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Understanding CG7900, a Drosophila Gene Important for Lifespan

CSEF · 2003 Biochemistry/ Molecular Biology

Richard Hsu · Alhambra High School, Alhambra

Overview

Objectives/Goals Aging is a universal process among organisms in which homeostasis decreases and chance of death increases. Trying to understand aging in a lower organism, such as Drosophila, is a possible intermediate step process in understanding aging in humans. Methods/Materials An overexpression screen using the gal4 upstream activation sequence binary system was performed to identify long-lived mutants. In addition, a genomic transgenic was replicated to verify that overexpression of CG7900 extends lifespan in an independent line. A recombinant was made between EP3306 and the daughterless driver to look at interactions with other long-lived lines in the lab. Results Results show that CG7900 is the cause of increased lifespan and the gene itself seems to play a vital role in the metabolism process. Conclusions/Discussion In conclusion, the CG7900 plays a crucial role in the extension of lifespan, which may be a stepping-stone for aging research.

Summary statement

The CG7900 gene plays a vital role in the extension of Drosophila lifespan, which may be a key factor in understanding aging.

Help received

Used lab equipments at Caltech under the supervision of Brian Zid. Special thanks to my parents for providing transportation when needed.

Awards (1)

  • Category Award

Competition history

  • CSEF 2003 Biochemistry/ Molecular Biology · Entry S0408

Resources

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