fairfolio
Saved Projects

Metabolic Dysfunction and CIN: Investigating Diabetes as a Risk Factor for Hsils

AJAS · 2026 Biomedical and Health Sciences (inferred)

Priya Kumar · Virginia Academy of Science

Overview

Cervical cancer remains a major public health concern, with disparities in incidence and mortality disproportionately affecting non-Latine (nL) Black women. Diabetes has been implicated in cancer progression due to its impact on immune function, inflammation, and metabolic dysregulation. However, its role in cervical intraepithelial neoplasia (CIN) progression, particularly in racially diverse populations, remains underexplored. This study examines the association between diabetes and high-grade squamous intraepithelial lesions (HSIL) and assesses racial disparities in CIN progression, with a focus on nL Black women. A retrospective cohort study was conducted using electronic health records from Virginia Commonwealth University Health System (VCUHS) between 2014 and 2021. The study included 2,189 women diagnosed with CIN, stratified by diabetes status and race. Multivariable logistic regression models assessed the association between diabetes and HSIL risk while controlling for demographic and clinical covariates. Despite the higher overall cervical cancer burden among nL Black women, a lower proportion of HSIL diagnoses was observed compared to nL White women. Diabetes was significantly associated with an increased risk of HSIL, particularly among nL Black women. The risk of HSIL was nearly sevenfold higher in Black women with diabetes compared to their counterparts without diabetes. These findings underscore the role of metabolic dysfunction in cervical cancer progression and highlight the need for integrating diabetes management into cervical cancer prevention efforts. Future research should explore targeted interventions, address social determinants of health, and foster interdisciplinary collaborations to mitigate disparities and improve outcomes.

Competition history

  • AJAS 2026 Category not listed

Related projects

Closest projects by meaning, across every fair and year in the corpus.

Browse more like this

Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

Save projects to your library

Sign in with Google to keep track of projects you find interesting, organized into folders. An account also raises your daily allowance for “Has this been done?”, and lets you create a key for the MCP server with a much higher limit than anonymous use. Browsing stays public.

Continue with Google