38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2023
Cellular and Molecular Biology
Beta Carotene is an important organic compound with a bright orange color naturally produced in plants. It is hailed for its health benefits and antioxidant properties. In a previous study,…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
The pandemic-induced decline in colonoscopies and the continuing rise of colorectal cancer (CRC) rates in younger populations makes the need for early CRC indicators higher than ever. The ro…
CSEF · 2023
Biochemistry/ Molecular Biology Honorable_mention Award
Chronic Hepatitis B virus (HBV) infection affects 300 million people worldwide, with no existing cure. The first-line treatment is interferon (IFN), an antiviral cytokine. However, clinical…
CSEF · 2023
Biochemistry/ Molecular Biology Honorable_mention Award
Here We Grow Again Caleb Sunia Northcreek Christian Academy We all enjoy apples but some take so long to ripen and so many go to waste. This experiment will also help farmers by growing thei…
CSEF · 2023
Biochemistry/ Molecular Biology Second Award
Background: Rising healthcare costs and negative impacts on quality of life are challenges faced by the elderly suffering from neurodegenerative diseases, involving neuroinflammation such as…
CSEF · 2023
Biochemistry/ Molecular Biology Second Award
Today, it takes >14 years, $2B to develop a new drug. A faster, cheaper way to inhibit newly-discovered disease targets would greatly benefit patients. The purpose of this project is to test…
ISEF · 2023
Cellular and Molecular Biology
The current paradigm in genetics states that mutation is random. However, recent studies with Arabidopsis thaliana have shown that the mutation rate and rate of expression of a gene are nega…
ISEF · 2023
Cellular and Molecular Biology Second Award
Over $10.8 billion is spent each year in various oncology clinical trials. However, only 3.4% of those trials succeed. This is because of the lack of precision in the selection of targets to…
ISEF · 2023
Cellular and Molecular Biology
The proper formation of a zygote requires extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation. In C. elegans, this reprogramming is mediated by the H3…
ISEF · 2023
Cellular and Molecular Biology
Although UC-MSCs are preferred for clinical administration, they are retrieved in minute amounts. The scale-up requirement for human consumption is 1 million cells/kg of body weight. This de…
ISEF · 2023
Cellular and Molecular Biology Third Award
It has become increasingly apparent that a person’s environment has the potential to alter gene expression via the transgenerational inheritance of non-DNA factors. These factors likely accu…
CSEF · 2023
Biochemistry/ Molecular Biology Honorable_mention Award
Our bodies are continuously faced with a variety of genetic and developmental stress and use stress-responsive signaling pathways to safeguard cells from these insults. These pathways therea…
ISEF · 2023
Cellular and Molecular Biology
Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) are all classified as neurodegenerative disorders. In many neurodegenerative diseases, TDP-43…
ISEF · 2023
Cellular and Molecular Biology
Cellular mechanosensation is an important biological function that enables cells to sense the mechanical cues of its extracellular environment and to change phenotypes and cell lineage accor…
ISEF · 2023
Cellular and Molecular Biology
Paxillin is a known regulator of focal adhesions and actin cytoskeleton dynamics, crucial for cell migration. However, our study discovered a novel function of paxillin in neurons. We found…
ISEF · 2023
Cellular and Molecular Biology
Purpose: Though the behavioral effects of transcranial direct current stimulation (tDCS) are well-documented, a gap exists in current literature on its effects on glymphatic system dynamics…
ISEF · 2023
Cellular and Molecular Biology
This study aimed to determine if Drosophila melanogaster PFK (DmPFK) forms filaments, and if so, under what conditions. Enzyme filamentation, or the reversible formation of oligomers, has be…
CSEF · 2023
Biochemistry/ Molecular Biology Honorable_mention Award
Glioblastoma (GBM) is the most common malignant adult brain tumor. With minimal clinical innovation, the prognosis for GBM patients remains grim. However, there is a commonality between 83%…
CSEF · 2023
Biochemistry/ Molecular Biology Fourth Award
Cancer is the second highest cause of death in the U.S. per year. Cannabidiol, CBD, is a phytocannabinoid found in the plant cannabis sativa and could have properties helping against cancer.…
ISEF · 2023
Cellular and Molecular Biology
Acod1 is a gene that codes for immune response gene 1 (IRG1), an enzyme that converts TCA cycle intermediate cis-aconitate into itaconate. Itaconate exerts multiple biological effects, from…
ISEF · 2023
Cellular and Molecular Biology Second Award
Type 2 Diabetes (T2D) affects millions worldwide but has an exceptionally high prevalence in Hawaii, with a rate of 9% for all residents aged 18 or older. Of that 9%, 13.1% are Native Hawaii…
CSEF · 2023
Biochemistry/ Molecular Biology (Senior Division)
Background: Aging-associated oxidative stress and free radical generation leads to collagen degradation and subsequent reduced skin elasticity, bone degeneration and organ dysfunction. Omega…
ISEF · 2023
Cellular and Molecular Biology
Proper cellular morphology and plasma membrane structure during interphase are integral for proper mitosis and homeostasis. Tumor suppressor PTEN (Phosphatase and TENsin homologue deleted on…
ISEF · 2023
Cellular and Molecular Biology Third Award
Current research is focused on identifying drugs that can mitigate chemotherapy-induced injury to normal tissues, while being cytotoxic to cancer cells. This study was designed to evaluate t…
ISEF · 2023
Cellular and Molecular Biology
A class of type II diabetes medication interacts with a nuclear receptor known as PPAR?. While these drugs are effective at managing type II diabetes, however, they have dangerous side effec…
ISEF · 2023
Cellular and Molecular Biology Second Award
As mRNA-based therapeutics like COVID-19 vaccines rapidly evolve, degradation remains a key limiter of efficacy and distribution. Circular RNAs (circRNAs) possess a closed-loop structure, co…
CSEF · 2023
Biochemistry/ Molecular Biology First Award
As mRNA-based therapeutics like COVID-19 vaccines rapidly evolve, degradation remains a key limitation. Circular RNAs (circRNAs) possess a closed-loop structure, conferring enhanced stabilit…
CSEF · 2023
Biochemistry/ Molecular Biology Third Award
Ethanol is a renewable, domestically produced transportation fuel. Overall, the transportation sector accounts for approximately 30% of total U.S. energy needs and 70% of U.S. petroleum cons…
ISEF · 2023
Cellular and Molecular Biology Fourth Award
Pancreatic cancer is among the world's deadliest cancers with a 5-year survival rate below 9%. Pancreatic ductal adenocarcinoma (PDAC) encompasses >90% of all pancreatic cancers, and >95% ar…
ISEF · 2023
Cellular and Molecular Biology Third Award
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are two types of hematologic malignancies with especially poor prognoses and limited therapeutic options. Notably, mutations i…