Browse real student projects, abstracts, and awards.
ISEF · 2020
Translational Medical Science
Background: Neoadjuvant chemotherapy (NAC) is often used as treatment for mid to late stage breast cancer prior to surgery. However, it is currently not possible to determine accurately or r…
ISEF · 2020
Biomedical and Health Sciences
Cancer biomarkers are measurable variables indicative of disease presence or progression. However, inadequate methods of biomarker identification combined with the underlying complexity of c…
ISEF · 2020
Biomedical and Health Sciences
With a dismal five-year survival rate of 8%, pancreatic cancer remains one of the most lethal epithelial cancers. A growing body of evidence suggests that deformities in cell-cell junctions…
ISEF · 2020
Translational Medical Science
Parkinson's disease is a neurodegenerative disorder that eventually deprives an individual of normal movement, affecting over ten million people worldwide. As it progresses, the person with…
ISEF · 2020
Translational Medical Science
Heart diseases are the number one cause of deaths globally, with three-quarters occurring in developing countries (WHO). In India, heart-related mortality rates in rural areas have surpassed…
ISEF · 2020
Biomedical and Health Sciences
Drug delivery devices specifically transport drugs to help reduce drug toxicity to healthy cells and repetitive drug administrations. This study analyzes the use of pH-responsive nanogels, p…
ISEF · 2020
Biomedical and Health Sciences
Gut epithelium turns over rapidly due to damage from digestion and toxins produced by the enteric microbiota. The rapid turnover process of gut epithelium is tightly regulated. Dysfunction o…
ISEF · 2020
Translational Medical Science
Beta-secretase (BACE), an enzyme responsible for the endoproteolysis of amyloid precursor protein to produce the hallmark amyloid-beta plaques of Alzheimer's pathology, has been of considera…
ISEF · 2020
Translational Medical Science
Currently, there is no fully reliable or accurate way to determine whether an individual has Parkinson’s disease. Moreover, 90% of clinically-confirmed Parkinson’s disease cases are idiopath…
ISEF · 2020
Biomedical and Health Sciences
Arsenic is a known carcinogen, which can be ingested through contaminated drinking water. Most studies in the high-level arsenic range have found a significant correlation between arsenic in…
ISEF · 2020
Translational Medical Science
Cognitive deterioration caused by Mild Cognitive Impairment (MCI), which is often a transition between regular aging and neurodegenerative disease (Alzheimer’s disease), is displayed before…
ISEF · 2020
Translational Medical Science
When skin cancer metastasizes the survival rate drops to 23%, so targeting skin cancer before this happens is paramount. E4orf4 is a gene that allows viruses to regulate gene expression, in…
ISEF · 2020
Biomedical and Health Sciences
Alzheimer’s disease (AD), the most common form of senile dementia, is one of the leading causes of death in the U.S. A predisposition or expression of chronic stress-related symptoms has bee…
ISEF · 2020
Biomedical and Health Sciences
Autoimmune diseases, including Rheumatoid Arthritis and Systemic Lupus Erythematosus, are characterized by symptoms of chronic tissue swelling and inflammation. It remains largely unknown wh…
ISEF · 2020
Translational Medical Science
Currently, there is a growing demand for organ transplants and an inability to meet such demand. Policies put in place by the United Network for Organ Sharing, or UNOS, restrict the acceptan…
ISEF · 2020
Translational Medical Science
Approximately every 3 minutes one person in the United States is diagnosed with a blood cancer. Leukemia is the most common cancer in children and teens, accounting for more than 3,500 cases…
ISEF · 2020
Translational Medical Science
Although Parkinson’s Disease (PD) is the fastest-growing leading cause of disability, 25% of patients are either misdiagnosed or diagnosed after severe neurodegeneration has already occurred…
ISEF · 2020
Biomedical and Health Sciences
Epilepsy is a terrible disease characterized by spontaneous recurrent seizures that negatively impact the day to day lives of affected patients. In addition to seizures, epilepsy patients al…
ISEF · 2020
Biomedical and Health Sciences
Familial Alzheimer’s Disease (FAD) is a hereditary neurodegenerative disease in which patients experience neurodegeneration and symptoms such as worsened memory, trouble learning, and motor…
ISEF · 2020
Biomedical and Health Sciences
The tumor suppressor protein p53, also known as the “guardian of the genome,” is known for its various protective functions in the cell ranging from cell cycle regulation to apoptosis. The p…
ISEF · 2020
Biomedical and Health Sciences
Our project investigates one method of decellularization, and it’s effectiveness on spinach leaves. We aim to strip spinach leaves of their DNA, and leave only the extracellular matrix (EMC)…
ISEF · 2020
Translational Medical Science
Overexpression of HER2 is present in about 20-30% of breast cancer tumors. HER2 sends growth signals from the cell membrane to the nucleus and contributes to the accelerated proliferation of…
ISEF · 2020
Biomedical and Health Sciences
Triple negative breast cancer (TNBC) has a higher mitotic index compared to other types of breast cancer yet Ki-67 values are still being used, despite an unclear mechanism. Here we found th…
ISEF · 2020
Biomedical and Health Sciences
As industry processed food becomes increasingly detrimental to human health, studies indicate that the heart and associated cardiovascular tissues deteriorate more rapidly. A significant cor…
ISEF · 2020
Translational Medical Science
Danio rerio embryos have been identified to have over eighty-two percent of genes similar to mammals and have recently been used as models for human embryos. This investigation exposed Danio…
ISEF · 2020
Translational Medical Science
Objective: Alzheimer’s Disease (AD) is a neurodegenerative disease with confirmation only from post-mortem autopsy. This study was done to aid diagnosis for the expected 14-million future pa…
ISEF · 2020
Translational Medical Science
Dopamine is a neurotransmitter that is responsible for reward, pleasure, and many other functions in humans. Major Depressive Disorder (MDD) causes persistent psychiatric and physical sympto…
ISEF · 2020
Biomedical and Health Sciences
Lung cancer is the leading cause of cancer death worldwide. Diagnostic methods including CT-scans are expensive and time-consuming. miRNAs participate in gene-silencing, and can be dysregula…
ISEF · 2020
Biomedical and Health Sciences
Tissue engineering is a research field for regenerating damaged biological tissue by substituting human cells on an appropriate scaffolds, one of them collagen as a biodegradable polymer has…
ISEF · 2020
Translational Medical Science
Venous thromboembolism, comprising of deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs approximately in 1 out of every 1000 American individuals. About two-thirds of episodes m…