Browse real student projects, abstracts, and awards.
ISEF · 2026
Cellular and Molecular Biology
Nonalcoholic fatty liver disease is characterized by excessive lipid accumulation in the liver and can progress to nonalcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carci…
ISEF · 2026
Plant Sciences
Global warming has led to a significant escalation of the rate of coral bleaching, with 90% of reefs projected to experience bleaching annually by 2050. Coral bleaching often occurs when mar…
ISEF · 2026
Cellular and Molecular Biology
Besides the familiar double helix, DNA can form alternative structures such as G-quadruplexes (G4), guanine-rich four-stranded structures that arise during replication and repair. G4s are co…
ISEF · 2026
Robotics and Intelligent Machines
Autonomous robots rely on Simultaneous Localization and Mapping (SLAM) to build maps and estimate their position within unknown environments. While many modern robotic systems achieve high r…
ISEF · 2026
Mathematics
Gerrymandering is the process when congressional district maps are redrawn to benefit a certain political party. This process undermines democracy while giving disproportionate advantage to…
ISEF · 2026
Software Design
Plant diseases, particularly fungal infections, cause significant crop losses worldwide due to delayed detection and limited access to rapid diagnostic tools. This project presents Gharsa, a…
ISEF · 2026
Biomedical Engineering
Migraines are a debilitating neurological condition that impacts over one billion people across the globe, but not enough research or developments on the treatment of migraines have been don…
ISEF · 2026
Biomedical Engineering
Gut motility disorders affect over 20% of the population, but standard diagnostic tools, including endoscopy and manometry, are invasive, expensive, limited to clinical settings, and don’t t…
ISEF · 2026
Biomedical and Health Sciences
Nerve degeneration causes devastating symptoms for millions of patients worldwide. While some peripheral nerves experience recovery, others experience chronic neuropathic pain due to sensory…
ISEF · 2026
Biomedical and Health Sciences
Impaired wound healing is a widespread complication experienced by diabetic patients, with persistent hyperglycemic conditions being a central factor that disrupts cellular repair programs.…
ISEF · 2026
Computational Biology and Bioinformatics
Despite decades of therapeutic development, most disease-associated proteins remain therapeutically inaccessible. These so-called “undruggable” targets typically lack suitable binding pocket…
ISEF · 2026
Mathematics
The Monty Hall problem refers to a question that was asked in the television game, “Let’s Make a Deal”, whose host is Monty Hall. In this question a contestant chooses between three doors, o…
ISEF · 2026
Energy: Sustainable Materials and Design
Solar photovoltaics are the fastest-growing renewable energy source, expected to account for over 16% of global electricity generation by 2050. Conventional silicon solar cells are more carb…
ISEF · 2026
Materials Science
This study aimed to develop an environmentally friendly process to biosynthesize gold nanoparticles (AuNPs) using pomegranate peels, an agro-waste. AuNPs were formed by reducing gold ions wi…
ISEF · 2026
Energy: Sustainable Materials and Design
The transition to a circular carbon economy is hindered by the low energy density of current storage and the inefficiency of biological carbon sequestration. The GSFG-Omni addresses this by…
ISEF · 2026
Biomedical Engineering
Neurocardiological emergencies claim over 18 million lives every year. With out-of-hospital survival dropping 10% every delayed minute, intervening early is critical. However, generalized ph…
ISEF · 2026
Robotics and Intelligent Machines
Aviation emergencies caused by pilot incapacitation remain a critical safety risk, particularly in regions with limited access to advanced automated systems. This project developed H.A.L.O.,…
ISEF · 2026
Engineering Technology: Statics & Dynamics
Approximately 11 million people in the U.S. experience severe hearing loss, yet most hearing individuals do not understand American Sign Language (ASL). HandTalk is a cost-effective interact…
ISEF · 2026
Technology Enhances the Arts
Over 1 Billion people globally live with mental health conditions driving depression & suicide crises. Music therapy is a proven nonpharmacological approach for emotional regulation, yet acc…
ISEF · 2026
Microbiology
Fungal pathogens pose an enormous threat to global health, and a growing number of pathogens are developing resistance to our already limited arsenal of antifungals. Overexpression of efflux…
ISEF · 2026
Environmental Engineering
Globally, pests destroy over 40% of crops annually. Traditional pesticides are highly harmful to the environment and human health, and current application methods—either wasteful mass sprayi…
ISEF · 2026
Biochemistry
BRCA1 is a tumor suppressor protein essential for DNA repair, cell cycle regulation, and the maintenance of genomic stability. Mutations in the BRCA1 gene are strongly associated with an inc…
ISEF · 2026
Microbiology
In today’s world, 1 in 9 people all over the world suffer from diabetes. Out of those people, 1-3 in 9 experience something called diabetic wounds. This project helps biomedical scientists u…
ISEF · 2026
Software Design
This project advances audio augmentation in augmented reality (AR) by developing a music-theoretic spatial sonification method. Although AR is increasingly used in education and entertainmen…
ISEF · 2026
Technology Enhances the Arts
Over 430 million people have some degree of hearing loss . Hearing-impaired individuals use sign language (SL) as their primary communication method, but SL literacy in society is low. This…
ISEF · 2026
Computational Biology and Bioinformatics
Drug-induced liver injury (DILI) accounts for 13% of acute toxicity cases in the U.S. and remains a primary barrier to pharmaceutical development. While most machine learning models predict…
ISEF · 2026
Materials Science
Microbial contamination in cosmetic products such as lipsticks, can lead to health issues and skin irritations due to constant contact with the mouth and exposure to bacteria and fungi. Comm…
ISEF · 2026
Computational Biology and Bioinformatics
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of 12%, driven in part by unresolved mechanisms of therapeutic resistance. While single-cell RNA sequencing has advanced…
ISEF · 2026
Animal Sciences
E-cigarettes are a growing public-health concern, as new studies indicate that heavy metals, including lead, can be found in vape liquid. Despite this desperate need for research, the long-t…
ISEF · 2026
Chemistry
Arsenic contamination in groundwater affects over 200 million people globally. Inorganic arsenic, mainly arsenite (As(III)) and arsenate (As(V)), is classified as a Group 1 human carcinogen,…