The Salt to My Pepper: Utilizing the Bioactive Descriptors of Piperoyl Piperidine on Drosophila Melanogaster as a Neoteric Treatment for Breast Cancer

Overview

Breast cancer occurs from contingency of malignant cells spreading through the bloodstream, affecting 2.3 million individuals globally, with HER2+ being an invasive subtype due to HER2 protein overexpression. However, current medications slow tumor growth rather than eliminate it, whereas the rapies eliminate it but also diminish healthy cells; causing it to be not tailored to physical side effects. This research aimed to assess piperoyl -piperidine, a component in black pepper, effects on HER2+ breast cancer in Drosophila melanogaster, focusing on its potential to reduce cell proliferation, increase mobility, eating habits, and survivorship. It is hypothesized that higher doses of piperoyl -piperidine would yield a tumor growth inhibition (TGI) rate greater than 50%, along with reduced cancerous phenotypic traits. Three concentrations of piperoyl-piperidine were tested: T -1 at 0.1 μM, T -2 at 0.2 μM, and T -3 at 0.3 μM over a period of 10 days. T -3 demonstrated a TGI of 80.11%, T -2 showed 68.22%, and T -1 showed 44.84%, with higher concentrations ass ociated with tumor reduction, greater mobility patterns, eating habits, and survivorship. Both t and p value analysis confirmed that each variable tested rejected the null hypothesis and deemed as significant statistical difference. Future research will test higher doses and explore its effects on various cancers, contributing to a diverse set of patient populations. By understanding the inhibitory effect of piperoyl -piperidine on HER2+ breast cancer, we can accumulate extensive knowledge involved with cancer onset and growth. From there, we are one step closer to a cure. Virginia