ISEF · 2021
Mask Up
Biomedical and Health Sciences
Covid-19 has caused approximately 2,885,401 recorded deaths across the globe. Governments across the globe have installed mask mandates in order to slow the spread of this virus. This projec…
Discover science fair projects.
Browse real student projects, abstracts, and awards.
ISEF · 2021
Mechanisms Responsible for the Greater Therapeutic Efficacy of Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension in Mice with Heart Failure Caused by Myocardial Infarction
Translational Medical Science Second Award
Cardiac mesenchymal cells (CMCs) are novel, promising stem cells that improve heart function in rodents after myocardial infarction (MI) and may soon be used in clinical trials. Stem cells a…
ISEF · 2021
Minimizing Surface-Initiated Thrombogenesis in COVID-19 Patients Using the Fibronectin-Derived Peptide P12
Translational Medical Science
Vascular occlusion is a well-documented phenomenon known to be associated with cases of COVID-19 infection. Recent work establishes that vascular occlusion is related to fibrin(ogen) aggrega…
ISEF · 2021
Mitigating Digestive-related Obstructions and Other Risks Caused by Hard Particles of Stuffed Toys Through Creating a Coated Beeswax
Biomedical and Health Sciences
Stuffed toys have always been an integral part of most childhoods. The resulting global market for them is currently ~8 billion USD per year. Hard parts are included in stuffed toys to serve…
ISEF · 2021
Mom Care
Translational Medical Science
Approximately about 219 pregnant women die daily from disease complications due to their lack of awareness. So, awareness about health care for pregnant ladies has a very big concern in the…
ISEF · 2021
NIRS: An Innovative Approach to the Diagnosis of Neonatal Seizures
Biomedical and Health Sciences
Problem: Infant mortality and early disability. Objective: To assess the informativeness of NIRS in the early diagnosis of neonatal seizures. Methods. The study involved 60 newborns with hyp…
ISEF · 2021
Novel Stage Optimized Image Processing to Improve Deep Learning Driven Diagnosis of Early Stage Diabetic Retinopathy
Biomedical and Health Sciences Second Award
Diabetic retinopathy (DR) is the leading cause for blindness in the U.S. Current research on artificial intelligence based DR diagnosis shows promise but still has room for improvement befor…
ISEF · 2021
OCULI: Smartphone-based Screening Application and Low-Cost Lens that Identifies the Risk for Cataracts
Translational Medical Science
Problem Statement: Cataract is the leading cause of blindness according to the latest assessment by the World Health Organization (WHO). Majority of cases are from third-world countries wher…
ISEF · 2021
PANDwriting: An Accessible Parkinson's and Alzheimer's Novel Diagnostic Framework Using Vision-Based Handwriting Kinematic Analysis and Machine Learning
Translational Medical Science Second Award
PANDwriting is a novel system for diagnostic assessment of neurodegenerative diseases (NDs) using handwriting kinematic analysis, particularly targeted to increase Alzheimer's Disease (AD) a…
ISEF · 2021
Phase II: Predicting Early Onset Alzheimer's with Wearable Technology
Translational Medical Science
Alzheimer's Disease (AD), the sixth leading cause of death in the United States, is estimated to affect 13.8 million American seniors by 2050 (alz.org). A growing body of evidence indicates…
ISEF · 2021
Phenotypic Behavioral Expression of Different Genetic Lines of Drosophila melanogaster as Measured by the Negative Geotaxis Assay & Their Response to Lithium Chloride: A Pharmacogenomics Study
Biomedical and Health Sciences Fourth Award
Annually, adverse drug reactions cause 1.5 million hospitalizations. In practice, medicine is often prescribed by trial and error to determine the best drug and dosage. Genotypes influence t…
ISEF · 2021
Photobiomodulation by High Power Pulsed Nd:YAG Laser as a Novel Approach for the Treatment of Colorectal Cancer
Translational Medical Science
Colorectal (CRC) is a common malignancy, with an annual estimated incidence of 1.8 million newly diagnosed cases and 880,000 deaths globally. Currently, there is a low response rate to 5-Flu…
ISEF · 2021
Plectra Gold: Herbal Honey Formulation as an Effective Relief for Common Respiratory Diseases such as Flu, Cough and Sore Throat
Translational Medical Science
Plectra Gold is a herbal honey formulation that acts as an effective remedy for common respiratory problems such as flu, cough and sore throat. The main component of Plectra Gold is raw Tual…
ISEF · 2021
Postpartum Cup: A Lifesaving Innovation for Realtime and Accurate Estimation of Obstetric Blood Loss in Postpartum Haemorrhage
Biomedical and Health Sciences
Postpartum haemorrhage is the leading cause of maternal mortality worldwide. 1, 22,500 women bleed to death after childbirth every year. Blood loss is estimated by grossly inaccurate, visual…
ISEF · 2021
Prolonged Opioid Use After Surgery
Biomedical and Health Sciences
Prolonged opioid use after surgery causes substnce abuse and opioid use disorders. Physicans are prescribing opioids at high dosages and for longer durations of time than reccommended amount…
