A Comparative Analysis of Parasporin Families from Bacillus thuringiensis as Targeted Anti-Cancer Therapeutics

Overview

Bacillus Thuringiensis is a bacterium which, in a study led by Mizuki et. al. in 1999-2000, had been discovered to produce a variety of special Cry(Crystal) proteins in the pesticidal bacteria. Within the same year, 2000, the name “parasporin” was coined for these unique proteins which had been found to also exhibit anti-cancer properties, where certain families like Parasporin-2(PS2Aa1) facilitates cell death through pore-forming oligomerization on membrane lipid rafts, increasing permeability of the cell membrane, while Parasporin-1(PS1Aa1) induces apoptosis through rapidly increasing intracellular Ca2+ ion concentrations, facilitating cell death. However, in order to further increase our understanding of the clinical applicability of each of these parasporin families within different cancer cell lines and types, we will extract data from a variety of studies focusing on the LC50 concentrations of each parasporin family on each cell line, extracting data from studies off of Google Scholar, Pubmed, and Web of Science. From these, we will compare datasets in order to suggest a correlation between parasporin families showing clinical efficacy through comparing their LC50 values with control cell values. Our research shows that PS2 shows the highest broad-spectrum toxicity with high selectivity values and low dosages across leukemia, liver cancer, and endometrial cancer.

Competition history

• CSEF 2026 Medicine & Physiology (Track 2) (Senior Division) · Entry S-21-01

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