11705 projects whose affiliated fair was here, most recently in 2026.
ISEF records a state or province for some finalists and not others, so these counts do not add up to the country total.
11705 projects · showing 1321–1350
ISEF · 2025
Microbiology
Aliivibrio fischeri is a single-celled, gram-negative, rod-shaped bacterium that lives within the ocean. When in healthy waters, its cell membrane quorum senses with other bacterium near it…
ISEF · 2025
Biomedical and Health Sciences
The use of GLP-1 agonists, including Ozempic and Exenatide, has increased by almost 40-fold between 2017 and 2021. These drugs are widely used to regulate glucose metabolism in type 2 diabet…
ISEF · 2025
Biomedical and Health Sciences
Cognitive decline poses a significant public health challenge among aging populations. Green tea contains epigallocatechin gallate (EGCG), a catechin widely hypothesized to protect against n…
ISEF · 2025
Biomedical and Health Sciences
Today, up to 3.6 million Americans suffer from Inflammatory Bowel Disease (IBD) —a group of debilitating conditions, including Crohn’s disease and ulcerative colitis, that cause chronic infl…
ISEF · 2025
Embedded Systems
This project aimed to address problems inherent in fin-controlled rocketry systems. Common problems include cost, complexity, and size, and this project solved them by creating a simple, low…
ISEF · 2025
Technology Enhances the Arts
Nearly 5% of the global population, or 430M people, require hearing loss rehabilitation, while in the U.S., about 11M people experience serious hearing difficulties. Many deaf individuals co…
ISEF · 2025
Microbiology
The World Health Organization reports Vibrio cholerae serogroup O139 as a high-priority pathogen that has the potential to precipitate the 8th cholera pandemic. This project explores the use…
ISEF · 2025
Energy: Sustainable Materials and Design
Despite 70% of our planet being covered by water, only 3% of that is fresh water, with the vast majority being saline. World WildLife predicts that two-thirds of the world’s population may f…
ISEF · 2025
Biomedical Engineering
The tumor suppressor protein p53, is mutated in 50% of human cancers. DNA damage activates kinases which stabilize p53 through phosphorylation and paradoxically can promote cancer cell survi…
ISEF · 2025
Cellular and Molecular Biology
Although CAR T-cell therapy has significantly improved treatment outcomes for hematologic B-cell malignancies, challenges such as relapse and mortality rates (35-50% within 6-12 months post-…
ISEF · 2025
Behavioral and Social Sciences
As of 2022, 49% of U.S. adolescents and 25% of adults have psychological disorders, with 60% also experiencing gastrointestinal disorders. The aim of the current study is to determine whethe…
ISEF · 2025
Robotics and Intelligent Machines
Heart disease is a broad term that encompasses various heart conditions. It is also the leading cause of death both in the United States and globally. This disease claims millions of lives e…
ISEF · 2025
Engineering Technology: Statics & Dynamics
The Shell and Tube Heat Exchanger is widely used in high-pressure industrial applications such as petrochemical processing and offshore oil rigs. This study examines the thermal performance…
ISEF · 2025
Environmental Engineering
As global warming and climate change intensify, our planet continues to deteriorate. One of the most well-known ways of combating this problem is renewable energy sources. In many cases, ren…
ISEF · 2025
Materials Science
The purpose of this project was to design polyimide-taped high entropy alloys (HEAs) to shield ionizing radiation. It was hypothesized that if the thickness of each HEA is increased, then th…
ISEF · 2025
Chemistry
As the climate crisis demands cleaner and more efficient energy systems, hierarchically self-assembled nanostructures are emerging as promising tools for sustainable technologies. Hierarchic…
ISEF · 2025
Physics and Astronomy
Supermassive black hole accretion disks, predicted to emit optical continuum from regions spanning light-hours, remain challenging to resolve via traditional reverberation mapping (RM) techn…
ISEF · 2025
Engineering Technology: Statics & Dynamics
Compared to common open-loop stepper motors, 3-Phase synchronous motors can deliver superior responsiveness, repeatability, and speed with minimal noise, wear, and heat. Brushless DC (BLDC)…
ISEF · 2025
Systems Software
Heart murmurs are abnormal sound signals generated by turbulent blood flow and are closely associated with specific structural heart disorders. Current murmur analysis methods only look towa…
ISEF · 2025
Biomedical Engineering
Three-hundred and eighty three children have died in school shootings since the devastating Columbine high school tragedy. Exsanguinating hemorrhage is the main cause of death from gunshot w…
ISEF · 2025
Engineering Technology: Statics & Dynamics
Global warming is a significant environmental threat, and vehicles contribute to it greatly. This project not only aims to design a power supply that does not contribute to global warming bu…
ISEF · 2025
Animal Sciences
Microplastics are widespread pollutants that pose risks to human health. Caenorhabditis elegans, a small nematode with a simple nervous system, is commonly used in biological research to ass…
ISEF · 2025
Microbiology
For my Science fair project, I investigated the cleanliness of public restrooms, specifically finding which area was the grossest. My hypothesis was that door handles would be the dirtiest s…
ISEF · 2025
Biomedical Engineering
This project tested which prosthetic materials are habitable for human epithelial cells, primarily to determine if a prosthetic could integrate with the body. Three mesh materials (stainless…
ISEF · 2025
Systems Software
With extreme heat events becoming more frequent and severe due to climate change, accurate temperature prediction is critical for preparedness and risk mitigation. Traditional offline models…
ISEF · 2025
Environmental Engineering
Resulting from climate change and aggressive farming practices, desertification is a major threat to the environment and survival of millions, as according to the United Nations, desertifica…
ISEF · 2025
Materials Science
Purpose: To conserve water in space, scientists have come up with an efficient way to recycle it. While studying this, I wondered how the water would be conserved once we find a planet fit f…
ISEF · 2025
Technology Enhances the Arts
In the last decade, there have been monumental breakthroughs regarding the use of artificial intelligence in "human" fields, such as language and art. Coinciding with these developments, the…
ISEF · 2025
Computational Biology and Bioinformatics
MicroRNAs (miRNAs) are non-coding RNAs that bind to the coding sequences of target messenger RNAs (mRNAs), where they regulate gene expression. Mutations of miRNA binding sites within risk g…
ISEF · 2025
Cellular and Molecular Biology
Epigenetics is the study of how environmental stimuli affect gene expression without altering the DNA sequence. DNA methylation is an epigenetic mechanism in which a 5-methyl group binds to…