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CFD Simulations Prevent Brain Aneurysms

Biomedical Engineering

Many intracranial aneurysms can be treated using flow diversion, in which a finely meshed stent is used to reduce blood flow into an aneurysm. Over time, this leads to endothelial tissue reg…

C-Fos and Reelin Protein Localization: Brain Fluorescence Imaging of Activity Pathways in Mice During Sensory Behavior Tasks?

Animal Sciences Fourth Award

Organisms detect sensory stimuli through peripheral neurons and transmit the information to cortical brain regions for processing: creating an internal neural map of the external environment…

Characterization and Therapeutic Application of the ICOS Receptor To Treat Peripheral T-Cell Lymphoma

Cellular and Molecular Biology Third Award

Peripheral T-cell lymphoma (PTCL) is a rare and aggressive non-Hodgkin lymphoma resulting from clonal proliferation of mature post-thymic T-cells. The mechanisms behind PTCL development and…

Characterization of Antimicrobials From the Soil Bacterium Xenorhabdus szentirmaii

Biochemistry Fourth Award

Antimicrobial resistance(AMR) is a global health threat and the discovery of new antimicrobial compounds has been limited in the past four decades. New antimicrobials with new functions are…

Characterization of Pd-L1 in a Barrett's Esophageal Adenocarcinoma Cell Culture Model

Biomedical and Health Sciences

Introduction While the incidence of esophageal adenocarcinoma is rapidly increasing, the prognosis remains poor with a five-year survival rate of 20%. Therefore, the discovery of new molecul…

Characterizing a Novel Flare in the Distant Quasar VIIIZw233

Physics and Astronomy Second Award

Every second in the universe an exciting event is occurring, whether it be the collision of two black holes or the death of a star in an explosive supernova. One such event is a Tidal Disrup…

Characterizing a Novel Flare in the Distant Quasar VIIIZw233

The universe is filled with turbulent events, from the collision of black holes to the death of a star in an explosive supernova. One such event is a Tidal Disruption Event (TDE), where a st…

Chemical Analyses of Archeological Pottery Sherds Found Along the Colorado River, Grand Canyon, Arizona

Chemistry

My Zuni ancestors lived in the Grand Canyon long ago. A Zuni medicine man pointed out many Zuni features to my mentor on a Grand Canyon Rafting Tour, sponsored by the Grand Canyon Conservanc…

Chemical Modification of Acetaminophen to Decrease Liver Toxicity

Chemistry Third Award

Each week, over 60 million individuals consume acetaminophen in the U.S. alone. Despite global reliance for its analgesic & antipyretic (pain & fever relief) properties in medications, aceta…

Chlorine-Emulsified PDMS for Water Droplet Based Energy Harvesting

Energy: Sustainable Materials and Design

The use of smart devices in applications like wildlife tracking and blue energy has become widespread, relying on batteries to power devices in remote locations. However, the frequent mainte…

Chlorophyll and Accessory Pigments in Dye-Sensitized Solar Cells

Energy: Sustainable Materials and Design

The average solar panel is able to convert around 15-20% of solar energy into chemical energy. Therefore, there is a mass amount of energy that has the capability to be captured and harnesse…

Chromoplexy Rearrangements: Investigating the Functional and Diagnostic Role of Novel Mutational Mechanisms Uncovered In Cancer Genomes

Computational Biology and Bioinformatics Second Award

Conventionally, tumorigenesis is understood as a gradual accumulation of genetic mutations. Yet, chromoplexy rearrangements (ChRs) are a mutational phenomenon characterized by highly complex…

Chronic Developmental Manganese Exposure Affects Behavioral Phenotypes in Dopamine Transporter Mutant Mice

Behavioral and Social Sciences

Overexposure to manganese (Mn) through contaminated water or occupational environment has been shown to result in dopaminergic dysfunction and overall neurotoxicity in the human brain [1]. T…

Chronic Sleep Deprivation Activates NLRP3 Inflammasome and Exacerbates Aβ Plaques Deposition in a Mouse Model of Alzheimer’s Disease

Chronic sleep deprivation (CSD) is a condition resulting from insufficient sleep over a prolonged period of time, which affects one in three adults in the United States. Alzheimer’s disease…

Ciliatine-Induced Apoptosis in Colorectal Cancer Cells: Targeting PPARδ for Tumor Suppression

Colorectal cancer (CRC) is a leading cause of cancer-related deaths, and gut bacteria play a crucial role in its pathogenesis. Gut bacteria metabolize dietary substrates to produce various m…

Circulating Chymase and Chronic Kidney Disease: A Multivariable Analysis of Current Treatments, Demographics, and Clinical Risk Factors

