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The Repurposing of Prednisolone: Inhibition on the Formation of Pancreatic Cancer Associated Fibroblasts (CAFs) Through Ets1-HMGXB3 Axis

Biomedical and Health Sciences

Pancreatic cancer is one of the deadliest diseases in the world. Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment (TME) and important immune-nega…

The RIGHT Model: A Novel Personal Development Tool for Adolescents

Behavioral and Social Sciences

Deficit in learning and social skills during the COVID-19 pandemic causes a decrease in personal development (PD) among adolescents. Thus, we developed The RIGHT Model based on Cognitive Beh…

Thermally Triggered Motion of Pyrolytic Graphite on a Magnet Array

Physics and Astronomy

When hydrocarbon is heated to its decomposition temperature pyrolytic graphite can be crystalized in ordered layers. This material has an unusual characteristic. It can levitate above a cheq…

The Role of Cell-to-Cell Transmission in HIV Infection: Insights From a Mathematical Modeling Approach, Year 2

Computational Biology and Bioinformatics

HIV infection remains a global public health challenge. While current drug treatments effectively suppress HIV viral loads below the detection level, complete eradication of the virus remain…

The Role of DNA Methylation in the Inflammatory Response Following the Consumption of Glutamate in a Patient With Psoriatic Arthritis: A Case Study in Personalized Medicine

Translational Medical Science

The usage of DNA methylation at CpG sites within the gene body has the potential to be used as an alternative to promoter methylation for identifying gene expression. In this study, we focus…

The Role of Neuronal Primary Cilia in Alzheimer’s Disease

Cellular and Molecular Biology

Alzheimer’s disease (AD) is the leading cause of dementia, accounting for 60-80% of cases in the United States. Failed interventions, aimed at the symptoms of the disease, have created a dri…

The Role of TALE Homeodomain Proteins in the Haploid to Diploid Transition of the Fern Ceratopteris richardii

Plant Sciences Third Award

TALE homeodomains (TALE-HD) are a large class of genes encoding proteins that act as transcription factors in eukaryotes to regulate major developmental and life cycle changes. Their ancestr…

The Secrets of Healthy Aging: Semi-Automated Discovery of Natural Senolytics

Translational Medical Science Fourth Award

As populations around the world grow older and pandemics ravage global health, the burdens of age-related diseases, such as arthritis, heart disease, and cancer, are increasingly prevalent.…

The Spectral Signature of the Coherent Electronic Excitation of Ethylene

CREOL, University of Central Florida Electronic motion governs all chemical transformations. For example, when a short light pulse excites a molecule, it creates a charge fluctuation that mi…

The Synergistic Effect of Omega-3 Fatty Acids (DHA and EPA) and Zinc Picolinate on Traumatic Brain Injury in Galleria mellonella

Biomedical and Health Sciences Third Award

Every 15 seconds, a person suffers a traumatic brain injury (TBI), a leading cause of mortality and lifelong disability worldwide. Despite its prevalence, effective therapeutic treatments ta…

The Therapeutic Potential of Suppressing Chemokine Receptor CXCR4 Pathway Components in Small Cell Lung Cancer (SCLC) Through First-Generation Potent Inhibitors

Translational Medical Science

Characterized as recalcitrant cancer, small cell lung cancer (SCLC) is a rare neuroendocrine-type lung cancer with growing resistance to immune checkpoint inhibitors, leading to rapid metast…

The Ultimate Plant-Powered Bike Lube

Chemistry

The project aims to explore the use of plant corrosion inhibitors compared to toxic bike chain lubricants on carbon steel bike chains. Current bike maintenance companies use petroleum and to…

The Use of Lichen-derived Secondary Metabolites as Pesticides

Animal Sciences

Bean beetles are an agricultural pest, destroying crops of legumes like mung beans and cowpeas. They decrease the yields of infested crops by up to 90% and reproduce quickly in warmer temper…

The Use of Reduced Graphene Oxide in Fluorinated Phthalocyanines and Their Applications in Gas Sensing

Chemistry

Gas sensing is vital for human health, industrial safety, and adherence to air quality standards (Tonezzer & Van Duy, 2023). Metal phthalocyanines (MPc’s) are promising gas sensing candidate…

The Use of Rhythmic Light Therapy to Entrain Gamma Oscillations and the Circadian System in Patients with Alzheimer's Disease and Related Dementias (ADRD)

The increasing prevalence of dementia, particularly Alzheimer's disease (AD), has prompted an urgent exploration of interventions for patients, particularly those with Mild Cognitive Impairm…

The Use of Rhythmic Light Therapy To Entrain Gamma Oscillations and the Circadian System in Patients With Alzheimer's Disease and Related Dementias (ADRD)

