38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Malignant peripheral nerve sheath tumors (MPNSTs) are a rare and aggressive cancer that develops from nerve tissues, affecting about 1 in 100,000 people. These tumors are difficult to remove…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
The precise and effective evaluation of surgical recovery presents significant challenges in the medical field, and current methods for evaluating recovery can be invasive, subjective, and e…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Hemorrhage remains a leading cause of preventable death in trauma, battlefield injury, obstetric emergencies, and mass casualty events because definitive care is often delayed by limited acc…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division) Third Award
Eczema, or atopic dermatitis, affects 30% of children and 10% of adults in the United States (NIH). While corticosteroids suppress inflammation, they weaken the skin barrier, causing recurre…
ISEF · 2026
Cellular and Molecular Biology
The melanocortin-4 receptor (MC4R) is a G protein–coupled receptor that plays a critical role in energy homeostasis by activating cyclic adenosine monophosphate (cAMP) signaling to suppress…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Cancer combination therapy may enhance therapeutic efficacy by concurrently targeting multiple survival pathways; however, experimentally evaluating millions of potential drug pairs is neith…
ISEF · 2026
Cellular and Molecular Biology
Multiple myeloma (MM) is a hematologic malignancy characterized by the uncontrolled proliferation of malignant plasma cells in the bone marrow. This study explored the potential of Pristimer…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Since ultraviolet (UV) radiation from sunlight damages the DNA of living cells, protecting cells is important to lead a healthy life. One way cells could be protected is through the use of n…
ISEF · 2026
Cellular and Molecular Biology Fourth Award
Azole antifungals have served as frontline therapies for Candida infections. However, increasing azole-resistant Candida species presents a real clinical challenge requiring alternative anti…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Early cancer detection is commonly framed as a classification problem, yet such approaches rarely address whether early disease states are physically detectable in molecular data at all. Her…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division) Second Award
Rapid identification of respiratory pathogens is essential for selecting the appropriate treatment, especially in primary care clinics and developing areas with limited medical resources. I…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
The molecular mechanisms driving the transition from Idiopathic Pulmonary Fibrosis (IPF) to Lung Adenocarcinoma (LUAD) remain unresolved. Since 70% of IPF-associated tumors arise within exis…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Drug resistance remains a critical challenge in oncology, necessitating the identification of quantitative biomarkers for therapeutic evasion. This study investigated the extent to which Sha…
ISEF · 2026
Cellular and Molecular Biology First Award
Epilepsy affects over 50 million people, and one in three cannot stop their seizures with medication. Neuromodulatory therapies are the leading alternative, but development has been bottlene…
ISEF · 2026
Cellular and Molecular Biology
Modern nucleic acid sequencing enables rapid and cost-effective genomic analysis, but for low-input samples, amplification via polymerase chain reaction (PCR) remains a critical bottleneck.…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Background: Sertoli cells (SCs) play an important role in the development and function of the testes and in the process of spermatogenesis (generation of sperm). They are nurse cells, which…
ISEF · 2026
Cellular and Molecular Biology
Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the United States, with metastasis responsible for the majority of CRC deaths. Emerging research suggests that micro…
ISEF · 2026
Cellular and Molecular Biology Fourth Award
Ovarian cancer is the deadliest gynecological cancer, with a five year survival rate that still barely exceeds 50%. Mesenchymal stem cells (MSCs) are a stromal cell population in the tumor m…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Introduction Glioblastoma is a highly malignant brain tumor characterized by aggressive growth, frequent recurrence, and limited treatment options. Glioblastoma cells produce the S100A16 pro…
CSEF · 2026
Biochemistry/ Molecular Biology (Junior Division)
Globally, each year 20 million people are diagnosed with cancer. 61% of these people struggle with paying for expensive treatments like Neo-antigen therapies which cost $100,000, and CAR-T-c…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
Caffeine is commonly consumed in drinks such as coffee and energy drinks, often together with foods that contain fats. Because caffeine is sometimes linked to weight loss and metabolism, I w…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
About 125 million people in the U.S. are affected by inflammatory disorders; despite this, there are no viable cures for these conditions. Many researchers have turned away from natural prod…
ISEF · 2026
Cellular and Molecular Biology
Translation initiation is a major control point in bacterial gene expression, yet how initiation factors affect population level growth remains poorly quantified, specifically under environm…
ISEF · 2026
Cellular and Molecular Biology
Insulin-like growth factor 2 (IGF-2) is a regulatory peptide involved in neuroplasticity, memory consolidation, and neuroprotection in the CNS. Despite the well-documented association betwee…
ISEF · 2026
Cellular and Molecular Biology Third Award
Isoflurane is an FDA-approved volatile anesthetic used to induce and maintain general anesthesia. Isoflurane hyperpolarizes membrane potential by selectively enhancing K+ channels and inhibi…
ISEF · 2026
Cellular and Molecular Biology Second Award
Drug combination therapy is a cornerstone of modern oncology, but identifying effective combinations for a patient's specific tumor remains difficult as possible combinations grow rapidly wi…
CSEF · 2026
Biochemistry/ Molecular Biology (Senior Division)
This project investigates the effects of three synthetic chalcones, compounds 17, 25, and 30, on Caenorhabditis elegans. This nematode species was used as a non-parasitic model for plant-par…
ISEF · 2026
Cellular and Molecular Biology
Glioblastoma is a highly aggressive and treatment-resistant brain tumor with a five-year survival rate of 6.9%, necessitating exploration of novel therapeutic strategies. Transient receptor…
ISEF · 2026
Cellular and Molecular Biology Fourth Award
Cardiovascular disease remains the leading global cause of mortality, with myocardial infarction resulting in permanent myocardial loss due to the limited regenerative capacity of adult card…
ISEF · 2026
Cellular and Molecular Biology
MicroRNAs (miRNAs), small noncoding RNA genes, play crucial roles in regulating gene expression in human development and cancer. The let-7 miRNA is involved in various cellular processes, in…