Browse real student projects, abstracts, and awards.
ISEF · 2019
Cellular and Molecular Biology
The serine protease inhibitor-2 (Serp-2) gene is a virulence factor of the myxoma virus, an immunosuppressive disease found in European rabbits. This gene inhibits the proteases caspase-1 an…
ISEF · 2019
Cellular and Molecular Biology
The purpose of this research is to determine if isolating exosomes in urine and saliva can increase constancies in the capillary tube precipitation test. This, in turn, could diagnosis IgE s…
ISEF · 2019
Cellular and Molecular Biology
Current research suggests that toxic tau aggregates propagate from neuron to neuron in a prion-like manner. However, no dynamic proof exists to trace tau’s transmission and traffic in neurod…
ISEF · 2019
Cellular and Molecular Biology
Hypoxia (reduced oxygen) is common in many brain tumors, including gliomas. Hypoxia Inducible Factor 1 Alpha (Hif-1a) is upregulated and stabilized under hypoxic conditions, leading to tumor…
ISEF · 2019
Cellular and Molecular Biology
This research project seeks to analyze the characterization of the Human Epidermal Growth Factor Receptor (HER2) and the Dopamine Receptor D2 (DRD2) that is overexpressed in cancer cells. Th…
ISEF · 2019
Cellular and Molecular Biology
This project investigates the impact of Diethyl phthalate on cells of Allium cepa L, by measuring alterations in mitotic index, of the organism’s roots. The main factor that justifies this i…
ISEF · 2019
Cellular and Molecular Biology
Cells are composed of membraneless organelles that form through self-assembly of intrinsically disordered proteins (IDPs). These IDPs are thought to self-associate to form mesoscale protein…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
During the progression of metastatic cancer, peripheral cells break away from the primary tumor and acquire the ability to intravasate into the circulatory and lymphatic systems. These invas…
ISEF · 2019
Cellular and Molecular Biology
Cancer cells have a homing ability and are able to track cells of their own kind. Because of this constant communication and close proximity, cancer cells could be used as targeted weapons t…
ISEF · 2019
Cellular and Molecular Biology
The goal of this research is to find a cure for cancer. Breast and Cervical cancers are very aggressive forms of cancer. Polyphenols, in green tea, have an anti-cancer effect. Phase I resear…
ISEF · 2019
Cellular and Molecular Biology
Stem cell therapy is a novel and promising strategy that shows strong potential to treat heart disease, particularly heart attacks (myocardial infarction) and heart failure. Stem cells are u…
ISEF · 2019
Cellular and Molecular Biology
Over the past decade, honey bee populations have been declining due to the phenomenon known as Colony Collapse Disorder (CCD). Nosema ceranae is a microsporidian parasite that has recently b…
ISEF · 2019
Cellular and Molecular Biology
Sterol regulatory element binding protein 1 (SREBP-1) is a master transcriptional regulator that controls the transcription of genes required for lipid and fatty acid production. Previous st…
ISEF · 2019
Cellular and Molecular Biology
In traditional Chinese medicine, sea cucumbers are commonly eaten to treat blood and kidney problems, which is why it was hypothesized that the sea cucumber species Holothuria cinerascens an…
ISEF · 2019
Cellular and Molecular Biology
Woody plants are important resources for paper productions, strategies for improvement of their properties are of considerable interest. The UP hybrid eucalyptus plants have fast-growth, goo…
ISEF · 2019
Cellular and Molecular Biology
Using different inhibitors to stop the cell cycle in different phases, we will see significant differences in DNA damage. In S-phase, we find DNA synthesizing, whereas in M-phase, DNA has co…
ISEF · 2019
Cellular and Molecular Biology
The purpose of this project was to compare fungal communities associated with soybean roots both before and after fungicide to identify unknown fungi that responds to fungicide application.…
ISEF · 2019
Cellular and Molecular Biology
Head and neck squamous cell carcinomas (HNSCC) are aggressive tumors with high recurrence rates and poor patient survival. Although HNSCCs only account for 3% of cancers in the United States…
ISEF · 2019
Cellular and Molecular Biology
Purpose: GBM (glioblastoma multiforme), a primary brain tumor, exhibits more invasive and malignant behavior when developed proximal to the subventricular zone (SVZ) of the brain. A unique f…
ISEF · 2019
Cellular and Molecular Biology
The ribosomal production of the nucleoli of cells control metabolism (rate of protein production) as an organism ages. This experiment was designed to show the relationship between the age o…
ISEF · 2019
Cellular and Molecular Biology
Currently, there is no cure for Type 1 Diabetes; however, a potential lead in the field of Juvenile Diabetes research is the Bio-Artificial Pancreas. This system essentially encapsulates mat…
ISEF · 2019
Cellular and Molecular Biology
UVB radiation has been known to cause skin cancer by destroying cellular structures and creating mutations in DNA. UVB radiation (from sun) causes repeated cell DNA damage and destroys life…
ISEF · 2019
Cellular and Molecular Biology
While chemotherapy and targeted therapy are common cancer treatments, both have limitations. Induced apoptosis is an attractive alternative. Mitochondrial apoptosis is controlled by the BCL-…
ISEF · 2019
Cellular and Molecular Biology
Ixodes scapularis (black-legged ticks) infected with Borrelia burgdorferi, the causative agent of Lyme disease, is endemic throughout the upper Midwest. Over the most recent years, the numbe…
ISEF · 2019
Cellular and Molecular Biology
Huntington’s disease (HD) is a fatal neurodegenerative disorder which affects around 1 in every 10,000 people. This autosomal dominant genetic disorder is caused by an expansion of the polyg…
ISEF · 2019
Cellular and Molecular Biology
Nicotinic acetylcholine receptors, or nAChRs, form the basis of nicotine addiction. The ALPHA4BETA2ALPHA5 nAChR is the focus of this study. When an individual uses, either a cigarette or an…
ISEF · 2019
Cellular and Molecular Biology
The retrograde nuclear import is an important and conserved step in tRNA quality control in eukaryotes and is taken advantage of by retroviruses such as HIV to infect cells. Retrograde impor…
ISEF · 2019
Cellular and Molecular Biology
Glioblastoma multiforme is the most aggressive form of brain cancer (<5% of people diagnosed survive for longer than 5 years), with no specific treatment or prevention. For many types of can…
ISEF · 2019
Cellular and Molecular Biology Fourth Award
Melanoma, a tumor arising from melanocytes, is responsible for most skin cancer deaths. Familial melanoma is linked to germline mutations in the CDKN2A (p16) tumor suppressor gene, which reg…
ISEF · 2019
Cellular and Molecular Biology
If the effects of X-inactivation are observed with tortoiseshell cats, then it will be determined that lyonization is random and not predetermined because each female cell designates X chrom…