ISEF · 2021
ProteCount: An AI-Based Reader for Rapid Protein Quantification
Translational Medical Science
Blood testing for target protein concentrations remains the number one way to diagnose and monitor chronic diseases like arthritis, heart failure, and thyroid-related conditions. However, bl…
ISEF · 2021
Rapid, Noninvasive, Fluorescence-Based Detection for Elevated Levels of Nitric Oxide in Exhaled Breath, as a Marker for Hazardous PM2.5 Exposure
Translational Medical Science Fourth Award
There is a clear correlation between prolonged exposure to ambient fine particulate matter (PM2.5) and development of lethal disease. Today, there exists no personalized, quantifiable measur…
ISEF · 2021
Rapid Osteoporosis Risk Assessment: Non-invasive Detection Kit of Calcium, Phosphate and pH in Human Sweat
Biomedical and Health Sciences Fourth Award
Osteoporosis is a hard-to-detect disease involving bone degeneration. Most of the people living with osteoporosis are unaware of it until complications occur. Detection of calcium and phosph…
ISEF · 2021
Regeneration Rates of Dugesia japonica Using Glucose Oxidase Enhanced Honey
Biomedical and Health Sciences
The purpose of this investigation is to determine the effects of glucose oxidase enzyme enhanced honey as a topical wound healing accelerator. The antibiotic treatment will be applied to bis…
ISEF · 2021
Schwann Cell Support as a Novel Approach to Peripheral Nervous System Demyelinating Disease: A Phase Two Study
Biomedical and Health Sciences Third Award
Peripheral nervous system (PNS) demyelinating diseases, such as Guillain-Barré syndrome, are characterized by nerve impulse conduction anomalies. These anomalies can be caused by demyelinati…
ISEF · 2021
Single-cell Atlas of Mouse Colitis Tissue
Biomedical and Health Sciences
Colitis is a disease characterized by inflammation and epithelium injury in the colon. Colitis tissue consists of a variety of cells interacting with each other and gut microorganisms. These…
ISEF · 2021
Sputum-Based mRNA-Targeting Probes in Lung Cancer: A Noninvasive Early Diagnostic Tool
Translational Medical Science
Lung cancer, the leading cause of cancer death, has no simple, non-invasive early detection tests. This project aims to create a multiplex sputum-based RNA probe through the targeting of the…
ISEF · 2021
TeleAEye: Low-Cost Automated Eye Disease Diagnosis Using a Novel Smartphone Fundus Camera With AI
Translational Medical Science First Award
One billion people are blind or visually impaired due to a lack of access to eye care. The World Health Organization has established early detection as a key factor in the prevention and tre…
ISEF · 2021
Testing Fabric and Mask Particle Filtration Efficacy
Biomedical and Health Sciences
Since the rise of the SARS-CoV-2 pandemic, face masks have been widely accredited with decreasing the transmission of aerosol and respiratory droplets and slowing the spread of the virus. Th…
ISEF · 2021
Testing the Use of Phage Andhra at Five pH Levels to Treat Skin Infections Caused by Three Strains of the Bacteria Staphylococcus epidermidis and Identifying Strains with the CRISPR-Cas9 System
Translational Medical Science
Antibiotics are a great way to treat infections caused by bacteria. However, bacteria are evolving to become more resistant to antibiotics. Because of this, new treatments must be found. One…
ISEF · 2021
The Bacteria Between Us: The Connection Between Classrooms, Ventilation, and Airborne Bacteria
Biomedical and Health Sciences
The purpose for this experiment was to prove or disprove whether social distancing via classrooms at school is effective with HVAC units in mind. We hypothesized that if petri dishes are pla…
ISEF · 2021
The cGAS-STING Pathway in Rhabdomyosarcoma and Osteosarcoma
Translational Medical Science Third Award
Annually, about 15,000 people in the US are diagnosed with sarcoma. Rhabdomyosarcoma (RMS) and osteosarcoma (OS) are the most common sarcomas in children and adolescent young adults. Surviva…
ISEF · 2021
The Creation of Manganese (IV) Oxide Nanosheets as a Inexpensive and Effective Method of Measuring Blood Glucose
Biomedical and Health Sciences Fourth Award
Diabetes is an international health crisis. There is an extreme need for adequate testing methods. This led us to ask the question: Can we use manganese (IV) oxide nanosheets to create an in…
ISEF · 2021
The Effect of Ayurvedic Plant Extracts -- Mucuna pruriens and Brassica oleracea -- on the Alleviation of Motor Symptoms in PINK1 Drosophila melanogaster: A Model of Parkinson's Disease
Biomedical and Health Sciences
Parkinson’s Disease (PD) is a neurodegenerative disease that is characterized by loss of dopaminergic neurons of the substantia nigra, negatively affecting motor control and causing symptoms…
ISEF · 2021
The Effect of Deferoxamine and Ferrostatin-1 Treatments on Total ROS in HK-2 Cells
Biomedical and Health Sciences Third Award
Investigations indicate that diabetic patients with myocardial infarctions (MI) have an increased risk of acute kidney injury (AKI) post-MI. In diabetic MI, blood hemoglobin (Hb) rises, whic…