Biochemistry
Contemporary studies have shown that alpha-synuclein oligomers may have a pivotal role in the pathogenesis of Parkinson's Disease (PD) by inducing cellular toxicity leading to dopaminergic n…
Behavioral and Social Sciences
Attention-deficit/hyperactivity disorder (ADHD) is routinely treated with pharmacological agents such as atomoxetine, yet the downstream effects of these medications on gut microbiome remain…
Chemistry
This study evaluates the feasibility of MnO2 as a transparent, cost-effective alternative to TiO2, the industry standard, in photocatalytic remediation and degradation of PET microplastics.…
Animal Sciences
Hydra are aquatic invertebrates with decentralized nervous systems, meaning their neurons are completely dispersed throughout their bodies. These organisms possess the most basal nervous sys…
Behavioral and Social Sciences
Racial disparities in federal sentencing have long raised concerns about fairness and the effectiveness of policies intended to mitigate them. This study examines whether judicial adherence…
Biomedical Engineering
Advanced prosthetic technologies have improved mobility for individuals with limb loss, yet restoring natural motor control and sensory perception remains a crucial challenge. Current system…
Earth and Environmental Sciences
The South Pacific Convergence Zone (SPCZ) is the largest band of precipitation in the Southern Hemisphere stretching from the Western Pacific Warm Pool (WPWP) to French Polynesia. The WPWP c…
Behavioral and Social Sciences
Mental health disorders affect approximately 23% of American adults, highlighting the need for improved diagnostic tools (NIMH, 2024). Current diagnoses rely on self-reported surveys and cli…
Software Design
As hyper-realistic deepfakes grow into one of the world’s most pressing crises, the rush to secure digital integrity has made watermarking one of the most urgently researched sectors in cybe…
Biochemistry
Oligonucleotides, especially siRNAs, have been identified as a point of interest in recent research due to their capability for targeting of “undruggable” targets. siRNAs bind to and guide t…
Biomedical Engineering
Gut motility disorders affect over 20% of the population, but standard diagnostic tools, including endoscopy and manometry, are invasive, expensive, limited to clinical settings, and don’t t…
Earth and Environmental Sciences
Nine of NOAA’s top 10 costliest natural disasters were major hurricanes, highlighting the logically clear need to protect the 40% of the global population living near coastal areas. Despite…
Energy: Sustainable Materials and Design
Thermoelectric generators (TEGs) remain limited to roughly 6–8% efficiency due to material constraints, but their solid-state design enables exceptional reliability. Thermophotovoltaic (TPV)…
Cellular and Molecular Biology
Cancer and autoimmune diseases present an immunological paradox: T cells adopt opposing functional states. In cancer, T cells become dysfunctional and lose effector function, failing to elim…
Cellular and Molecular Biology
RET (Rearranged During Transfection) is a receptor tyrosine kinase (RTK) that is frequently altered across multiple cancer types. One such alteration is KIF5B-RET, a fusion oncogene that dri…
Behavioral and Social Sciences
In recent years, it is estimated that rates of stress, anxiety, and depression have increased by 25%. The increased prevalence of these conditions has been paralleled by an estimated 8% decl…
Microbiology
Filamentous fungi offer promising solutions for upcycling industrial food byproducts. Neurospora intermedia, used for centuries in Western Java to ferment red oncom from a byproduct of soy m…
Cellular and Molecular Biology
Cancer genomic alterations often create unique vulnerabilities that can be exploited for precise treatment. Inhibitors exploiting synthetic lethal relationships have recently shown clinical…
Earth and Environmental Sciences
It's been hypothesized that carbonaceous chondrite meteorites can transport compounds crucial to planetary habitability. Meteorites generate hydrothermal systems through impact energy dissip…
Microbiology
CRISPR–Cas systems enable bacteria to defend against viral infection through RNA-guided nucleases and accessory proteins, though the functions of many accessory components remain unclear. Th…
Translational Medical Science
Diagnosing drug-resistant strains Mycobacterium tuberculosis (Mtb) is critical for informing treatment plans and limiting infections. However, existing diagnostics are slow and cover a narro…
Biomedical and Health Sciences
Food allergy (FA) affects 18% of the population and is driven by type-2 inflammation, epithelial barrier dysfunction, and tight junction (TJ) disruption. Recent studies identify Zonulin and…
Biomedical and Health Sciences
Music reduces stress and improves health by affecting the autonomic nervous system, and transcriptomic studies show it increases alpha-synuclein (SNCA), which regulates neuronal activity. Al…
Robotics and Intelligent Machines
Globally, tens of millions of people suffer from lower body impairments, including spinal cord injuries, cerebral palsy, stroke, and muscular dystrophies, leading to loss of independent mobi…
Engineering Technology: Statics & Dynamics
Improving structural efficiency in aircraft wings is a critical objective in aerospace engineering, particularly as the industry moves toward more sustainable and lightweight designs. Wing r…
Mathematics
Urban accessibility optimization is a pressing challenge for sustainable urban development. Classical graph-theoretical methods, such as the Steiner tree problem, provide a framework for con…
Physics and Astronomy
Reconciling general relativity and quantum field theory remains a central challenge in physics. Hawking radiation, a quantum effect where black holes emit radiation, provides a natural testi…
Biomedical and Health Sciences
Carotenoids are lipid-soluble dietary pigments and vitamin A precursors that regulate gene transcription via RARA and RXRA nuclear receptors. Retinoid signaling controls differentiation, pro…
Materials Science
Reducing carbon emissions in modern engineering has a critical tradeoff: materials must be lightweight to improve energy efficiency, yet strong enough to maintain structural integrity. Polye…
Translational Medical Science
Peritoneal dialysis, one type of dialysis for patients with end-stage renal disease, can be complicated by peritonitis, a life-threatening inflammation of the peritoneum typically caused by…