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HA Paired with Antioxidants for Treatment of CMV-Induced Sensorineural Hearing Loss

AJAS · 2019 Biomedical and Health Sciences (inferred)

Zoe Peach-Riley · Montana Academy of Sciences

Overview

Cytomegalovirus (CMV) is the leading non-genetic cause of sensorineural hearing loss (SNHL) in children in the United States. Current antiviral treatments exist, however with only modest short-term improvements and uncertain long-term outcome as well as reports of complications. Because CMV causes SNHL through inflammation and oxidation of the inner ear, an anti-inflammatory compound such as hyaluronic acid (HA) can be modified and combined with an antioxidant compound like D-methionine as a potential treatment. Preliminary results indicate successful synthesis of the compound CMHA+D-methionine as well as demonstrated cytocompatibility. Upcoming procedures will include testing the combined anti-inflammatory and antioxidant effects of the novel compound CMHA+D-methionine and investigating its potential to act as an effective treatment for CMV SNHL.

Competition history

  • AJAS 2019 Category not listed

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Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

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