Modeling Drug Side-Effect Burden on Organ Systems
CWSF · 2026 Health & Wellness Bronze Medal
Overview
With a growing and aging population taking an increasing number of prescription medications every year, adverse drug reactions are becoming increasingly common. Despite this, most clinical decision-support tools focus on known drug–drug interactions, which are typically pairwise and limited to curated interactions. This may overlook broader system-wide stress on organ systems arising from overlapping drug side-effects. This project addresses that critical gap by analyzing entire medication regimens rather than individual drug pairs in isolation. Using statistical methods, it identifies physiological stress from overlapping side-effects and shared drug targets, quantifying how polypharmacy regimens concentrate burden across organ systems. To detect any unusual patterns, a null model compares real regimens against randomly generated ones matched by size and drug class. By developing this computational model using data from publicly available databases, we can reveal hidden risks of side-effects associated with multi-drug regimens, hoping to improve medication safety and management.
Awards (3)
- Special Award
- Bronze Medal
- Selected for CWSF 2026
Competition history
- CWSF 2026
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