Browse real student projects, abstracts, and awards.
ISEF · 2018
Biomedical and Health Sciences
Chemotherapy, a major cancer treatment approach, suffers seriously from multidrug resistance (MDR), generally caused by innate DNA repair proteins or transmembrane efflux proteins that remov…
ISEF · 2018
Translational Medical Science First Award
Bruxism, the involuntary grinding and/or clenching of teeth, is a condition which often goes undiagnosed until irreversible damage occurs. Although research on this topic has been extensive,…
ISEF · 2018
Translational Medical Science
Cancer is one of the most prevalent diseases affecting humans today and its lack of early diagnosis is leading to many millions of deaths worldwide. Hypothesis, in order to help people scree…
ISEF · 2018
Biomedical and Health Sciences
Coeliacs are required to follow a strict gluten free diet, to prevent damage to the small intestine. This experiment investigated the efficacy of two gluten digestive dietary supplements in…
ISEF · 2018
Biomedical and Health Sciences
The purpose of this project was to determine the effect of yeast-derived beta-glucan stimulation on the cytokine production and tumoricidal effect of macrophages. It was hypothesized that be…
ISEF · 2018
Biomedical and Health Sciences
Derivatives of cobalamin (Vitamin B-12) are important to the function of enzymes required for metabolism. Failure to convert cobalamin into its derivative forms leads to build up of methylma…
ISEF · 2018
Translational Medical Science
Ovarian cancer affects countless women worldwide. Unfortunately, systemic chemotherapy for treatment of ovarian cancer necessitates one-time super dosing, leading to the onset of severe side…
ISEF · 2018
Translational Medical Science
Rambutan fruit is a local fruit that can be found abundantly in Malaysia. The skin of rambutan has been reported to possess few phyto-constituents that has anti-cancer properties. Hence, the…
ISEF · 2018
Translational Medical Science
Lung cancer is the second most common cancer and accounts for 1 in 4 cancer deaths. Sulindac is an FDA approved anti-inflammatory drug. Metformin is an anti-diabetes drug which is also FDA a…
ISEF · 2018
Translational Medical Science Third Award
Alzheimer’s disease (AD) is a neurodegenerative, fatal brain disease characterized by impairments in memory, language, reasoning, and cognition. Identifying AD in its earliest stages of Mild…
ISEF · 2018
Translational Medical Science
Convolutional Neural Networks (CNNs) are machine learning systems that can classify images. Applying CNNs to medical images for recognizing different types of skin lesions can ultimately cre…
ISEF · 2018
Biomedical and Health Sciences
Cardiovascular diseases are the leading cause of death in the world. Atherosclerosis, the buildup of plaque on artery walls, is the precursor to many cardiovascular diseases. Unfortunately,…
ISEF · 2018
Translational Medical Science Second Award
Development of a Drug-likeness Rule for Natural Products Saadh Ahmed Northview High School, Johns Creek , GA, USA In the field of drug discovery, the first steps are crucial to the overall s…
ISEF · 2018
Translational Medical Science
Powassan virus is a causative agent of tick-borne encephalopathy that has shown a 375% increase in the United States in the last five years alone. There is currently no cure for infection by…
ISEF · 2018
Translational Medical Science Fourth Award
Curcumin has gained prominence for its pharmacological and medicinal applications, including antioxidant and anticarcinogenic properties. However, its low oral-bioavailability and stability…
ISEF · 2018
Translational Medical Science
Diseases are diagnosed based on physical attributes that define the disease. Many diseases such as cancer rely on invasive methods such as biopsy for detection. Others are hard to detect ear…
ISEF · 2018
Biomedical and Health Sciences
The most common cause of Acute Myeloid Leukemia is the mutation of the NPM1 protein. Cells can only differentiate when NPM1 is in the nucleus because the protein NPM1 carries with it master…
ISEF · 2018
Biomedical and Health Sciences
The reason for this science fair project was to see if body mass index (BMI), stomach girth, and skinfold measurements indicated whether individuals are pre-disposed to diabetes. The hypothe…
ISEF · 2018
Biomedical and Health Sciences
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the human gastrointestinal tract with no known cure; periods of subsided inflammation are followed by periods of hyper…
ISEF · 2018
Translational Medical Science Third Award
WHO estimates that around 12 million children (2-5% children worldwide) suffer from amblyopia - the most common visual impairment among children. Neurocognitive development is dependent on p…
ISEF · 2018
Biomedical and Health Sciences Third Award
Glioblastoma is the most common and aggressive type of brain tumor in adults, primarily treated with the chemotherapeutic agent Temozolomide (TMZ). However, many tumors are initially resista…
ISEF · 2018
Biomedical and Health Sciences Third Award
Background/Hypothesis: Multiple system atrophy (MSA) is a fatal neurodegenerative disorder with unknown mechanisms and no curative treatment. The rationale for this work came from a clinical…
ISEF · 2018
Biomedical and Health Sciences
When diagnosing intraductal lesions in breast tissue, pathologists evaluate architectural, morphologic and at times immunohistochemical features to classify the disease. However, in the medi…
ISEF · 2018
Biomedical and Health Sciences
Hypertrophic cardiomyopathy (HCM) is a common heart disease that causes sudden cardiac arrest in people of all ages. In this research, we tested six chemotherapy drugs that reinforced separa…
ISEF · 2018
Translational Medical Science
This study aimed to detect corneal arcus. The detection of corneal arcus by image analysis has important signi?cance for the disintegration of abnormal lipid metabolism. Corneal arcus is a l…
ISEF · 2018
Biomedical and Health Sciences First Award
The student researcher previously concluded that East Indian Sandalwood Oil (EISO) inhibits AGS gastric cancer cells by inhibiting a TRPM7-like ion channel recorded via automated patch clamp…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Alzheimer’s dementia (AD) is a neurodegenerative disease that affects one out of three seniors. It has killed more people than breast and prostate cancer together, making it the sixth leadin…
ISEF · 2018
Biomedical and Health Sciences Fourth Award
Despite increased research and treatment options, cancer continues to increase. To test treatments for this deadly disease, 2D microenvironments are currently used in lab settings. Only 10%…
ISEF · 2018
Translational Medical Science
Liver Fibrosis is the creation of scar tissue in the liver after it suffers damage, and it can lead to cirrhosis and hepatocellular cancer. There are currently no standard treatments for liv…
ISEF · 2018
Biomedical and Health Sciences
Sepsis affects microcirculation and tissue perfusion leading to tissue hypoxia and multiple organ dysfunction. Red blood cells (RBCs) play the critical role of tissue oxygenation, thus funct…