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Aloe Vera: Enhancing Collagen Formation for Dermal Wound Healing in Porcine Skin

AJAS · 2025 Biomedical Engineering (inferred)

Navya Shah · New Jersey Academy of Science

Overview

This study determines the efficacy of Aloe vera sap in promoting collagen synthesis during the wound healing process, using burn-injured porcine skin as a model. Viable porcine skin samples were subjected to standardized burn injuries, followed by treatment with either Aloe vera gel, recombinant collagen gel (positive control), or no treatment (untreated control). Following a Sirius Red/Fast Green staining method and subsequent extraction of the dye bound to collagen, collagen production was quantitatively determined using UV-Vis spectrophotometry over a 3-day time course post-treatment. Immediately after burning, samples displayed a collagen content quantified at 0.68 OD. At 3 hours post-burn, Aloe-treated samples exhibited a notable increase in collagen protein content compared to untreated samples, though still lower than collagen gel-treated samples. After approximately two days, Aloe-treated wounds demonstrated a substantial enhancement in collagen production, approaching the positive control while significantly surpassing untreated controls. Concurrent with the UV-Vis spectrophotometry samples, further histological analysis using Sirius Red/Fast Green staining confirmed an increase in collagen deposition, as visualized using light microscopy at 40x and 100x magnification and verified quantitatively using Fiji. Results support that Aloe vera gel increases collagen synthesis and, therefore, may facilitate more efficient skin wound healing when compared to untreated controls, with performance approaching that of collagen gel, a well-established wound healing aid. These findings underscore the potential clinical application of Aloe vera in dermal wound management.

Competition history

  • AJAS 2025 Category not listed

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Source: AAAS Annual Meeting (Confex) / American Junior Academy of Science

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