Browse real student projects, abstracts, and awards.
ISEF · 2025
Cellular and Molecular Biology
Epigenetics is the study of how environmental stimuli affect gene expression without altering the DNA sequence. DNA methylation is an epigenetic mechanism in which a 5-methyl group binds to…
ISEF · 2025
Cellular and Molecular Biology
Sorafenib, a targeted anticancer therapy, is used in the treatment of advanced renal cell carcinoma by inhibiting vascular endothelial growth factor receptors (VEGFRs) and tyrosine kinases (…
ISEF · 2025
Cellular and Molecular Biology
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that persistently infects the central nervous system (CNS) of up to a third of the world’s population. In the immune compe…
ISEF · 2025
Cellular and Molecular Biology
Research showed significant changes in the brain of Drosophila melanogaster such as fewer stem cells and smaller brains after knocking out nhes in the brain. Nhes also affect a decline in ag…
ISEF · 2025
Cellular and Molecular Biology
The endothelium, a layer of cells lining the inner wall of coronary arteries, contributes to blood hemostasis and healthy function of the heart. In coronary artery disease (CAD), endothelial…
ISEF · 2025
Cellular and Molecular Biology
Epidemiological studies performed in large cohorts among different populations indicate a negative correlation between developing melanoma skin cancer and drinking coffee. While coffee’s pop…
ISEF · 2025
Cellular and Molecular Biology
Constituting up to 90% of tumor volume in pancreatic ductal adenocarcinoma (PDAC), fibrotic tissue growth (desmoplasia) acts to inhibit chemotherapeutic drug delivery through physical blocka…
ISEF · 2025
Cellular and Molecular Biology
Multiple myeloma (MM) is an incurable cancer of malignant plasma cells with a 5-year survival of 54%. Immunotherapy has recently emerged as a highly promising modality to treat MM. CD8+ T-ce…
ISEF · 2025
Cellular and Molecular Biology
Our project determined that resazurin, a synthetic fluorescing agent originally used as a bioburden detector, is a practical fluorescing agent for quantifying NADH in cell-free reactions. We…
ISEF · 2025
Cellular and Molecular Biology
Aedes aegypti is a mosquito species that transmit diseases, including dengue fever, Zika virus and chikungunya. The control of A. aegypti populations is essential to prevent the spread of th…
ISEF · 2025
Cellular and Molecular Biology
Genetics is an ever-expanding field of research. The genetic field has rapidly expanded from Mendel’s studies to genetically modified treatments, multi-allele variation knowledge, and studie…
ISEF · 2025
Cellular and Molecular Biology
Current underlying mechanisms to treat neurodegenerative diseases (ND) are limited due to an incomplete understanding. Tight junctions (TJ) and efflux pumps on the BBB restrict drug permeabi…
ISEF · 2025
Cellular and Molecular Biology
Native Hawaiian and Pacific Islander populations experience a high incidence of kidney disease, with 921 cases per million annually (Xiang et al., 2020). A key contributing factor is the hea…
ISEF · 2025
Cellular and Molecular Biology
Apoptosis is a key mechanism in many cancer therapies and can be induced through the interaction of death receptors with specific ligands. Among these, TNF-alpha and TRAIL are widely studied…
ISEF · 2025
Cellular and Molecular Biology
Alzheimer's disease (AD) pathogenesis follows a pattern of selective vulnerability, defined by varying levels of neurodegeneration across brain regions and neuronal populations. While the me…
ISEF · 2025
Cellular and Molecular Biology
Finding a treatment for breast cancer has been a persisting need as one in eight women will experience this disease in her lifetime. Current treatment options present harmful side effects an…
ISEF · 2025
Cellular and Molecular Biology
Manganese is a central promoter of malignancy in cancer. In the previous project, it was observed that Mn alters gene expression of metal transporters, favoring the accumulation of this elem…
ISEF · 2025
Cellular and Molecular Biology
The purpose of this experiment was to design a cell model using a rat pheochromocytoma (PC12) cell to simulate Diabetic Peripheral Neuropathy (DPN). It was proposed that the higher the level…
ISEF · 2025
Cellular and Molecular Biology
Approximately 5.9% of the global population—over 300 million people—suffer from rare genetic disorders, many of which require AAV-based gene therapy. AAV-B3, an ancestrally derived serotype…
ISEF · 2025
Cellular and Molecular Biology
Skeletal muscle cells regulate and provide many bodily functions. Skeletal muscle cells support movement, posture, and temperature regulation. In addition, skeletal muscle triggers an immune…
ISEF · 2025
Cellular and Molecular Biology
Hypoxia is common in solid tumors. Hypoxia Inducible Factor 1 Alpha (Hif1a) is upregulated and stabilized under hypoxic conditions, leading to tumor growth. This experiment targets Hif1a bec…
ISEF · 2025
Cellular and Molecular Biology
In 2022, 2.3 million cases of breast cancer were diagnosed worldwide, with approximately 17% classified as triple-negative breast cancer (TNBC). TNBC is challenging to treat due to the absen…
ISEF · 2025
Cellular and Molecular Biology
Toxic methylmercury (MeHg) readily crosses the blood brain and placental barriers, leading to developmental delays and neurological issues particularly with in utero exposure. Upon exposure,…
ISEF · 2025
Cellular and Molecular Biology
Mismatch repair (MMR) deficiency in DNA is an ongoing problem as a factor behind DNA mutations and various cancers, including colorectal cancer and gliomas. Understanding how to strengthen D…
ISEF · 2025
Cellular and Molecular Biology
Chromosomal rearrangements caused by mobile transposons (TEs) are implicated in human cancers and neurological disorders. The Ac element of the Ac(Activator)/Ds(Dissociation) TE system, foun…
ISEF · 2025
Cellular and Molecular Biology
Neurogenesis during early embryonic development is a highly regulated, transcriptional process that establishes the framework for the vertebrate central nervous system (CNS). The QSER1 gene…
ISEF · 2025
Cellular and Molecular Biology
In vitro drug sensitivity testing is critical for identifying effective cancer treatments. However, due to the vast number of potential drug monotherapies and combination therapies, in vitro…
ISEF · 2025
Cellular and Molecular Biology
Central nervous system (CNS) diseases such as Alzheimer's, epilepsy, and stroke affect over 1 billion people globally, and dysregulated astrocytic calcium signaling can drive these pathologi…
ISEF · 2025
Cellular and Molecular Biology
Introduction: Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest malignancies due to late diagnosis, extensive metastasis, and limited treatment options. A multifunctional g…
ISEF · 2025
Cellular and Molecular Biology
Alzheimer’s disease (AD), a neurodegenerative disorder causing cognitive deterioration, remains a leading cause of death. Previous research has not fully clarified the impact of amyloid-beta…