Browse real student projects, abstracts, and awards.
ISEF · 2025
Translational Medical Science
Histone Lysine Demethylase 4 (KDM4) and Mammalian Bromodomain and Extra-Terminal Domain (BET) are proteins that are highly dysregulated in multiple kinds of cancers. This study researched th…
ISEF · 2025
Biomedical and Health Sciences
Cancer has remained the leading cause of death globally, with the mutation of the Tumor Suppressor Gene TP53 via DNMT1 methylation occurring in 50% of cases. Current epigenetic therapies mis…
ISEF · 2025
Biomedical and Health Sciences
Pulmonary hypertension (PH) is a pulmonary vascular disease exhibiting a high mean arterial pressure (25mmHg at rest). Cellular hyperproliferation contributes to vascular remodeling, leading…
ISEF · 2025
Biomedical and Health Sciences
Short-read RNA sequencing is limited by its inability to fully sequence long genetic transcripts, requiring computational reconstruction that often hinders accurate characterization of trans…
ISEF · 2025
Translational Medical Science
Background: Pancreatic Ductal Adenocarcinoma (PDAC) is the most common form of pancreatic cancer, a cancer with only a 12%-five-year survival rate. PDAC relies on the Human antigen RNA bindi…
ISEF · 2025
Translational Medical Science
Cancer is currently the second leading cause of death in the world. There are several treatments available, but most have side effects or are highly expensive. Therefore, it is necessary to…
ISEF · 2025
Biomedical and Health Sciences
Nicotine is a highly addictive drug that has been found to disrupt gamma aminobutyric acid (GABA) neuron migration in the developing cerebral cortex. This project investigates if GABA neuron…
ISEF · 2025
Translational Medical Science
Leukemia, a cancer of blood-forming tissues, is the 10th most common cancer. This study focused on the impact that cannabinoids (CBD) and nicotine had on the growth rate of K562 cell lines.…
ISEF · 2025
Biomedical and Health Sciences
Sleep is a critical physiological process necessary for cognitive function, emotional stability, and brain health. However, both acute and chronic sleep deprivation significantly impair brai…
ISEF · 2025
Biomedical and Health Sciences
Pediatric sarcomas comprise approximately 10% of childhood solid tumors, with metastatic disease yielding survival rates as low as 20-25%. Despite many efforts, advancements in survival outc…
ISEF · 2025
Translational Medical Science
Background: Parkinson’s disease (PD) is a neurodegenerative disease caused by degeneration of dopaminergic neurons due to alpha-synuclein (AS) aggregation. Microbiome dysbiosis has been reco…
ISEF · 2025
Biomedical and Health Sciences
This study aims to understand how the increase in pH levels within the stomach, caused by a condition called Hypochlorhydria, contribute to a decrease in the ability to digest food and absor…
ISEF · 2025
Biomedical and Health Sciences
The use of antibiotics to inhibit breast cancer cell proliferation is a novel approach to cancer treatment. Antibiotics, such as gentamicin and chloramphenicol, primarily known for their ant…
ISEF · 2025
Biomedical and Health Sciences
The purpose of this project was to determine if increased hypohydration of a sheep brain is directly correlated with brain tissue damage after exposure to a concussion-inducing force. The hy…
ISEF · 2025
Translational Medical Science
Multiple Myeloma is a type of hematologic cancer that often significantly affects people's lives; therefore, this scientific research was created with the objective of studying the relations…
ISEF · 2025
Biomedical and Health Sciences
Gastric adenocarcinoma is the fourth most common type of cancer in Brazil, often diagnosed at advanced stages, when the cure rate drops to 30%. MicroRNAs (miRNAs) are essential post-transcri…
ISEF · 2025
Biomedical and Health Sciences
Bacterial cellulose (BC) is a promising biomaterial for wound healing and regenerative medicine due to its biocompatibility, water retention, and high tensile strength. This study evaluates…
ISEF · 2025
Biomedical and Health Sciences
Iron-sulfur (Fe-S) clusters are cell-essential cofactors present in roughly 60 proteins, including DNA polymerases, subunits of oxidative phosphorylation complexes, and iron-sensing proteins…
ISEF · 2025
Biomedical and Health Sciences
Hypermobile Ehlers-Danlos Syndrome (hEDS) is an inherited connective tissue disorder that primarily stems from defects in the extracellular matrix, namely collagen. Within those diagnosed, f…
ISEF · 2025
Biomedical and Health Sciences
Age-related macular degeneration, or AMD, is a progressive degeneration of the retina that causes significant central visual impairment, impacting nearly 20 million elderly adults in the Uni…
ISEF · 2025
Biomedical and Health Sciences
Duchenne Muscular Dystrophy (DMD) is a severe genetic condition that causes progressive muscle weakness and degeneration. Despite current treatments focusing on symptom management, no cure e…
ISEF · 2025
Translational Medical Science
Despite the fact that studies have established a notable link between tourism-particularly cruise ship traffic-and increased respiratory illnesses, there is a lack of official research exami…
ISEF · 2025
Translational Medical Science
Thyroid cancer (TC) is one of the most common endocrine malignancies worldwide, with 821,214 newly diagnosed cases in 2022. It has the fastest growth rate across all cancers. Despite its pre…
ISEF · 2025
Biomedical and Health Sciences
Congenital heart defects (CHDs) refer to structural defects in the heart that are present at birth. Hypoplastic Left Heart Syndrome (HLHS) is the most complex CHD and occurs when the left si…
ISEF · 2025
Translational Medical Science
Rheumatoid Arthritis (RA) is an autoimmune arthropathy that affects over 18 million people globally, causing immense joint pain and swelling. Current treatments (e.g., methotrexate, adalimum…
ISEF · 2025
Biomedical and Health Sciences
Inflammation is the body's natural response to combat infections, allergies, or injuries. The most commonly available treatments—non-steroidal anti-inflammatory drugs (NSAIDs) and corticoste…
ISEF · 2025
Translational Medical Science
Commonly known as the yellow water lily root or kaandoosh in Ojibwe language, the rhizome of Nuphar advena is utilized by Indigenous communities for treating a wide variety of ailments, incl…
ISEF · 2025
Translational Medical Science
Stroke, the fifth leading cause of death and a major cause of disability in the US, is a time-critical emergency handled by EMS agencies—20% of which manage 80% of service calls (Krohmer & E…
ISEF · 2025
Translational Medical Science
Diabetic macular edema (DME) is a leading cause of vision impairment, affecting up to 30% of diabetics. It results from retinal fluid buildup due to vascular leakage and is commonly treated…
ISEF · 2025
Biomedical and Health Sciences
Duchenne Muscular Dystrophy (DMD) is an inherited X-linked disease with an incidence of 1:3,600. Patients become weak at 2-3 years old with progression to respiratory failure and death in th…