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Before it Begins: A Preventative Multi Layer Calcium Driven Framework for Alzheimer’s

CWSF · 2026 Disease & Illness

Sherdha Sharma · Intermediate Division · Grades 9–10

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Overview

Alzheimer’s disease is typically treated after symptoms appear, despite evidence that underlying changes begin years earlier. I investigated whether early calcium dysregulation and disrupted neural oscillations could act as a primary driver of disease progression (Palop & Mucke, 2016).I developed a multi-layer framework linking calcium signaling, gene regulation, and mitochondrial dynamics. The model shows how dysregulation can increase expression of genes such as BACE1, alter neuronal communication, and promote amyloid-beta imbalance (Vassar et al., 2009).I propose two connected systems: DeepNeuroGenX, a predictive platform that analyzes biomarker patterns to identify early disease risk, and Precision Epigenetic Rebalancing (PER), which could use AAV9 delivery to rebalance gene activity as a potential treatment approach.This is important because it shifts Alzheimer’s from late stage symptom management to early, biomarker guided prevention, potentially reducing disease progression before significant brain damage occurs.

Awards (1)

  • Selected for CWSF 2026

Competition history

  • CWSF 2026 Disease & Illness

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