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Humanin and Daf-2 Increase C. elegans Lifespan and Memory Functionality

CSEF · 2016 Zoology

Hongjia (Ashley) Yang · Palisades Charter High School, Pacific Palisades, Los Angeles County

Overview

Objectives/Goals The objective of this study is to determine the effects of humanin and daf-2 on C. elegans' longevity and memory function, as a preliminary study in understanding their effects on human longevity and memory function. Methods/Materials Use C. elegans with and without humanin and daf-2 genes as a model system to examine the lifespan and memory function in response to chemotaxical cue (butanone) at various time points. Results Results show C. elegans expressing humanin and daf-2 had increased lifespan and momory functionality, and even more so for C. elegans with the crossed humanin/daf-2 genes. Conclusions/Discussion These findings indicate that humanin and daf-2 can improve C. elegans' lifespan and momory function. It also suggest from this study that humanin and daf-2 or equivalent proteins in human may plan important roles in anti-aging.

Summary statement

Humanin and daf-2 increase C. elegans lifespan and memory functionality

Help received

I designed and performed the experiments by myself. I got help in understaining the science about C. elegans and relevant genes from Dr. Pinchas Cohen, Dean, USC Davis School of Gerontology and Dr. Kelvin Yen, Research Assistant Professor, USC Davis School of Gerontology

Competition history

  • CSEF 2016 Zoology · Entry S2214

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