189 projects whose affiliated fair was here, most recently in 2026.
ISEF records a state or province for some finalists and not others, so these counts do not add up to the country total.
189 projects · showing 1–30
ISEF · 2026
Computational Biology and Bioinformatics
Nearly 50% of human IVF embryos arrest before reaching the blastocyst stage, yet the molecular mechanisms causing this failure remain poorly understood. Current literature examines omics in…
ISEF · 2026
Embedded Systems
Motorcycle riders face high risks due to limited visibility and awareness, which can lead to collisions. The ARC Helmet (Automated Rider Companion) improves rider safety by providing real-ti…
ISEF · 2026
Embedded Systems
Flashing lights are a common everyday occurrence that may seem insignificant but for people who suffer from migraines, neurodivergence with light sensitivity or photosensitive seizures, cert…
ISEF · 2026
Robotics and Intelligent Machines
By 2052, one quarter of the population will be over the age of 65, with adults over 85 the fastest growing segment. Supporting older adults to maintain their independence is a global priorit…
ISEF · 2026
Translational Medical Science
Creutzfeldt-Jakob Disease (CJD) is a deadly neurodegenerative disease caused by prion proteins (PrPSC), which trigger normal cellular proteins to misfold, resulting in aggregation and neuron…
ISEF · 2026
Computational Biology and Bioinformatics
Toxoplasma gondii infects up to one-third of the global human population. In its dormant state, this parasite can persist in its host for life. No treatments exist for this chronic stage of…
ISEF · 2026
Microbiology
Fungal pathogens pose an enormous threat to global health, and a growing number of pathogens are developing resistance to our already limited arsenal of antifungals. Overexpression of efflux…
ISEF · 2026
Computational Biology and Bioinformatics
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of 12%, driven in part by unresolved mechanisms of therapeutic resistance. While single-cell RNA sequencing has advanced…
ISEF · 2026
Biomedical and Health Sciences
T-cell malignancies are aggressive hematologic cancers with limited targeted treatment options and high relapse rates. These malignancies are characterized by the overexpression of the PD-1…
ISEF · 2026
Environmental Engineering
Marine ecosystems are paramount to the planet's health, but they are threatened by human-introduced pollutants. In particular, microplastics have proven to be detrimental to aquatic wildlife…
ISEF · 2026
Translational Medical Science
Schizophrenia is a chronic neurodevelopmental disorder affecting approximately 24 million people worldwide. Despite its severity, its biological mechanisms remain poorly understood, and curr…
ISEF · 2026
Physics and Astronomy
This project develops a first principles framework linking molecular-scale randomness to macroscopic fluid behavior through coarse-grained velocity fields. Modeling molecular collisions as a…
ISEF · 2026
Physics and Astronomy
Quantum computers encode information in qubits, which are susceptible to physical noise. To protect information, quantum systems use error correction codes like the surface code, detecting e…
ISEF · 2026
Environmental Engineering
Non-Polar Organic Contaminants (NPOCs) such as Micro/Nano-sized Microplastics (MNMPs), oils and Benzene, Toluene, Ethyl Benzene, Xylene (BTEX) are emerging contaminants that are critical thr…
ISEF · 2026
Software Design
Phishing, credential theft, and password reuse still remains as a major causes of digital account compromise. This project investigated if a low-cost hardware-bound identity device could pot…
ISEF · 2026
Earth and Environmental Sciences
Sensing of the Tropopause and Marine Boundary Layer (MBL) is limited by cost and operational constraints of conventional fixed monitoring systems. WindDrift is a dual-modality Lagrangian sen…
ISEF · 2025
Biomedical Engineering
Over 1.5 billion people worldwide experience hearing loss, and 2.2 billion have vision impairments. Both require assistive technologies; however, millions lack access due to cost. To address…
ISEF · 2025
Environmental Engineering
Only half of global wastewater is treated—dropping to just 4.3% in low-income countries—while treatment consumes 4% of global electricity. With the energy sector already accounting for 75% o…
ISEF · 2025
Engineering Technology: Statics & Dynamics
Jetstream is the world’s fastest drone, flying at 40% of the speed of sound. Jetstream paves the way for future high-speed-drone design, enabling future drones to tackle a new realm of high-…
ISEF · 2025
Physics and Astronomy
Traditional exoplanet detection methods often overlook multi-planet systems containing long-period or non-transiting planets due to observational biases favoring short-period transiting plan…
ISEF · 2025
Earth and Environmental Sciences
The widespread use of synthetic surfactants in household detergents pose major environmental risks due to chemical persistence of non-biodegradable petrochemicals in ecosystems. However, Sap…
ISEF · 2025
Computational Biology and Bioinformatics
Traditional Darwinian models of evolution treat adaptive selection as the primary evolutionary factor for most traits. Although this approach is predictive in many cases, it struggles to exp…
ISEF · 2025
Embedded Systems
Hospital-induced Delirium (HID) affects 30% of patients causing fluctuating cognitive disturbances, tripling mortality risk and costing North American healthcare systems $164 billion annuall…
ISEF · 2024
Materials Science
Stem cell therapy holds tremendous promise for treating illnesses by regenerating damaged body tissues. However, no stem cell treatments for cardiovascular, pulmonary, neurological, or ortho…
ISEF · 2024
Embedded Systems
The high cost of traditional microscopes presents a barrier to accessibility for critical pursuits such as drug development, cancer research, and clinical diagnostics, rendering them inacces…
ISEF · 2024
Engineering Technology: Statics & Dynamics
I have been sailing for the past 2 years. Most sailboats these days run on diesel engines, while the fuel used for them is generally more sustainable than standard diesel, I wanted to find o…
ISEF · 2024
Engineering Technology: Statics & Dynamics
As robotics and computer software advance, robotics have the potential to replace hazardous tasks. Utilizing computer hardware and software, we designed and engineered a tracked robot platfo…
ISEF · 2024
Biomedical and Health Sciences Fourth Award
Systemic lupus erythematosus (SLE) is an incurable chronic autoimmune disease in which the immune system attacks its tissues, causing widespread inflammation and organ damage. Due to the lac…
ISEF · 2024
Engineering Technology: Statics & Dynamics Second Award
The 2023 Canadian wildfire season, marked by a quintupling of damage relative to the past decade’s average and the tragic loss of four firefighters, underscores the urgent need for advanceme…
ISEF · 2024
Translational Medical Science
Malaria is a deadly disease that claims the lives of over 460,000 children annually. Current diagnostic methods use labor-intensive microscopy to image Giemsa-stained blood smears, limiting…