Endocannabinoids: From Drosophila Physiology and Autophagy Regulation to Therapeutic Insights

Overview

The endocannabinoid system (ECS) and autophagy are both essential physiological mechanisms within cells. However, limited research explores the relationship between endocannabinoids, specifically 2-AG, and autophagy. We have chosen to study Drosophila as our research subject to examine the impact of endocannabinoids from an organism perspective. We believe that Drosophila can serve as an initial research platform, providing a more convenient method for studying both exogenous and endogenous cannabinoids. In this study, we manipulated the levels of 2-AG in Drosophila by modulating the expression of synthetic and degrading enzymes, MAGL and DAGL. When MAGL was inhibited, the lifespan, anti-starvation ability, and autophagy of Drosophila increased, while DAGL was inhibited or overexpressed, such functions suppressed. By adding autophagy inhibitors, we confirmed the relationship between autophagy and physiological functions. These findings could be beneficial to the efficiency of cannabinoid drug applications and mitigate side effects on the nervous system and liver function.

Awards (1)

• Fourth Award of $500 $500

Competition history

• ISEF 2024 Animal Sciences · Entry ANIM014T · Los Angeles, California, United States Affiliated fair in Taiwan

Resources

• ISEF abstract page ↗

Related projects

Closest projects by meaning, across every fair and year in the corpus.

Browse more like this

• All Animal Sciences projects
• ISEF Animal Sciences projects
• Every ISEF 2024 project
• ISEF Fourth Award of $500 winners