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Can the Immune System Be Reprogrammed to Eradicate MS Using Novel Biologics ?

AJAS · 2019 Biomedical and Health Sciences (inferred)

Rojin Shirwan · Kentucky Academy of Science

Overview

Abstract Multiple sclerosis (MS) is a chronic, demyelinating autoimmune disease of the central nervous system (CNS) initiated and perpetuated by T cells responding to a number of myelin antigens. An imbalance between the number of pathogenic T effector (Teff) cells and protective T regulatory (Treg) cells is the underlying cause of the disease. Reversing this balance in favor of Treg cells has significant potential as a curative treatment. The present study is designed to achieve this goal using two novel proprietary biologics, a death receptor agonist (SA-FasL) and Treg cell growth factor (SA-IL2/IL-2). SA-FasL specifically targets Teff cells for physical depletion, while IL-2 expands and improves the survival of Treg cells. These two biologics are produced using an insect expression system and used in mouse model to stop the induced MS diseases. Our preliminary studies have shown that the treatment with biologics are effective for the treatment of established diseases.

Competition history

  • AJAS 2019 Category not listed

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Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

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