Browse real student projects, abstracts, and awards.
ISEF · 2018
Biomedical and Health Sciences
Tauopathies, for example Alzheimer’s disease (AD), affect over 5.5 million Americans, and are estimated to affect 16 million people by 2050. Tauopathies are diseases caused by the damage of…
ISEF · 2018
Biomedical and Health Sciences Third Award
The purpose of this experiment was to compare seven coronary rotational atherectomy device head designs (spherical with 3, 4, or 5-holes, conical with 3, 4, or 5-holes, & control with no hol…
ISEF · 2018
Translational Medical Science Third Award
The increase in the global population, an increase of elderly, combined with new surgical interventions and possibilities lead to an overall increase of surgeries. Every year there over 50 m…
ISEF · 2018
Translational Medical Science
Programmed Death Ligand 1, or PD-L1, is a transmembrane protein upregulated in numerous tumors. By binding to the PD-1 receptors on CD8+ T-cells, these tumors can evade T-cells’ cytotoxic ef…
ISEF · 2018
Translational Medical Science
MIT researchers stimulated gamma waves in genetically modified mice brains with flashing lights to trigger microglia to clean up beta amyloid plaques (the cause of Alzheimer’s Disease). The…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Topotecan (TPT) is a chemotherapeutic drug frequently used to treat lung cancer, which is the leading cause of cancer-related death in the US. However, the development of drug resistance in…
ISEF · 2018
Biomedical and Health Sciences
Mesenchymal stem cells (MSCs) present a high degree of clonal heterogeneity, making it difficult to identify which cells are capable of repopulating tissues versus those more prone to underg…
ISEF · 2018
Biomedical and Health Sciences
Purpose: Lung Cancer is the leading cause of cancer related death among men and women. M2 macrophages are known suppressors of host anti-tumor immune functions and promote primary growth and…
ISEF · 2018
Biomedical and Health Sciences
BACKGROUND: Peanut allergy therapies, such as EpiPens, treat anaphylactic reactions, but do not cure allergies. Previously, altering a monomicrobial microbiome with Bacteroides fragilis damp…
ISEF · 2018
Biomedical and Health Sciences
Type 2 Diabetes mellitus is a serious global health problem that is characterized by postprandial hyperglycemia. Presently, long-term use of commercial drugs in the management of diabetes ha…
ISEF · 2018
Translational Medical Science First Award
Heart disease is the leading cause of death worldwide (WHO), and experts estimate that half of all heart attacks and strokes occur in people who have not been flagged as ‘at risk'. There is…
ISEF · 2018
Translational Medical Science Fourth Award
Chemotherapy continues to play an important role in treating various cancers; however, during the course of treatment it is often challenging to differentiate between cancerous and healthy t…
ISEF · 2018
Translational Medical Science
Kyphosis is the excessive curvature of the thoracic spine along the sagittal plane, creating a hunchback or slouching appearance. It is a pressing issue in modern society due to anatomical i…
ISEF · 2018
Translational Medical Science
Sucrose in combination with Streptococcus mutans result in acids which break down enamel and contribute to dental caries. Alternatives with potential oral health benefits were explored in th…
ISEF · 2018
Biomedical and Health Sciences Third Award
Type 2 diabetes (T2D), a metabolic disorder characterized by high blood sugar and insulin resistance (IR), has serious socioeconomic ramifications. While T2D is considered a lifestyle diseas…
ISEF · 2018
Biomedical and Health Sciences
Purpose: Stroke is a fatal neurological disease causing severe long-term functional disability in patients. The incident of stroke is rising exponentially, irrespective of age. The beneficia…
ISEF · 2018
Biomedical and Health Sciences
Studying metabolic functions of cancer cells can reveal novel treatment options. For example, increased glutamine uptake drives cancer cell proliferation. The first step in glutamine utiliza…
ISEF · 2018
Translational Medical Science
Chronic inflammation can lead to the buildup of proinflammatory cytokines and result in a plethora of diseases from arthritis to asthma. This has led to a need for safe and natural anti-infl…
ISEF · 2018
Biomedical and Health Sciences
HER2 is a membrane bound protein receptor for cell proliferation. When present in excess, the cell divides uncontrollable and leads to cancer. This type of cancer is very prone to recurrence…
ISEF · 2018
Biomedical and Health Sciences
The studies suggest that in 2050 there will be 9 billion people on Earth. The global expansion of the population and wasteful consumption are going to increase the pressure on future food su…
ISEF · 2018
Translational Medical Science
The purpose of this project was to find an alternative method protocol to treat infections caused by the following pathogens: Escherichia coli, Methicillin-resistant Staphylococcus aureus, a…
ISEF · 2018
Biomedical and Health Sciences
The FOXO transcription factors are part of the Forkhead subfamily O, which contain four members: (FOXO1, FOXO3, FOXO4, and the less well conserved FOXO6) that regulate gene expression involv…
ISEF · 2018
Translational Medical Science
Ketosis is a metabolic state in which some of the body’s energy supply comes from ketone bodies, a product of the breakdown of stored triglycerides. Uncontrolled ketosis leads to an excessiv…
ISEF · 2018
Translational Medical Science
Lack of effective treatment and substantial side effects of current chemotherapy have resulted in poor prognosis for triple-negative breast cancer (TNBC) patients. To avoid these side effect…
ISEF · 2018
Biomedical and Health Sciences
Duchenne muscular dystrophy (DMD) is a severe genetic muscle degeneration disease. Although it is known that DMD is caused by an absence of the protein dystrophin, the exact mechanism of mus…
ISEF · 2018
Biomedical and Health Sciences
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that causes devastating memory loss and cognitive decline in humans. There is no current cure for AD. Research studies sho…
ISEF · 2018
Translational Medical Science Second Award
The goals of this study were to develop a Drosophila melanogaster model of traumatic brain injury (TBI) using the “High Impact Trauma” (HIT) device to inflict injury and induce vacuolar lesi…
ISEF · 2018
Translational Medical Science
Phenytoin is a commonly used antiepileptic drug. Its effect on causing gingival overgrowth with a prevalence of 50%. This problem caries both hygiene and cosmetic impact on patients. The aim…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
When cancer spreads from one organ to another, it becomes significantly harder to treat. This process, known as metastasis, is involved in 90% of cancer deaths. Because metastasis presents a…
ISEF · 2018
Translational Medical Science
Bacterial vaginosis is a very prevalent women's health issue that affects millions of women worldwide every year, and many current treatments are messy, inconvenient, and ineffective. Theref…