Browse real student projects, abstracts, and awards.
ISEF · 2026
Computational Biology and Bioinformatics
Parkinson's disease (PD) affects over 10 million people globally. It is driven by the intrinsically disordered (IDP) protein a-synuclein (asyn). While asyn's flexibility is functional, it en…
ISEF · 2026
Behavioral and Social Sciences
Many teachers have started using phones as a way to encourage students in the classroom. I wondered how effective this method was, and what some of the undesirable consequences could be. The…
ISEF · 2026
Environmental Engineering
Marine oil spills are a severe form of pollution, causing lasting ecological and economic damage. Polypropylene sorbents are non-biodegradable and pose environmental concerns. Thus, our aim…
ISEF · 2026
Software Design
As hyper-realistic deepfakes grow into one of the world’s most pressing crises, the rush to secure digital integrity has made watermarking one of the most urgently researched sectors in cybe…
ISEF · 2026
Biomedical Engineering
This study addresses the prevalent issues of ADHD(attention deficit hyperactivity disorder) and distracted focuses under daily routine; this study aims to bridge the gap between abstract psy…
ISEF · 2026
Translational Medical Science
Triple-negative breast cancer (TNBC) remains a clinical challenge due to its aggressive nature and the lack of targeted therapies. Traf2 and NCK-interacting kinase (TNIK), a key regulator of…
ISEF · 2026
Biomedical and Health Sciences
Human Immunodeficiency Virus (HIV) infection is associated with neurocognitive dysfunction (NeuroHIV), which can occur in 30–50% of people with HIV, despite successful combination antiretrov…
ISEF · 2026
Earth and Environmental Sciences
Polyethylene glycol (PEG) is a synthetic polymer commonly found in cosmetic products such as shampoos and conditioners. Its widespread use raises environmental concerns due to its accumulati…
ISEF · 2026
Translational Medical Science
Meniscus injuries are among the most common orthopedic conditions, with approximately 1 million surgeries annually. Injuries in the avascular zone cannot self-regenerate, and modern scaffold…
ISEF · 2026
Engineering Technology: Statics & Dynamics
This project built upon last year’s research (2024-2025), testing the relationship between the final current (Cf) and the final temperature (Tf) of a cotton candy machine modified for plasti…
ISEF · 2026
Plant Sciences
The conservation of biodiversity in forests is a major challenge globally. Efficient methods for identifying high biodiversity forests are needed to preserve threatened species. This study e…
ISEF · 2026
Earth and Environmental Sciences
Modeling and predicting ocean currents at small scales of less than 50 km help better understand ocean phenomena such as biogeochemical fluxes and nutrient flows. However, this small scale,…
ISEF · 2026
Computational Biology and Bioinformatics
Worldwide, breast cancer kills 700,000 women annually. Although 5 years of tamoxifen (Tam) therapy cuts the risk of progression in half, 40% of patients develop resistance (TamR), driven by…
ISEF · 2026
Physics and Astronomy
Every day, without realizing it, we live immersed in environmental radioactivity, a natural and generally harmless phenomenon. In the past, its strong correlation with meteorological variabl…
ISEF · 2026
Materials Science
The annual generation of 3.8 million tons of shrimp shell waste contributes to environmental toxicity, and microplastics from conventional plastics cause adverse health impacts. To combat th…
ISEF · 2026
Embedded Systems
Modern navigation system is highly dependent on GNSS, which is vulnerable to jamming, spoofing, and geopolitical control. Sovereign navigational satellite system can decrease dependency to f…
ISEF · 2026
Plant Sciences
Modern agriculture faces two challenges: managing agro-industrial waste and reducing reliance on synthetic agrochemicals. The integration of materials science and agricultural biotechnology…
ISEF · 2026
Environmental Engineering
Widespread contamination of surface and groundwater systems from heavy metals, excess nutrients, and other hazardous pollutants has intensified the need for sustainable water remediation tec…
ISEF · 2026
Computational Biology and Bioinformatics
Systemic inflammatory diseases like cirrhosis, ankylosing spondylitis (AS), and hypertension affect over 1 billion people and are often detected after significant organ damage. Growing evide…
ISEF · 2026
Cellular and Molecular Biology
Glioblastoma multiforme (GBM) is one of the most aggressive and rapidly progressing brain tumors. Due to its molecular heterogeneity, it exhibits strong resistance to therapy. Recent studies…
ISEF · 2026
Plant Sciences
Abiotic stresses reduce global crop yields by up to 70%, threatening global food security. While stress-responsive pathways are well studied, the role of deubiquitination in plant developmen…
ISEF · 2026
Biomedical and Health Sciences
Parkinson's disease is a progressive neurodegenerative disorder requiring early intervention, yet screening is often delayed due to a dependency on expensive, in-person clinical assessments.…
ISEF · 2026
Cellular and Molecular Biology
Alzheimer's disease is a neurodegenerative disorder characterized by loss of matter in the brain driven by amyloid-ß (Aß) aggregation. In scientific literature, the role of inhibitory neurot…
ISEF · 2026
Technology Enhances the Arts
This project determined if playing different games in different amounts would affect typing speed and accuracy. The experiment was performed due to personal research that showed an increase…
ISEF · 2026
Biochemistry
Breast cancer remains the most prevalent malignancy among women worldwide. Dose-dense AC-T chemotherapy (Adriamycin, Cyclophosphamide, and Paclitaxel), a commonly prescribed regimen, is asso…
ISEF · 2026
Environmental Engineering
Polyethylene terephthalate (PET) is one of the most common plastics used worldwide, and is used to create products like water bottles, food packaging, and textiles. PET is difficult to break…
ISEF · 2026
Physics and Astronomy
Photonic devices—engineered systems composed of metal-dielectric nanostructures—provide a powerful platform for manipulating and probing the quantum properties of light. These systems suppor…
ISEF · 2026
Computational Biology and Bioinformatics
Brain cancer, or glioblastoma, is one of the most aggressive cancers, given the nutrient-dense environment of the brain. This cancer is very deadly, given the significance of the brain for t…
ISEF · 2026
Biochemistry
Oligonucleotides, especially siRNAs, have been identified as a point of interest in recent research due to their capability for targeting of “undruggable” targets. siRNAs bind to and guide t…
ISEF · 2026
Computational Biology and Bioinformatics
Autism Spectrum Disorder (ASD) exhibits substantial heterogeneity in long-term developmental outcomes. Children with similar early symptoms often follow divergent cognitive and adaptive-func…