20,037 real projects from ISEF, the Canada-Wide Science Fair, JSHS and the Calgary Youth Science Fair — searchable by meaning, and filterable by fair, year, category and award.
CWSF · 2026
Health & Wellness
The human Y chromosome is one of the least understood parts of the human genome, mainly because it is very repetitive, making it difficult to sequence accurately. With the release of new hum…
ISEF · 2026
Biomedical and Health Sciences
Per- and polyfluoroalkyl substances (PFAS) are highly persistent fluorinated chemicals used in many consumer and industrial products that are prone to bioaccumulation due to strong C-F bonds…
CWSF · 2026
Disease & Illness Silver Medal
Cystic fibrosis is a disease that causes difficulty breathing and digestive problems because a certain protein in the body is mutated and therefore does not work properly. Using computationa…
CWSF · 2026
Disease & Illness Bronze Medal
Human rabies is a zoonotic viral disease transmitted from animals to humans, and is virtually 100% fatal post-symptom onset, primarily due to the virus's ability to evade the immune system a…
ISEF · 2026
Translational Medical Science
Medulloblastoma is the most prevalent malignant brain tumor in children, and 75% of children that have it are under the age of ten. However, its current treatments are surgery, chemotherapy,…
ISEF · 2026
Translational Medical Science
Creutzfeldt-Jakob Disease (CJD) is a deadly neurodegenerative disease caused by prion proteins (PrPSC), which trigger normal cellular proteins to misfold, resulting in aggregation and neuron…
CWSF · 2026
Disease & Illness Gold Medal
Antibiotic resistance is one of the most urgent crises in global health, and the first step in fighting it is correctly identifying whether a bacterium is Gram-positive or Gram-negative — a…
ISEF · 2026
Translational Medical Science
Dry eye disease (DED) is increasingly understood as a disorder involving both ocular surface inflammation and corneal nerve damage. Although platelet-rich plasma (PRP) and cenegermin (Oxerva…
CWSF · 2026
Disease & Illness Gold Medal
2.3 million women are diagnosed with breast cancer every year, world wide. One of the main tools to decide the treatment is tumor grade, or aggressiveness of the cancer cells. Yet, the patho…
ISEF · 2026
Biomedical and Health Sciences
COVID-19 infection causes disordered sugar metabolism, both in acute infection and long COVID. Diabetic COVID-19 patients with hyperglycemia have higher mortality rates, and infection elevat…
ISEF · 2026
Translational Medical Science
GLP-1 receptor agonists are widely used to treat diabetes and obesity and are being investigated for potential cognitive benefits in Alzheimer's disease. However, these treatments simultaneo…
CWSF · 2026
Disease & Illness Silver Medal
Bloodstream infections are life-threatening and frequently bacterial, requiring rapid initiation of species-specific antibiotic treatment. Gram staining provides initial bacterial characteri…
ISEF · 2026
Biomedical and Health Sciences
Each year, about 58,500 Americans are diagnosed with oral or oropharyngeal cancer, and over 12,000 of them will not survive it. When oral cancer is caught at a localized stage, the 5-year su…
CWSF · 2026
Disease & Illness
Chaque année, environ 15 millions de nouveau-nés naissent prématurément à travers le monde. Parmi eux, les grands prématurés, nés à 22 semaines de gestation, se trouvent dans une situation p…
CWSF · 2026
Disease & Illness Silver Medal
Undetected and untreated infected wounds are a global leading cause of undiagnosed illness, especially in developing countries. Derma-Heal is designed to address this unattended crisis by de…
ISEF · 2026
Biomedical and Health Sciences
Women are often medicated according to the male body. Throughout history, women have been underrepresented in clinical trials within medical research, and drugs have been developed based on…
ISEF · 2026
Biomedical and Health Sciences
Leukemia remains a leading cause of global cancer mortality, with Acute Myeloid Leukemia (AML) presenting the most aggressive clinical profile with frequent relapse even after treatment. Ove…
ISEF · 2026
Translational Medical Science
Inflammatory bowel disease (IBD), which encompasses Crohn's disease and ulcerative colitis, affects about 5 million people worldwide and is caused by the inflammation of the gastrointestinal…
ISEF · 2026
Translational Medical Science
Background: Skin aging is a natural biological process that was cause by a comprehensive combination of intrinsic and extrinsic factors. This process varies a lot among individuals and often…
ISEF · 2026
Translational Medical Science
Every 3 seconds, a new case of dementia is diagnosed worldwide, and more than 55 million people live with dementia, underscoring the need for innovative, accessible complementary strategies…
ISEF · 2026
Translational Medical Science
The prevalence of Alzheimer's disease (AD), a multifactorial, neurodegenerative disease characterized by a decline in cognitive functions, is projected to double by 2060, underscoring a grow…
CWSF · 2026
Health & Wellness
I started my science fair project last year. I used a smartwatch to monitor my REM sleep. I ate different types of food before bed to see if it would affect my sleep cycle. The smartwatch I…
CWSF · 2026
Disease & Illness
Congenital heart defects (CHDs), which affect nearly 1% of live births worldwide, arise from disruptions in tightly regulated signaling pathways governing early cardiac morphogenesis. This p…
CWSF · 2026
Health & Wellness Bronze Medal
In this digital age, we give away our data everyday; by accepting website cookies or wearing smartwatches that track everything from heart rate to sleep cycles. The data we generate can be u…
CWSF · 2026
Disease & Illness
Lipid nanoparticles (LNPs) are an important component of a leading drug delivery system. They protect the medicine they carry, increasing its bioavailability and stability and notably used i…
ISEF · 2026
Biomedical and Health Sciences
Traumatic brain injuries (TBIs) are a major public health concern within the United States alone, with approximately 2.5 million cases reportedly annually (CNS, 2021). TBIs contribute to sig…
CWSF · 2026
Disease & Illness
Ultrasound imaging is an advanced tool used to examine internal structures of the human body, while light imaging is commonly used in laboratories to examine smaller structures. But how well…
CWSF · 2026
Health & Wellness Platinum Award
When my father was hospitalized, overworked staff struggled to check his vitals regularly. That experience led me to remote heart-rate monitoring, then to a deeper problem: optical heart-rat…
CWSF · 2026
Disease & Illness
Le GBA1 est un gène associé à la maladie de Parkinson qui n’est que partiellement comprise même à ce jour. Pour tenter de tirer au clair les effets de l’inflammation et du silençage du GBA1,…
CWSF · 2026
Disease & Illness
Millions of people are affected by chronic wounds each year because they are extremely difficult to treat due to protective biofilms that block treatment. Current wound care methods are ofte…