Browse real student projects, abstracts, and awards.
ISEF · 2025
Biomedical and Health Sciences
Early diagnosis of neurodevelopmental disorders (NDDs) such as Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) enables early intervention and is crucial fo…
ISEF · 2025
Translational Medical Science
The use of therapeutic siRNA to silence genes in a sequence-specific manner has been limited by its need for delivery to target cells. However, while antibody-mediated siRNA delivery shows p…
ISEF · 2025
Biomedical and Health Sciences
Late-stage keratoconus is a progressive corneal disease causing severe visual loss. Conventional treatments, like corneal rings, often fail in advanced cases due to insufficient tensile stre…
ISEF · 2025
Translational Medical Science
95% of chronic kidney disease (CKD) patients miss early detection, mostly diagnosed at late stages, contributing to an annual mortality of 11 million globally. Current screening methods, suc…
ISEF · 2025
Translational Medical Science
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, affecting 20 million in the US alone. Retinal Pigment Epithelial (RPE) cells between the reti…
ISEF · 2025
Biomedical and Health Sciences
Pancreatic cancer is the second leading cause of death, with 90% of occurrences as Pancreatic ductal adenocarcinoma (PDAC). Currently, Doxorubicin (DOX) is the leading treatment for cancers.…
ISEF · 2025
Translational Medical Science
Purpose: Patients with breast cancer (BC) who undergo neoadjuvant therapy (NAT) before surgery and achieve a pathologic complete response (pCR) after NAT have a low rate of recurrence. Howev…
ISEF · 2025
Translational Medical Science
Each year, 1.9 million people worldwide are diagnosed with colorectal cancer, and early detection of cancerous polyps is crucial for treatment. Endoscopic imaging is a critical part of ident…
ISEF · 2025
Translational Medical Science
In 2024 the American Cancer Society (ACS) reported a 78% death rate for pancreatic cancer. The 5-year survival rate for pancreatic cancer is 13%. ACS states the only effective method known t…
ISEF · 2025
Biomedical and Health Sciences
Leigh Syndrome (LS) is a rare mitochondrial disorder caused by mutations in the SURF1 gene, leading to reduced Complex IV enzymatic activity, impaired oxidative phosphorylation, and severe m…
ISEF · 2025
Biomedical and Health Sciences
Glioblastoma (GBM) is the most predominant malignant brain cancer in adults without prognosis improvement in decades. Nevertheless, 83% of GBM cases have Telomerase Reverse Transcriptase pro…
ISEF · 2025
Translational Medical Science
Recent advancements in extended reality (XR), encompassing augmented reality (AR), virtual reality (VR), and mixed reality (MR), have demonstrated significant potential in transforming the m…
ISEF · 2025
Biomedical and Health Sciences
Breast cancer is the most common cancer worldwide and a complex disease characterized by genetic heterogeneity. Despite advancements in cancer management, the risk of recurrence and death re…
ISEF · 2025
Biomedical and Health Sciences
STAC3, known as Native American Myopathy, was first identified within the Lumbee tribe of North Carolina and is known to be an inherited mutation that causes congenital myopathy and musculos…
ISEF · 2025
Biomedical and Health Sciences
Helicobacter pylori is a bacterial strain that attaches to gastric mucosal cells through its BabA adhesin, which begins growth of colonies that increase risk of peptic ulcers and gastric or…
ISEF · 2025
Translational Medical Science
CTE, a progressive neurodegenerative condition from repetitive head impacts in sports, lacks preventive interventions. This research examines curcumin and CoQ10's neuroprotective effects in…
ISEF · 2025
Biomedical and Health Sciences
The therapeutic value of traditional plants in the Philippines remains underexplored. Thus, this study investigates the neuroprotective potential of Premna odorata leaf extract for Alzheimer…
ISEF · 2025
Translational Medical Science
The widespread use of drugs, together with their limited specificity and poor biodistribution, poses significant challenges. Antibiotic resistance, aggravated by decades of uncontrolled cons…
ISEF · 2025
Biomedical and Health Sciences
Cardiovascular disease (CVD) causes 20.5 million deaths annually and imposes significant economic burdens due to rising healthcare costs. While pharmacological treatments and surgeries are t…
ISEF · 2025
Translational Medical Science
Cancer is the second leading cause of death worldwide, affecting 20 million people and being responsible for >9.7 million deaths annually. Early prediction of clinical outcomes is crucial fo…
ISEF · 2025
Biomedical and Health Sciences
The study analyzed the antioxidant content in teas, coffees, red wines, and various fruits. The biological effect of antoxidants includes antibacterial, antiviral, anti-inflammatory, antiall…
ISEF · 2025
Translational Medical Science
Osteoarthritis (OA) is a chronic inflammatory joint disease affecting over 500 million people, leading to cartilage degeneration and severe pain. Current treatments are invasive, costly, and…
ISEF · 2025
Biomedical and Health Sciences
Researcher's acquaintance has ADHD and takes Adderall and shared that its effect (attention improvement) reaches a peak and drops quickly, resulting in having to time pill’s intake with upco…
ISEF · 2025
Biomedical and Health Sciences
Model for End-Stage Liver Disease (MELD)score, a widely used tool, predicts 90-day waitlist-mortality but fails to account for post-transplant survival, leading to suboptimal organ allocatio…
ISEF · 2025
Translational Medical Science
Cytomegalovirus (CMV) is a betaherpesvirus that is typically latent in a human host, but presents dangerously in immunocompromised patient populations. CMV primary infection or reactivation…
ISEF · 2025
Translational Medical Science
Early detection is crucial for establishing a positive prognosis and outcome for cancer patients. Widely used detection methods, such as tissue biopsies and imaging, are cost-prohibitive, cu…
ISEF · 2025
Translational Medical Science
Oral cancer affects over 300,000 people worldwide each year and has a mortality rate of approximately 47%. Early diagnosis can significantly improve survival rates by up to 56%, but less tha…
ISEF · 2025
Translational Medical Science
Acquired drug resistance is one of the biggest obstacles in cancer treatment, leading to increased chances of cancer relapses and progression. To combat drug resistances and to improve treat…
ISEF · 2025
Translational Medical Science
The accumulation of amyloid-beta (AB) plaques and tau protein tangles are defining pathological features of Alzheimer’s disease (AD). In previous studies, AB plaques and tau tangles have bee…
ISEF · 2025
Translational Medical Science
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. Early diagnosis and efficient rehabilitation are critical, while current methods of in person clinical consul…