Behavioral and Social Sciences Fourth Award

The increasing prevalence of dementia, particularly Alzheimer's disease (AD), has prompted urgent exploration of interventions for patients, particularly those with Mild Cognitive Impairment…

The Utilization of Labeo catla Fish Scales for the Effective Defluorination of Water With Excessive Fluoride Concentrations to Refine Water in Developing Countries

Earth and Environmental Sciences

In Bangladesh, the concentration of fluoride in the water is typically high. High levels of fluoride can lead to severe health issues in the future, such as bone damage. However, Labeo Catla…

The Virtual Cardiologist: Three Deep Learning Pipelines in an Inexpensive Portable Device and Web/Mobile Application for Rapid Cardiovascular Diagnosis and Clinical Decision-Making

Robotics and Intelligent Machines Fourth Award

Background: Heart disease is the foremost cause of death worldwide, and specialty care such as cardiologists and expensive Doppler echocardiograms are scarce in rural areas. There is signifi…

They Don’t Know When to Quit: Investigating “Overharvesting” in a Simulated Berry -Picking Experiment

Harvard Medical School From assessing mammograms to finding lost keys, visual searches are ubiquitous. This study employs a berry-picking scenario to study the effect of external distraction…

Tinted Truths: Revealing the Relationship Between Tartrazine and the Dysregulation of Retrotransposons and p53 Expression in Drosophila melanogaster

Cellular and Molecular Biology Fourth Award

The p53 gene is a tumor suppressor in the human body that is mutated in 50-60% of human cancers. p53 acts to suppress retrotransposons (jumping genes) within the genome which are prevalent i…

TNBCnano: Novel Layer-By-Layer Nanoparticles for Systemic Combination Delivery of MRP1 siRNA and Doxorubicin for Triple-Negative Breast Cancer Treatment

Materials Science

Every minute, four women are diagnosed with Triple Negative Breast Cancer (TNBC). Yet, TNBC remains the only subtype of breast cancer without an approved biological treatment, with an averag…

To Identify a Multi-Gene Biomarker Based on Most Frequently Occurring Genetic Mutations Across Cancers Through Bioinformatics and Verify Its Efficacy to Detect a Wide Range of Cancers Using Statistical Analysis

Translational Medical Science

Most cancer biomarkers are specific to a cancer type(s). By focusing on the most frequently occurring gene mutations across different types of cancers, a multi-gene biomarker was identified…

To Infinity Egg Beyond: Novel Systems for Hyper-Customizable Egg Models

Biomedical Engineering Third Award

The Framework for Embryonic Analysis Through Hyper-customization Enhancement Research (FEATHER) enhances avian egg studies, enabling custom egg modification while preserving embryo viability…

TonoSense: A Novel IOP Monitoring Device for At-Home Glaucoma Screening

Biomedical Engineering

Glaucoma, the second leading cause of blindness, affects more than 80 million people worldwide. This disease is asymptomatic, so the patient is unaware until vision impact has started. A sig…

To Precess or to Retrogress: Dynamics and Anomalous Sway Precession of Euler's Magnetic Pendulum

Physics and Astronomy

The Euler’s Magnetic Pendulum system consists of a uniform cylindrical rod suspended within a magnetic potential field beneath a horizontal plane. Typically, when a relevant pendulum motion…

Toroidal Propellers: A Novel Approach to a Quieter Future for Two-Bladed Aircraft

Engineering Technology: Statics & Dynamics

Exploring toroidal propellers for two-bladed aircraft revealed significant challenges in the design process, notably the absence of a comprehensive mathematical model and insufficient constr…

Toward Realization of Novel Quantum Materials via Magneto-Synthesis

Physics and Astronomy

It has been widely recognized that whoever controls the development of novel materials controls technologies that evolve from them. The science and technology of materials synthesis are at t…

Towards a Closed Carbon Cycle: Novel Organic Microparticles & Encapsulants for Carbon Dioxide Capture & Conversion to Value Added Products

Materials Science

Carbon dioxide (CO2) emissions have devastating impacts on agriculture, human life, and the environment. This research developed the first-ever cost-effective, environmentally sustainable ma…

Towards Improved Recognition and Diagnosis of Autism Among Females – A Novel Approach Using Machine Learning

Behavioral and Social Sciences Fourth Award

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social and verbal impairments, affecting 1 in 36 children. ASD diagnosis is based on behavioral observations…

Toxin-Like Microproteins: A Novel Approach to Unveil the Intricacies of Acetylcholine Receptors

Biochemistry

Over 50 million people are diagnosed with neurodegenerative diseases worldwide, however the fundamental molecular mechanisms for the development of these diseases are not well-researched. Un…