38,465 real projects from ISEF, the Canada-Wide Science Fair, JSHS, AJAS, the Calgary Youth Science Fair and the California Science & Engineering Fair — searchable by meaning, and filterable by fair, year, category and award.
ISEF · 2025
Translational Medical Science Fourth Award
Cancer remains one of the most significant global health challenges, with the c-MYC proto-oncogene implicated in over 50% of cases, particularly in solid tumors. When dysregulated, c-MYC pro…
ISEF · 2025
Plant Sciences Fourth Award
The limited variety of weed suppression treatments has contributed to herbicide resistance in several invasive species, threatening crop yields and global food security. Allelopathy—the natu…
ISEF · 2025
Cellular and Molecular Biology Fourth Award
Toxic methylmercury (MeHg) readily crosses the blood brain and placental barriers, leading to developmental delays and neurological issues particularly with in utero exposure. Upon exposure,…
ISEF · 2025
Animal Sciences Fourth Award
Early-onset colorectal cancer (EOCRC) in patients under 50 now accounts for 10% of new diagnoses. While unexplained, trends in EOCRC may be related to diet, which is associated with 29% of a…
ISEF · 2025
Biomedical and Health Sciences Fourth Award
Pediatric sarcomas comprise approximately 10% of childhood solid tumors, with metastatic disease yielding survival rates as low as 20-25%. Despite many efforts, advancements in survival outc…
ISEF · 2025
Systems Software Fourth Award
Computers are everywhere today, and digital traces often remain that can help reconstruct past events. When available, computer forensic artifacts can be crucial in establishing guilt or inn…
ISEF · 2025
Engineering Technology: Statics & Dynamics Fourth Award
With the increasing use of high-performance CPUs and GPUs, thermal management has become crucial. Conventional cooling methods, such as heat sinks and air coolers, often generate continuous…
ISEF · 2025
Biomedical and Health Sciences Fourth Award
Age-related macular degeneration, or AMD, is a progressive degeneration of the retina that causes significant central visual impairment, impacting nearly 20 million elderly adults in the Uni…
ISEF · 2025
Computational Biology and Bioinformatics Fourth Award
Drug-drug synergy is crucial for developing effective combination therapies, and gene function relationships play an important role in identifying these synergies. However, due to the comple…
ISEF · 2025
Behavioral and Social Sciences Fourth Award
Native Hawaiian and Pacific Islanders (NHPI) suffer disproportionately from cardiometabolic health conditions, with diabetes mortality rates 3.32 times higher than the general population, ye…
ISEF · 2025
Cellular and Molecular Biology Fourth Award
Introduction: Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest malignancies due to late diagnosis, extensive metastasis, and limited treatment options. A multifunctional g…
ISEF · 2025
Biomedical Engineering Fourth Award
Diabetic foot ulcers (DFUs) are a major cause of lower-limb amputations, with over 160,000 diabetics in the United States undergoing amputations annually. This project presents an AI-powered…
ISEF · 2025
Biomedical and Health Sciences Fourth Award
Congenital heart defects (CHDs) refer to structural defects in the heart that are present at birth. Hypoplastic Left Heart Syndrome (HLHS) is the most complex CHD and occurs when the left si…
ISEF · 2025
Translational Medical Science Fourth Award
Rheumatoid Arthritis (RA) is an autoimmune arthropathy that affects over 18 million people globally, causing immense joint pain and swelling. Current treatments (e.g., methotrexate, adalimum…
ISEF · 2025
Biomedical and Health Sciences Fourth Award
Inflammation is the body's natural response to combat infections, allergies, or injuries. The most commonly available treatments—non-steroidal anti-inflammatory drugs (NSAIDs) and corticoste…
ISEF · 2025
Environmental Engineering Fourth Award
Water pollution is a global issue, with sources ranging from industrialization and agricultural activities, to natural disasters like wildfires. These fires are especially concerning as they…
ISEF · 2025
Embedded Systems Fourth Award
This study investigates various audio preprocessing techniques for classifying lung sounds, particularly Per-Channel Energy Normalization (PCEN). We combined and augmented two primary datase…
ISEF · 2025
Biomedical and Health Sciences Fourth Award
Duchenne Muscular Dystrophy (DMD) is an inherited X-linked disease with an incidence of 1:3,600. Patients become weak at 2-3 years old with progression to respiratory failure and death in th…
ISEF · 2025
Technology Enhances the Arts Fourth Award
OpenAI's ChatGPT has blurred the line between human and AI-written text, challenging academia's ability to verify authorship. Existing AI detection systems fail with paraphrased content or m…
ISEF · 2025
Biomedical and Health Sciences Fourth Award
Immune checkpoint inhibitors (ICIs) have emerged as a promising therapy for late-stage lung cancer. However, the response rate to ICIs remains low. As a result, there is a need to better und…
ISEF · 2025
Embedded Systems Fourth Award
Artificial Intelligence (AI) has become a cornerstone of global innovation. However, current digital hardware, such as GPUs, faces critical computational bottlenecks with the growth of next-…
ISEF · 2025
Physics and Astronomy Fourth Award
Recent discoveries like GJ 9827 d's water-rich atmosphere have brought to light an understudied class of exoplanets—water worlds. The discovery of water in this exoplanet atmosphere simultan…
ISEF · 2025
Biomedical Engineering Fourth Award
The continuous monitoring of human physiological health without the presence of a doctor has been a recent subject of innovation. A popular method for detecting various factors involves anal…
ISEF · 2025
Environmental Engineering Fourth Award
Access to treated water is a challenge in many communities around the world. Globally, 2.2 billion people do not have access to drinking water. In Brazil, over 33 million people face this pr…
ISEF · 2025
Robotics and Intelligent Machines Fourth Award
The main goal is to build a robot that can manage plant diseases autonomously for efficient disease management in agriculture. Conventional approaches are time-consuming, laborious, and inac…
ISEF · 2025
Animal Sciences Fourth Award
Anti-apoptotic B-cell leukemia/lymphoma (Bcl-2) family proteins are reported to be overexpressed in around half of all human cancers, linked to tumorigenesis, chemotherapy resistance, and po…
ISEF · 2024
Computational Biology and Bioinformatics Fourth Award
The ability to visualize cell behavior within the 3-dimensional space of a tissue is invaluable for understanding cell function. Although open-source and professional software exist to analy…
ISEF · 2024
Translational Medical Science Fourth Award
Wound care is an essential part of patient healthcare. However, infections worldwide are increasing at a record rate due to disease, microbes, and antibiotic resistance. Unfortunately, preve…
ISEF · 2024
Translational Medical Science Fourth Award
Arsenic is toxic. The primary goal of this research is to scientifically detect and quantify arsenic levels in drinking water due to local residents’ concerns and assess the potential health…
ISEF · 2024
Earth and Environmental Sciences Fourth Award
Plastic pollution, with an annual human ingestion rate of approximately 1.38 million grams/per year, requires sustainable alternatives. The development of biodegradable bioplastics from alga…