Browse real student projects, abstracts, and awards.
ISEF · 2026
Translational Medical Science
Breast cancer is the leading cause of cancer-related death among women, with approximately 42,000 deaths annually in the United States and over 700,000 worldwide. Brain metastases represent…
ISEF · 2026
Translational Medical Science
Neurodegenerative diseases like Alzheimer's affect millions worldwide, yet current diagnostic methods remain invasive, expensive, and largely inaccessible during the critical early intervent…
ISEF · 2026
Translational Medical Science
Helicobacter pylori infects over 4.4 billion people and is a WHO Group 1 carcinogen linked to gastric cancer. Rising antibiotic resistance, particularly to clarithromycin (>30% in many regio…
ISEF · 2026
Translational Medical Science
Drug repurposing involves identifying new therapeutic uses for existing drugs that have already been approved or tested for other diseases, offering a faster and lower-cost alternative to tr…
ISEF · 2026
Biomedical and Health Sciences
Protamine 1 (PRM1) and protamine 2 (PRM2) are essential for packaging sperm DNA and maintaining genome stability during spermatogenesis. Changes in their expression levels are associated wit…
ISEF · 2026
Translational Medical Science
Neurodegenerative diseases, including Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI), are typically diagnosed after 50-80% neuronal loss, reflecting a critical failure of early…
ISEF · 2026
Translational Medical Science
Visual impairment (VI) affects 2.2 billion people worldwide, and 1 billion cases are preventable with early diagnosis. Retinal diseases are preventable causes of VI. Clinical Decision Suppor…
ISEF · 2026
Biomedical and Health Sciences
Despite advances in immunotherapy, up to 60% of melanoma patients do not respond to treatment. Emerging evidence suggests that physical exercise enhances anti-tumor immunity; however, the mo…
ISEF · 2026
Translational Medical Science
Purpose: About 7.2 million Americans are living with Alzheimer's Disease (AD), with the number expected to to double by 2060. Currently used drugs for AD only reduce disease symptoms and mar…
ISEF · 2026
Biomedical and Health Sciences
This project is a three year study in investigating possible advancements that could made in the medical world. I created 3D printed casts and did comparative testing with different, more mo…
ISEF · 2026
Translational Medical Science
Pancreatic cancer is one of the deadliest cancers in the world, largely due to late-stage diagnosis. Current imaging diagnostic tools like CT and MRI scans lack the accuracy and sensitivity…
ISEF · 2026
Biomedical and Health Sciences
Dehydration is one of the leading causes of hospital admissions. Evaluations to measure hydration status in clinical settings utilize methods such as blood tests, urinalysis, and skin turgor…
ISEF · 2026
Translational Medical Science
Airborne Neurotropic Viruses (ANVs) are emergent invasive neuropathogens, affecting 300-500 million people and being responsible for >700,000 deaths annually. Early neurotropic transcriptomi…
ISEF · 2026
Biomedical and Health Sciences
Diabetes mellitus is a metabolic disorder resulting in the dysregulation of blood glucose (BG), affecting more than 14% of adults. BG is typically regulated by the pancreatic hormone insulin…
ISEF · 2026
Translational Medical Science
Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease associated with the deterioration of motor control and cognitive function as age advances. Representing the fa…
ISEF · 2026
Biomedical and Health Sciences
Over 400 million people lack access to basic healthcare globally, with physician-to-patient ratios below 1 per 10,000 in low-resource regions. Language barriers, limited diagnostic infrastru…
ISEF · 2026
Translational Medical Science
Esophageal obstruction caused by cancer and benign strictures can severely impair swallowing, leading to poor nutrition and reduced quality of life. Although conventional stents are commonly…
ISEF · 2026
Translational Medical Science
Age-related macular degeneration (AMD) is a neurodegenerative eye disease that impacts roughly 200 million people worldwide. It occurs in the macula, which contains a dense number of photore…
ISEF · 2026
Biomedical and Health Sciences
Cancer progression is driven by immune tolerance, insufficient co-stimulation, and impaired danger signaling within the tumor microenvironment, limiting anti-tumor immunity. This study prese…
ISEF · 2026
Translational Medical Science
EquiliMind is a multimodal fall-prevention system designed to address the unpredictable vertigo, imbalance, and sudden fall risk associated with Ménière’s disease. Current clinical approache…
ISEF · 2026
Translational Medical Science
Alzheimer's disease disproportionately affects Latinx communities, yet most prediction models rely on neuroimaging biomarkers that are costly and inaccessible to underserved populations. Thi…
ISEF · 2026
Biomedical and Health Sciences
Overexpression of BCL-2 and XIAP proteins inhibits caspase-mediated apoptosis in mutated cells, promoting survival and driving chemoresistance, leading to poor clinical prognosis, highlights…
ISEF · 2026
Translational Medical Science
Breast cancer, the most common cancer in women, is treated with chemotherapy drugs, a systemic treatment prone to multidrug and chemoresistance. An improved adjunctive treatment that increas…
ISEF · 2026
Translational Medical Science
The lack of rapid, accessible, and precise quantitative biomarkers for lesion grading remains the primary barrier to preventing cervical cancer—a leading cause of cancer death among women wo…
ISEF · 2026
Translational Medical Science
It is estimated that approximately 9.8% of the world's population suffers from acne, a dermatological condition that can have significant clinical and psychosocial impacts, compromising the…
ISEF · 2026
Biomedical and Health Sciences
Uncontrolled minor bleeding requires effective, safe, and accessible materials. However, most commercial hemostatic dressings rely on synthetic, non-renewable polymers and present high produ…
ISEF · 2026
Biomedical and Health Sciences
Eosinophilic Esophagitis (EoE) is a chronic, immune-mediated esophageal disorder that currently requires repeated invasive endoscopic biopsies for diagnosis and disease monitoring. The absen…
ISEF · 2026
Translational Medical Science
Introduction: Parkinson’s disease (PD) is characterized by the loss of dopamine producing neurons. Many pathways involving mitochondrial dysfunction and synaptic function are involved in thi…
ISEF · 2026
Translational Medical Science
Modern vaccines are effective but often depend on complex formulations containing depot-forming adjuvants and stabilizing excipients. Emerging approaches such as neoantigen cancer vaccines a…
ISEF · 2026
Biomedical and Health Sciences
Chronic cerebral hypoperfusion (CCH) seriously affects the well-being of the patient and has been proposed as a risk factor for cognitive impairment and dementia. While recent research has d…