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Investigating Differentially Expressed Genes and Sex-Specific Genes in Lung Cancer

AJAS · 2025 Biomedical and Health Sciences (inferred)

Harriet Lai · Southern California Academy of Sciences

Overview

Lung cancer is a life-threatening disease that affects hundreds of thousands of patients every year. While conventional medicine offers effective treatments for lung cancer, the use of targeted therapy can offer patients a more favorable treatment by being equally effective and by minimizing the side effects the patient experiences. The purpose of this research is to identify any differentially expressed or sex-specific genes in lung adenocarcinoma (LUAD) that can act as potential targets. Using transcriptome profiles of LUAD tissues from The Cancer Genome Atlas, these profiles are analyzed using the TCGABiolinks library. The differentially expressed genes are used to generate gene ontology, create protein association networks, and find survival plots of genes using Metascape, STRING, and the Human Protein Atlas respectively. Similar procedures were used for the sex-specific analysis. The gene ontology analysis showed that the TFAP2 family of transcription factors and the PID HNF3B pathway likely promote tumorigenesis in LUAD. Moreover, AGER and SFTPC, both genes involved in lung development, were underexpressed in all LUAD samples, and patients with a higher expression of these genes had a significantly higher survival rate than others, making them potential prognostic markers. Looking into the sex-specific genes, it was found that members of the MAGE-A family, a testis antigen family, were highly up-regulated in both males and females. The dysregulation of these genes in females might have a specific role in LUAD progression. These findings can be investigated further to develop better treatments to cure the cause or alleviate symptoms of the disease.

Competition history

  • AJAS 2025 Category not listed

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Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

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