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How Do Genetics Affect the Way People Respond to Drugs?

CSEF · 2019 Biochemistry/ Molecular Biology

Arianne G. Daw · St. Rita's Catholic School, San Diego, San Diego County

Overview

Objectives The purpose of my project is to figure out why some people have a better response to drugs than others. Methods Materials: Laptop, Writing Utensils, Notecards, PharmGKB.org, NCBI SNP database I tested my hypothesis by using the PharmGKB website to find alleles associated with alternate responses to the drugs. I then used the NCBI SNP database to find out whether the SNP is in an exon, intron, or near the gene. Results I found that some people had an increased or decreased response to the drugs, based on their genetic makeup. I discovered that the SNPs and different alleles played a part in the drug responses. Conclusions I realized that not everyone has the same response to a certain drug. Because of the differences in out DNA, such and SNPs, some have an increased response to drugs, while others have a decreased response. Although some mutations do not occur in the coding part of the gene, they may still have an effect on the response to the drug.

Summary statement

I showed that differences in genetics affected the responses people have to drugs.

Help received

I conducted the research and experiment myself.

Competition history

  • CSEF 2019 Biochemistry/ Molecular Biology · Entry J0505

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