ISEF · 2026
Earth and Environmental Sciences
Nitrobenzene is a potential carcinogen, highly flammable, and toxic environmental pollutant in air, water, and soil that is commonly synthesized in pesticide, dye, and explosives manufacturi…
ISEF · 2026
Biomedical Engineering
As humanity ventures beyond Earth, the challenges of space travel extend beyond rocket science and astrophysics. Astronauts face extreme physiological stress, and during deep-space missions…
ISEF · 2026
Robotics and Intelligent Machines
Large language models (LLMs) are increasingly trusted in domains such as education, research, and decision making. Despite their widespread adoption, fundamental questions remain about align…
ISEF · 2026
Chemistry
This study was aimed at examining the effects of metal ions on the classical ninhydrin reaction. During the process, a surface-bound species was incidentally discovered, and its structure an…
ISEF · 2026
Earth and Environmental Sciences
This experiment focuses on the effectiveness of metal oxide nanoparticle infused biochar in adsorbing heavy metals (Pb and Cd) from simulated runoff. The basis of this experiment is the surf…
ISEF · 2026
Robotics and Intelligent Machines
A significant number of bridges in the United States are susceptible to failure, and one of the main factors that causes failure is overload. Severe consequences can result from bridge failu…
ISEF · 2026
Earth and Environmental Sciences
Methane (CH4) emissions from flooded rice paddies are a major contributor to agricultural greenhouse gases, driven by the anaerobic activity of methanogenic archaea in soil environments. Red…
ISEF · 2026
Cellular and Molecular Biology
Background Hair loss resulting from follicular miniaturization and stem-cell exhaustion lacks effective biological reversal strategies. Traditional hair restoration relies on follicular tran…
ISEF · 2026
Biomedical Engineering
MicroMCED is designed to bring routine multicancer screenings to more people with an accessible point of care blood test. Current screening tests require expensive specialized equipment that…
ISEF · 2026
Earth and Environmental Sciences
This study investigated Martian soil and different way to enhance the soil for plants to grow on Mars because the soil on this planet is not able to support life let alone grow food. I teste…
ISEF · 2026
Plant Sciences
Plant callus cells are undifferentiated, disorganized, proliferating cells that can form on plant tissues in response to wounding in vivo or phytohormone-induced stimuli in vitro, and are us…
ISEF · 2026
Behavioral and Social Sciences
The rise in cases of depression, anxiety, and other emotional disorders has led to an alarming increase in deaths from self-inflicted causes, especially among adults under work, academic, an…