Browse real student projects, abstracts, and awards.
ISEF · 2026
Translational Medical Science
Breast cancer progression is influenced by estrogen receptor signaling and tumor angiogenesis, yet the biological association between these pathways remains incompletely understood. The purp…
ISEF · 2026
Biomedical and Health Sciences
Per- and polyfluoroalkyl substances (PFAS) are highly persistent fluorinated chemicals used in many consumer and industrial products that are prone to bioaccumulation due to strong C-F bonds…
ISEF · 2026
Translational Medical Science
Medulloblastoma is the most prevalent malignant brain tumor in children, and 75% of children that have it are under the age of ten. However, its current treatments are surgery, chemotherapy,…
ISEF · 2026
Translational Medical Science
Creutzfeldt-Jakob Disease (CJD) is a deadly neurodegenerative disease caused by prion proteins (PrPSC), which trigger normal cellular proteins to misfold, resulting in aggregation and neuron…
ISEF · 2026
Translational Medical Science
Dry eye disease (DED) is increasingly understood as a disorder involving both ocular surface inflammation and corneal nerve damage. Although platelet-rich plasma (PRP) and cenegermin (Oxerva…
ISEF · 2026
Biomedical and Health Sciences
COVID-19 infection causes disordered sugar metabolism, both in acute infection and long COVID. Diabetic COVID-19 patients with hyperglycemia have higher mortality rates, and infection elevat…
ISEF · 2026
Translational Medical Science
GLP-1 receptor agonists are widely used to treat diabetes and obesity and are being investigated for potential cognitive benefits in Alzheimer's disease. However, these treatments simultaneo…
ISEF · 2026
Biomedical and Health Sciences
Each year, about 58,500 Americans are diagnosed with oral or oropharyngeal cancer, and over 12,000 of them will not survive it. When oral cancer is caught at a localized stage, the 5-year su…
ISEF · 2026
Biomedical and Health Sciences
Women are often medicated according to the male body. Throughout history, women have been underrepresented in clinical trials within medical research, and drugs have been developed based on…
ISEF · 2026
Biomedical and Health Sciences
Leukemia remains a leading cause of global cancer mortality, with Acute Myeloid Leukemia (AML) presenting the most aggressive clinical profile with frequent relapse even after treatment. Ove…
ISEF · 2026
Translational Medical Science
Inflammatory bowel disease (IBD), which encompasses Crohn's disease and ulcerative colitis, affects about 5 million people worldwide and is caused by the inflammation of the gastrointestinal…
ISEF · 2026
Translational Medical Science
Background: Skin aging is a natural biological process that was cause by a comprehensive combination of intrinsic and extrinsic factors. This process varies a lot among individuals and often…
ISEF · 2026
Translational Medical Science
Every 3 seconds, a new case of dementia is diagnosed worldwide, and more than 55 million people live with dementia, underscoring the need for innovative, accessible complementary strategies…
ISEF · 2026
Translational Medical Science
The prevalence of Alzheimer's disease (AD), a multifactorial, neurodegenerative disease characterized by a decline in cognitive functions, is projected to double by 2060, underscoring a grow…
ISEF · 2026
Biomedical and Health Sciences
Traumatic brain injuries (TBIs) are a major public health concern within the United States alone, with approximately 2.5 million cases reportedly annually (CNS, 2021). TBIs contribute to sig…
ISEF · 2026
Translational Medical Science
Pressure ulcers affect 2.5+ million people annually in the U.S., contributing to 60,000+ deaths and $26+ billion in healthcare costs. Current prevention methods remain inadequate. Preventive…
ISEF · 2026
Translational Medical Science
Prior research has indicated that the synthetic peptide D-(KLAKLAK)2 and its analogues exhibit potent cancer toxicity (oncotoxicity) and pro-apoptotic activity when internalized within mamma…
ISEF · 2026
Biomedical and Health Sciences
The purpose of this study was to explore the efficacy of three between-inning recovery methods [Active recovery (AR), passive recovery (PR), and electromuscular stimulation (EMS)] among high…
ISEF · 2026
Translational Medical Science
Strokes are a leading cause of disability and death in adults in the US and globally. Approximately 40% of stroke survivors develop aphasia, an acquired language and communication disorder t…
ISEF · 2026
Biomedical and Health Sciences
Mutations in the FLT3 receptor, present in approximately one third of patients with acute myeloid leukemia (AML), are associated with an aggressive course of the disease, a high risk of rela…
ISEF · 2026
Biomedical and Health Sciences
Immune thrombocytopenia (ITP), a life-threatening disorder of humans and dogs, leads to spontaneous bleeding from antibody-mediated platelet destruction. Standard immunosuppressive therapies…
ISEF · 2026
Translational Medical Science
Around 40% of the world's population (approximately 3.3 billion people) are at risk of developing cancer at some point in their lives. TP53 (Tumor Protein 53) is a gene altered in most human…
ISEF · 2026
Biomedical and Health Sciences
Alzheimer’s disease is a neurodegenerative disorder strongly tied to Amyloid-ß aggregation, leading to cellular dysfunction and an inhibition of movement. In the Caenorhabditis elegans CL200…
ISEF · 2026
Translational Medical Science
Background: Optimizing performance and enhancing resilience among military personnel who are frequently exposed to traumatic situations is challenging. Outstanding physical fitness, the foun…
ISEF · 2026
Translational Medical Science
Introduction: Endometrial Cancer (EC), the most common and deadliest gynecological cancer in the U.S., has seen a steady rise in incidence and mortality since 2003 across all races. When ide…
ISEF · 2026
Biomedical and Health Sciences
Lactase dietary supplements are widely used to address lactose intolerance, a condition where the small intestine produces insufficient lactase enzyme to break down lactose, the natural suga…
ISEF · 2026
Translational Medical Science
Triple-negative breast cancer (TNBC) remains a clinical challenge due to its aggressive nature and the lack of targeted therapies. Traf2 and NCK-interacting kinase (TNIK), a key regulator of…
ISEF · 2026
Biomedical and Health Sciences
Human Immunodeficiency Virus (HIV) infection is associated with neurocognitive dysfunction (NeuroHIV), which can occur in 30–50% of people with HIV, despite successful combination antiretrov…
ISEF · 2026
Translational Medical Science
Meniscus injuries are among the most common orthopedic conditions, with approximately 1 million surgeries annually. Injuries in the avascular zone cannot self-regenerate, and modern scaffold…
ISEF · 2026
Biomedical and Health Sciences
Parkinson's disease is a progressive neurodegenerative disorder requiring early intervention, yet screening is often delayed due to a dependency on expensive, in-person clinical assessments.…