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Exploring the Role of Circulating miR-134 in Breast Cancer Recurrence

ISEF · 2019 Biomedical and Health Sciences

Chen, Lauren · Dutch Fork High School

Overview

MicroRNAs (miRNAs) are short sequences of RNA (about 22 nucleotides) that are involved in the regulation of gene expression. My previous study has identified the serum miR-134 as a new biomarker to predict breast cancer recurrence after primary treatment. To further study the function of miR-134 in breast cancer progression, I transfected miR-134 into breast cancer and macrophage cells. I found that overexpression of miR-134 had no effect on tumor cell proliferation but induced macrophage phenotypic changes. Interestingly, the conditioned medium from miR-134 overexpressed macrophage cells promoted the growth of tumor cells. My results suggested that circulating miR-134 may promote tumor progression and recurrence by potentially mediating the interaction between tumor cells and immune cells.

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Source: Regeneron International Science and Engineering Fair

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