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Method of Autologous Primary Hair Follicles Preparation in 3D Culture

ISEF · 2026 Cellular and Molecular Biology

Namjoshi, Zara · Ecole Mondiale World School

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Overview

Background Hair loss resulting from follicular miniaturization and stem-cell exhaustion lacks effective biological reversal strategies. Traditional hair restoration relies on follicular transplantation rather than regeneration. This patented system recreates embryonic folliculogenesis by co-culturing dermal papilla cells and epithelial stem cells in a 3D fibrin-based extracellular-matrix scaffold enriched with growth-factor complexes (FGF-7, IGF-1, VEGF, HGF). The protocol promotes mesenchyme-epithelium signaling, mimicking developmental niche behavior to induce follicle neogenesis. Laboratory evaluation demonstrated formation of follicular germ-like structures, early folliculoid aggregates, and enhanced expression of hair-inductive markers. Preliminary clinical-grade data suggest improvement in hair-density parameters following autologous cell implantation. This autologous regenerative platform demonstrates a feasible translational approach to biological hair restoration without transplantation.

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Awards (1)

  • Zydus Pharmaceuticals USA Inc.: First Place Cellular and Molecular Biology

Competition history

  • ISEF 2026 Cellular and Molecular Biology · Entry CELL045 Affiliated fair in DELHI, India

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Source: Regeneron International Science and Engineering Fair

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