fairfolio
Saved Projects

Effect of Transcriptome Regulation on Glioblastoma Patient Survival

AJAS · 2020 Biomedical and Health Sciences (inferred)

Michelle Dong · Lindsay Stetson and Jill Barnholtz-Sloan, Ohio Academy of Science, The

Overview

Glioblastoma is the most common primary brain tumor in adults. Patients have a poor outcome with a median survival time of 12 months; the disease is always fatal. Long non-coding RNAs have been shown to play an important role in regulating gene expression, but their significance in glioblastomas is unclear. This study aimed to identify long non-coding RNA associated with the survival time of glioblastoma patients. The R package DESeq2 quantified the relative differential expression of aligned long non-coding RNA. The package was used to normalize glioblastoma data from The Cancer Genome Atlas to determine the long non-coding RNAs differentially expressed (q-value < 0.01) between short-term survivors (n=46, overall survival < 9 months) and long-term survivors (n=30, overall survival > 18 months). Eleven long non-coding RNAs differentially expressed in glioblastoma patients were identified. LOXL1-2 and LOXL1-AS1 were highly expressed among short-term survivors. Understanding the role of transcriptomics in gene expression is critical for gaining insight into improved targeted drug treatment. Further directions include statistically analyzing long non-coding RNA in other independent data sets and biologically validating the impact of long non-coding RNA on gene expression and protein abundance.

Competition history

  • AJAS 2020 Category not listed

Related projects

Closest projects by meaning, across every fair and year in the corpus.

Browse more like this

Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

Save projects to your library

Sign in with Google to keep track of projects you find interesting, organized into folders. An account also raises your daily allowance for “Has this been done?”, and lets you create a key for the MCP server with a much higher limit than anonymous use. Browsing stays public.

Continue with Google