Activating Endogenous Reporter Genes to Visualize CRISPR-activation (CRISPRa) Based Therapies

Overview

Imagine if we could control how cells behave when there is a disease in our body. Scientists are doing this by targeting the tiny survival manual inside our cells called DNA with a tool called CRISPR (Clustered Regularly Interspaced Short Palendromic Repeats) to help cells better fight diseases. However, once CRISPR is inside the body, it is impossible to see exactly where it is working and for how long. To solve this, I am evaluating a way to make cells glow on a special medical scanner called a PET scan. By turning on a specific gene that the scanner can "see," we can track exactly where the treatment is going. In cells that I worked with, I was able to test many different ways of turning on the light switch. This discovery helps research scientists and doctors ensure these life-changing treatments are reaching the right targets for better patient care.

Awards (1)

• Selected for CWSF 2026

Competition history

• CWSF 2026 Disease & Illness

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