Biomedical and Health Sciences

Chronic kidney disease (CKD) results in a progressive loss of kidney function over time, affecting 37 million in the US. Chymase is the primary enzyme mediating angiotensin II formation inde…

Circulating Chymase and Chronic Kidney Disease: An Analysis of Current Treatments, Demographics, and Clinical Risk Factors

Chronic kidney disease (CKD) results in a progressive loss of kidney function over time, affecting 37 million in the US. Chymase is the primary enzyme mediating angiotensin II formation inde…

CisRF: A Novel Machine Learning Approach to Predict Context Dependent Impacts of Disease Associated Regulatory Elements on Gene Expression

Genome Wide Association Studies have identified 560,000+ Single Nucleotide Polymorphisms (SNPs) associated with disease, most of which are not in protein -coding regions of the genome. Howev…

Classical and Modern Control Theory for Rotor Sail Active Seakeeping

90% of goods move by cargo ships, contributing to 3% of climate change emissions, 7.6 million childhood asthma cases, and 150,000 premature deaths annually. There is a need for climate chang…

CLDN5 Downregulation and Albumin: Investigating Hallmarks of Blood-Brain Barrier Breakdown as Novel Biomarkers of Suicide Neuropathology

Biomedical and Health Sciences

Over 1 million deaths annually can be attributed to suicide, yet no biomarkers exist. This study investigated blood-brain barrier (BBB) disruption by examining claudin-5 (CLDN5) epigenetic a…

Clean Water: Analysis of Interfacial Tension Anionic Surfactant Effects on Evaporative Rate, Molecular Similarity Analysis, and Oil Spill Modeling

Earth and Environmental Sciences

Increasing pollution in large water bodies poses a significant threat to the availability of safe drinking water. As pollutants (surfactants) decrease interfacial tension, when a contaminant…

Clear: Utilizing Glasses-Based Beamformers to Improve Speech Clarity and Spatial Context for the Hearing Impaired

Biomedical Engineering Third Award

Hearing loss is the fourth most prevalent disability worldwide, affecting one in five people, and is correlated with depression, isolation, and decreased life expectancy. Innovation in heari…

CNS-Permeable Glutamate Carboxypeptidase-II (GCPII) Inhibitors as Potential Therapeutics in the Treatment of Traumatic Brain Injury (TBI)

Translational Medical Science

Traumatic Brain Injury (TBI) is an intracranial damage common among soldiers and impact-sport athletes. In severe cases, TBI is associated with neurodegeneration and dementia if left untreat…

Cocoa’s Cognitive Triumph: The Rescue of the Alzheimer’s Model of Drosophila melanogaster With Theobroma cacao Supplementation

Animal Sciences Third Award

Alzheimer's disease, the most prevalent form of dementia affecting over 24 million people worldwide, is characterized by cognitive decline and progressive neurodegeneration; this is mainly d…

COCOTherm: A Simulated Thermal Dataset for Training Wildlife Monitoring Models With Optical to Thermal Image Conversion

Systems Software

COCOTherm addresses the challenges of monitoring wildlife overpasses as part of the I-90 Snoqualmie Pass East Project. The wildlife monitoring program for this project involves 15 networked…

Coding an Algorithmic Day Trading Strategy - Power of 3

Systems Software

Coded stock trading strategies are a fast-growing interest as they can help businesses and individuals not only learn but also make more money while putting themselves at less risk. I decide…

Collision-Free Commutes: Designing a Blind Spot Detection System for Cyclists Using an Ultrasonic Sensor and Computer Vision

Robotics and Intelligent Machines

Riding a bike is a carbon-efficient mode of transportation and a positive way to maintain fitness. However, the inherent difference in speed and size between cars and bikes makes it dangerou…

Colorimetric Smart Packaging System: A Carbohydrate-Based Plastic Alternative for Detecting Food Spoilage

Materials Science

Food safety is one of the most important components of human life. The World Health Organization estimates that foodborne contamination kills 420,000 people per year worldwide. To combat thi…

Combating Huanglongbing Through the Development of a Non-phytotoxic Oxytetracycline Formulation and Novel Fluorescence-Based Detection System

Plant Sciences Fourth Award

Huanglongbing (HLB), more commonly known as citrus greening, is a devastating disease caused by bacteria that colonize tree phloem, restrict nutrient flow, and cause symptoms such as fruit d…

Combating Superbugs: Using Natural Compounds as Down-Regulators of Biofilms Formation in ESKAPE Pathogens (An in silico Study)

Microbiology

Biofilm is the consortia of sessile groups of microbial colonies that adhere on biotic and abiotic surfaces with the help of extracellular polymeric substances (EPS) and glycocalyx. ESKAPE b…