20,037 real projects from ISEF, the Canada-Wide Science Fair, JSHS and the Calgary Youth Science Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2018
Translational Medical Science Third Award
WHO estimates that around 12 million children (2-5% children worldwide) suffer from amblyopia - the most common visual impairment among children. Neurocognitive development is dependent on p…
ISEF · 2018
Biomedical and Health Sciences Third Award
Glioblastoma is the most common and aggressive type of brain tumor in adults, primarily treated with the chemotherapeutic agent Temozolomide (TMZ). However, many tumors are initially resista…
ISEF · 2018
Biomedical and Health Sciences Third Award
Background/Hypothesis: Multiple system atrophy (MSA) is a fatal neurodegenerative disorder with unknown mechanisms and no curative treatment. The rationale for this work came from a clinical…
ISEF · 2018
Biomedical and Health Sciences
When diagnosing intraductal lesions in breast tissue, pathologists evaluate architectural, morphologic and at times immunohistochemical features to classify the disease. However, in the medi…
ISEF · 2018
Biomedical and Health Sciences
Hypertrophic cardiomyopathy (HCM) is a common heart disease that causes sudden cardiac arrest in people of all ages. In this research, we tested six chemotherapy drugs that reinforced separa…
ISEF · 2018
Translational Medical Science
This study aimed to detect corneal arcus. The detection of corneal arcus by image analysis has important signi?cance for the disintegration of abnormal lipid metabolism. Corneal arcus is a l…
ISEF · 2018
Biomedical and Health Sciences First Award
The student researcher previously concluded that East Indian Sandalwood Oil (EISO) inhibits AGS gastric cancer cells by inhibiting a TRPM7-like ion channel recorded via automated patch clamp…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Alzheimer’s dementia (AD) is a neurodegenerative disease that affects one out of three seniors. It has killed more people than breast and prostate cancer together, making it the sixth leadin…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Despite increased research and treatment options, cancer continues to increase. To test treatments for this deadly disease, 2D microenvironments are currently used in lab settings. Only 10%…
ISEF · 2018
Translational Medical Science
Liver Fibrosis is the creation of scar tissue in the liver after it suffers damage, and it can lead to cirrhosis and hepatocellular cancer. There are currently no standard treatments for liv…
ISEF · 2018
Biomedical and Health Sciences
Sepsis affects microcirculation and tissue perfusion leading to tissue hypoxia and multiple organ dysfunction. Red blood cells (RBCs) play the critical role of tissue oxygenation, thus funct…
ISEF · 2018
Biomedical and Health Sciences
Tauopathies, for example Alzheimer’s disease (AD), affect over 5.5 million Americans, and are estimated to affect 16 million people by 2050. Tauopathies are diseases caused by the damage of…
ISEF · 2018
Biomedical and Health Sciences Third Award
The purpose of this experiment was to compare seven coronary rotational atherectomy device head designs (spherical with 3, 4, or 5-holes, conical with 3, 4, or 5-holes, & control with no hol…
ISEF · 2018
Translational Medical Science Third Award
The increase in the global population, an increase of elderly, combined with new surgical interventions and possibilities lead to an overall increase of surgeries. Every year there over 50 m…
ISEF · 2018
Translational Medical Science
Programmed Death Ligand 1, or PD-L1, is a transmembrane protein upregulated in numerous tumors. By binding to the PD-1 receptors on CD8+ T-cells, these tumors can evade T-cells’ cytotoxic ef…
ISEF · 2018
Translational Medical Science
MIT researchers stimulated gamma waves in genetically modified mice brains with flashing lights to trigger microglia to clean up beta amyloid plaques (the cause of Alzheimer’s Disease). The…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Topotecan (TPT) is a chemotherapeutic drug frequently used to treat lung cancer, which is the leading cause of cancer-related death in the US. However, the development of drug resistance in…
ISEF · 2018
Biomedical and Health Sciences
Mesenchymal stem cells (MSCs) present a high degree of clonal heterogeneity, making it difficult to identify which cells are capable of repopulating tissues versus those more prone to underg…
ISEF · 2018
Biomedical and Health Sciences
Purpose: Lung Cancer is the leading cause of cancer related death among men and women. M2 macrophages are known suppressors of host anti-tumor immune functions and promote primary growth and…
ISEF · 2018
Biomedical and Health Sciences
BACKGROUND: Peanut allergy therapies, such as EpiPens, treat anaphylactic reactions, but do not cure allergies. Previously, altering a monomicrobial microbiome with Bacteroides fragilis damp…
ISEF · 2018
Biomedical and Health Sciences
Type 2 Diabetes mellitus is a serious global health problem that is characterized by postprandial hyperglycemia. Presently, long-term use of commercial drugs in the management of diabetes ha…
ISEF · 2018
Translational Medical Science First Award
Heart disease is the leading cause of death worldwide (WHO), and experts estimate that half of all heart attacks and strokes occur in people who have not been flagged as ‘at risk'. There is…
ISEF · 2018
Translational Medical Science Fourth Award
Chemotherapy continues to play an important role in treating various cancers; however, during the course of treatment it is often challenging to differentiate between cancerous and healthy t…
ISEF · 2018
Translational Medical Science
Kyphosis is the excessive curvature of the thoracic spine along the sagittal plane, creating a hunchback or slouching appearance. It is a pressing issue in modern society due to anatomical i…
ISEF · 2018
Translational Medical Science
Sucrose in combination with Streptococcus mutans result in acids which break down enamel and contribute to dental caries. Alternatives with potential oral health benefits were explored in th…
ISEF · 2018
Biomedical and Health Sciences Third Award
Type 2 diabetes (T2D), a metabolic disorder characterized by high blood sugar and insulin resistance (IR), has serious socioeconomic ramifications. While T2D is considered a lifestyle diseas…
ISEF · 2018
Biomedical and Health Sciences
Purpose: Stroke is a fatal neurological disease causing severe long-term functional disability in patients. The incident of stroke is rising exponentially, irrespective of age. The beneficia…
ISEF · 2018
Biomedical and Health Sciences
Studying metabolic functions of cancer cells can reveal novel treatment options. For example, increased glutamine uptake drives cancer cell proliferation. The first step in glutamine utiliza…
ISEF · 2018
Translational Medical Science
Chronic inflammation can lead to the buildup of proinflammatory cytokines and result in a plethora of diseases from arthritis to asthma. This has led to a need for safe and natural anti-infl…
ISEF · 2018
Biomedical and Health Sciences
HER2 is a membrane bound protein receptor for cell proliferation. When present in excess, the cell divides uncontrollable and leads to cancer. This type of cancer is very prone to recurrence…