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The Kirsten rat sarcoma viral (KRAS) gene is the most frequently mutated oncogene, responsible for many types of highly fatal cancers — notably, pancreatic, colorectal, and non-small cell lu…

CSEF · 2023

Hepatitis B patient-derived virus exhibits replication step-dependent resistance to Interferon in a chronic in-vitro infection model

Biochemistry/ Molecular Biology Honorable_mention Award

Chronic Hepatitis B virus (HBV) infection affects 300 million people worldwide, with no existing cure. The first-line treatment is interferon (IFN), an antiviral cytokine. However, clinical…

CSEF · 2023

Here We Grow Agian

Biochemistry/ Molecular Biology Honorable_mention Award

Here We Grow Again Caleb Sunia Northcreek Christian Academy We all enjoy apples but some take so long to ripen and so many go to waste. This experiment will also help farmers by growing thei…

CSEF · 2023

Human Dermal Fibroblasts As A Novel Therapeutic Agent For Neuroinflammation

Biochemistry/ Molecular Biology Second Award

Background: Rising healthcare costs and negative impacts on quality of life are challenges faced by the elderly suffering from neurodegenerative diseases, involving neuroinflammation such as…

CSEF · 2023

Identifying Novel Kinases for Approved Drugs using a Convolutional Neural Network Autoencoder and AlphaFold

Biochemistry/ Molecular Biology Second Award

Today, it takes >14 years, $2B to develop a new drug. A faster, cheaper way to inhibit newly-discovered disease targets would greatly benefit patients. The purpose of this project is to test…

CSEF · 2023

Mapping Gene Function on Regulatory Networks of the Unfolded Protein Response

Biochemistry/ Molecular Biology Honorable_mention Award

Our bodies are continuously faced with a variety of genetic and developmental stress and use stress-responsive signaling pathways to safeguard cells from these insults. These pathways therea…

CSEF · 2023

Novel Strategies for the Reversal of Cancer Cell Immortality

Biochemistry/ Molecular Biology Honorable_mention Award

Glioblastoma (GBM) is the most common malignant adult brain tumor. With minimal clinical innovation, the prognosis for GBM patients remains grim. However, there is a commonality between 83%…

CSEF · 2023

Observing the Effects of Different Concentrations of CBD on Cancer in Drosophila Model

Biochemistry/ Molecular Biology Fourth Award

Cancer is the second highest cause of death in the U.S. per year. Cannabidiol, CBD, is a phytocannabinoid found in the plant cannabis sativa and could have properties helping against cancer.…

CSEF · 2023

Protective Effects of Omega-3 Fatty Acids Against Oxidative Stress-induced Collagen Degradation of Tilapia Fish Scales

Biochemistry/ Molecular Biology (Senior Division)

Background: Aging-associated oxidative stress and free radical generation leads to collagen degradation and subsequent reduced skin elasticity, bone degeneration and organ dysfunction. Omega…

CSEF · 2023

Quantification and Optimization of Circular RNA Stability for Improved RNA Therapeutics

Biochemistry/ Molecular Biology First Award

As mRNA-based therapeutics like COVID-19 vaccines rapidly evolve, degradation remains a key limitation. Circular RNAs (circRNAs) possess a closed-loop structure, conferring enhanced stabilit…

CSEF · 2023

Reaction Analysis with Colorimetric Measurement of Starch Solution

Biochemistry/ Molecular Biology Third Award

Ethanol is a renewable, domestically produced transportation fuel. Overall, the transportation sector accounts for approximately 30% of total U.S. energy needs and 70% of U.S. petroleum cons…

CSEF · 2023

Uncovering the Anti-Prostate Cancer Properties of Four Central California Weeds

Biochemistry/ Molecular Biology Third Award

Better therapeutics for prostate cancer are needed because over 34,000 American men are estimated to die of prostate cancer in 2022. Natural products have been a valuable source of anticance…

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