Browse real student projects, abstracts, and awards.
ISEF · 2026
Biomedical and Health Sciences
Nerve degeneration causes devastating symptoms for millions of patients worldwide. While some peripheral nerves experience recovery, others experience chronic neuropathic pain due to sensory…
ISEF · 2026
Biomedical and Health Sciences
Impaired wound healing is a widespread complication experienced by diabetic patients, with persistent hyperglycemic conditions being a central factor that disrupts cellular repair programs.…
ISEF · 2026
Biomedical and Health Sciences
Obesity increased the occurrence of diabetes in America, leading many to seek “healthier” alternatives and use of sweeteners. This project determined how sugar and different artificial sweet…
ISEF · 2026
Biomedical and Health Sciences
Extracellular Vesicles (EVs) are tiny particles containing biomaterials that have been noted for their regenerative capabilities and potential, especially for treating neurodegenerative dise…
ISEF · 2026
Biomedical and Health Sciences
Purpose: Current anti-cancer adoptive cell immunotherapies have three major hurdles: extraction and preservation of autologous cells; engineering, expansion, and activation of cells ex vivo;…
ISEF · 2026
Biomedical and Health Sciences
Tumor growth in lung adenocarcinoma (LUAD) – the most prevalent form of lung cancer, with a 5-year survival rate below 20% – is promoted by abnormal vasculature. Importantly, the mechanisms…
ISEF · 2026
Biomedical and Health Sciences
Radiation therapy is a cornerstone of cancer treatment, but radiation-induced skin injury remains a significant clinical challenge. This study aims for precise, controlled irradiation with a…
ISEF · 2026
Translational Medical Science
Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers and can develop resistance to current therapies. This creates an urgent need for more effective and targeted treatment…
ISEF · 2026
Biomedical and Health Sciences
T-cell malignancies are aggressive hematologic cancers with limited targeted treatment options and high relapse rates. These malignancies are characterized by the overexpression of the PD-1…
ISEF · 2026
Biomedical and Health Sciences
In trauma and mass casualty events, hemorrhage remains a leading cause of preventable death as definitive car is often delayed by limited access to safe, compatible donor blood. Deployment o…
ISEF · 2026
Translational Medical Science
Oral cancer therapeutics often fail due to drug degradation within the gastrointestinal tract before systemic absorption. This study evaluated the gastrointestinal stability of a carbon nano…
ISEF · 2026
Translational Medical Science
Elevated atmospheric CO2 (atmCO2) is a persistent operational challenge in human spaceflight, where crew exhalation and limited ventilation lead to CO2 accumulation within the cabin. As a re…
ISEF · 2026
Biomedical and Health Sciences
Glioblastoma multiforme (GBM) remains the most aggressive primary brain tumor, with a median survival of 12–15 months despite multimodal therapy. Identifying compounds that selectively induc…
ISEF · 2026
Biomedical and Health Sciences
Fragrance products have been on the rise in popularity recently. Volatile organic compounds (VOCs), which are toxic airborne chemicals, have shown to be most prominent in the product's ingre…
ISEF · 2026
Biomedical and Health Sciences
Three-dimensional (3D) cell culture is an emerging technique that allows cells to grow in a way that more closely resembles how they exist in the body. Unlike traditional two-dimensional (2D…
ISEF · 2026
Biomedical and Health Sciences
Triple negative breast cancer is notoriously difficult to treat bacause it lacks estrogen receptors, progesterone receptors, and HER2 protein that drive the majority of breast cancers and th…
ISEF · 2026
Translational Medical Science
Lung cancer remains one of the leading causes of death worldwide. In 2026 in the United States, an estimated 124,990 people are expected to die from this disease. In Hawai?i, the situation i…
ISEF · 2026
Translational Medical Science
Every year, 795,000 people die or suffer permanent disability — not from untreatable disease, but from a missed diagnosis. A patient takes a common painkiller alongside a daily prescription,…
ISEF · 2026
Biomedical and Health Sciences
Organophosphate (OP) exposure affects millions worldwide due to life-threatening and possibly irreversible symptoms. Neurological injury often persists after treatment, suggesting non-cholin…
ISEF · 2026
Translational Medical Science
Translational research on neurodegenerative diseases is constrained by the cost, long timelines, and variability of generating mature neuronal assay substrates, which also limits scalable pr…
ISEF · 2026
Biomedical and Health Sciences
Psychiatric disorders, including schizophrenia (SCZ) and bipolar disorder (BD), are leading causes of global disability. The development of effective therapeutics is challenged by the comple…
ISEF · 2026
Translational Medical Science
In rural areas of the world, such as villages in India & Africa, inhabitants lack access to medical infrastructure. Due to this, early disease diagnosis is not possible, as early symptoms fo…
ISEF · 2026
Biomedical and Health Sciences
Extracorporeal Membrane Oxygenation (ECMO) is a life-saving cardiopulmonary support system for patients with severe cardiac and/or respiratory failure. Its use has increased substantially si…
ISEF · 2026
Translational Medical Science
Pancreatic ductal adenocarcinoma (PDAC) ranks 10th in US cancer incidence, yet it causes more deaths per year than breast cancer, ranked 1st, a disparity largely driven by complications rega…
ISEF · 2026
Translational Medical Science
Background: Treatment of Multiple Myeloma (MM) with bispecific antibodies (bsAb) results in an increased risk of infection, and predicting this risk is a significant unmet need. Aim: Develop…
ISEF · 2026
Translational Medical Science
Abstract Parkinson's disease often affects voice and speech years before motor symptoms become clinically evident, and clinical diagnosis can take years to confirm. Machine learning applied…
ISEF · 2026
Translational Medical Science
The purpose of this investigation was to develop a machine learning model capable of predicting early vocal patterns associated with glottic carcinoma risk using acoustic biomarkers and life…
ISEF · 2026
Translational Medical Science
Triple-negative breast cancer (TNBC) is one of the deadliest breast cancer subtypes because it lacks the receptors targeted by most therapies, leaving patients with few treatment options. Th…
ISEF · 2026
Translational Medical Science
Diagnosing drug-resistant strains Mycobacterium tuberculosis (Mtb) is critical for informing treatment plans and limiting infections. However, existing diagnostics are slow and cover a narro…
ISEF · 2026
Biomedical and Health Sciences
Chemoresistance remains a primary cause of cancer treatment failure and is increasingly attributed to non-genetic regulatory mechanisms. Emerging evidence suggests that three-dimensional chr…